| Full name: FA complementation group G | Alias Symbol: FAG | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 2189 | HGNC ID: HGNC:3588 | Ensembl Gene: ENSG00000221829 | OMIM ID: 602956 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FANCG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FANCG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FANCG | 2189 | 203564_at | 0.6967 | 0.0559 | |
| GSE20347 | FANCG | 2189 | 203564_at | 0.5318 | 0.0043 | |
| GSE23400 | FANCG | 2189 | 203564_at | 0.6726 | 0.0000 | |
| GSE26886 | FANCG | 2189 | 203564_at | 0.6592 | 0.0150 | |
| GSE29001 | FANCG | 2189 | 203564_at | 0.7378 | 0.0024 | |
| GSE38129 | FANCG | 2189 | 203564_at | 0.7488 | 0.0000 | |
| GSE45670 | FANCG | 2189 | 203564_at | 0.5979 | 0.0017 | |
| GSE53622 | FANCG | 2189 | 96258 | 0.7733 | 0.0000 | |
| GSE53624 | FANCG | 2189 | 96258 | 0.9747 | 0.0000 | |
| GSE63941 | FANCG | 2189 | 203564_at | 1.9813 | 0.0007 | |
| GSE77861 | FANCG | 2189 | 203564_at | 0.4160 | 0.2571 | |
| GSE97050 | FANCG | 2189 | A_23_P71644 | 0.6974 | 0.1496 | |
| SRP007169 | FANCG | 2189 | RNAseq | 0.7940 | 0.1007 | |
| SRP008496 | FANCG | 2189 | RNAseq | 1.0589 | 0.0041 | |
| SRP064894 | FANCG | 2189 | RNAseq | 1.0732 | 0.0000 | |
| SRP133303 | FANCG | 2189 | RNAseq | 0.5097 | 0.0028 | |
| SRP159526 | FANCG | 2189 | RNAseq | 0.3990 | 0.1324 | |
| SRP193095 | FANCG | 2189 | RNAseq | 0.3745 | 0.0029 | |
| SRP219564 | FANCG | 2189 | RNAseq | 1.2931 | 0.0055 | |
| TCGA | FANCG | 2189 | RNAseq | 0.4221 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by FANCG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FANCG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FANCG | 2189 | 3 | 13 | 14 | |
| GSE20123 | FANCG | 2189 | 3 | 13 | 14 | |
| GSE43470 | FANCG | 2189 | 3 | 10 | 30 | |
| GSE46452 | FANCG | 2189 | 6 | 15 | 38 | |
| GSE47630 | FANCG | 2189 | 1 | 20 | 19 | |
| GSE54993 | FANCG | 2189 | 6 | 0 | 64 | |
| GSE54994 | FANCG | 2189 | 6 | 12 | 35 | |
| GSE60625 | FANCG | 2189 | 0 | 0 | 11 | |
| GSE74703 | FANCG | 2189 | 2 | 7 | 27 | |
| GSE74704 | FANCG | 2189 | 0 | 11 | 9 | |
| TCGA | FANCG | 2189 | 16 | 44 | 36 |
Total number of gains: 46; Total number of losses: 145; Total Number of normals: 297.
Somatic mutations of FANCG:
Generating mutation plots.
Highly correlated genes for FANCG:
Showing top 20/919 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FANCG | ZWINT | 0.769387 | 10 | 0 | 10 |
| FANCG | BOP1 | 0.765435 | 3 | 0 | 3 |
| FANCG | BUB1B | 0.751167 | 9 | 0 | 8 |
| FANCG | SPC25 | 0.729274 | 11 | 0 | 11 |
| FANCG | MND1 | 0.727203 | 5 | 0 | 5 |
| FANCG | KIF18B | 0.725773 | 11 | 0 | 10 |
| FANCG | C19orf48 | 0.725639 | 3 | 0 | 3 |
| FANCG | KIF4A | 0.721506 | 12 | 0 | 11 |
| FANCG | MELK | 0.714717 | 12 | 0 | 10 |
| FANCG | MCM2 | 0.711664 | 11 | 0 | 10 |
| FANCG | MTFR2 | 0.709834 | 6 | 0 | 6 |
| FANCG | TIMELESS | 0.708694 | 11 | 0 | 9 |
| FANCG | CDC7 | 0.707805 | 11 | 0 | 11 |
| FANCG | MCM8 | 0.705639 | 6 | 0 | 6 |
| FANCG | GINS1 | 0.703177 | 11 | 0 | 10 |
| FANCG | E2F7 | 0.699825 | 7 | 0 | 7 |
| FANCG | GMNN | 0.699288 | 11 | 0 | 10 |
| FANCG | TRIP13 | 0.697862 | 11 | 0 | 11 |
| FANCG | MCM10 | 0.69681 | 10 | 0 | 9 |
| FANCG | PRKDC | 0.696305 | 7 | 0 | 7 |
For details and further investigation, click here
