| Full name: SUMO specific peptidase 6 | Alias Symbol: SUSP1|KIAA0797 | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 26054 | HGNC ID: HGNC:20944 | Ensembl Gene: ENSG00000112701 | OMIM ID: 605003 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SENP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SENP6 | 26054 | 202318_s_at | -0.1572 | 0.6806 | |
| GSE20347 | SENP6 | 26054 | 202318_s_at | 0.2064 | 0.1309 | |
| GSE23400 | SENP6 | 26054 | 202318_s_at | 0.2239 | 0.0072 | |
| GSE26886 | SENP6 | 26054 | 202318_s_at | 0.7405 | 0.0002 | |
| GSE29001 | SENP6 | 26054 | 202318_s_at | 0.2727 | 0.4789 | |
| GSE38129 | SENP6 | 26054 | 202318_s_at | 0.0816 | 0.4951 | |
| GSE45670 | SENP6 | 26054 | 202318_s_at | -0.1423 | 0.1853 | |
| GSE53622 | SENP6 | 26054 | 73051 | -0.7219 | 0.0000 | |
| GSE53624 | SENP6 | 26054 | 73051 | -0.5936 | 0.0002 | |
| GSE63941 | SENP6 | 26054 | 202318_s_at | -0.7161 | 0.0888 | |
| GSE77861 | SENP6 | 26054 | 202318_s_at | 0.3152 | 0.3592 | |
| GSE97050 | SENP6 | 26054 | A_33_P3376644 | -0.6585 | 0.0885 | |
| SRP007169 | SENP6 | 26054 | RNAseq | -0.1995 | 0.5091 | |
| SRP008496 | SENP6 | 26054 | RNAseq | 0.0430 | 0.8128 | |
| SRP064894 | SENP6 | 26054 | RNAseq | -0.1381 | 0.5432 | |
| SRP133303 | SENP6 | 26054 | RNAseq | -0.0154 | 0.8887 | |
| SRP159526 | SENP6 | 26054 | RNAseq | -0.1142 | 0.6087 | |
| SRP193095 | SENP6 | 26054 | RNAseq | -0.2064 | 0.0053 | |
| SRP219564 | SENP6 | 26054 | RNAseq | -0.1859 | 0.5044 | |
| TCGA | SENP6 | 26054 | RNAseq | -0.0796 | 0.0721 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SENP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SENP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SENP6 | 26054 | 1 | 3 | 26 | |
| GSE20123 | SENP6 | 26054 | 1 | 2 | 27 | |
| GSE43470 | SENP6 | 26054 | 3 | 0 | 40 | |
| GSE46452 | SENP6 | 26054 | 2 | 11 | 46 | |
| GSE47630 | SENP6 | 26054 | 8 | 4 | 28 | |
| GSE54993 | SENP6 | 26054 | 3 | 2 | 65 | |
| GSE54994 | SENP6 | 26054 | 8 | 6 | 39 | |
| GSE60625 | SENP6 | 26054 | 0 | 1 | 10 | |
| GSE74703 | SENP6 | 26054 | 3 | 0 | 33 | |
| GSE74704 | SENP6 | 26054 | 0 | 1 | 19 | |
| TCGA | SENP6 | 26054 | 9 | 20 | 67 |
Total number of gains: 38; Total number of losses: 50; Total Number of normals: 400.
Somatic mutations of SENP6:
Generating mutation plots.
Highly correlated genes for SENP6:
Showing top 20/675 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SENP6 | LIG3 | 0.813529 | 3 | 0 | 3 |
| SENP6 | SNAPC3 | 0.740728 | 3 | 0 | 3 |
| SENP6 | CCDC66 | 0.735375 | 6 | 0 | 6 |
| SENP6 | PPP1R15B | 0.730976 | 3 | 0 | 3 |
| SENP6 | NHS | 0.722989 | 4 | 0 | 4 |
| SENP6 | ARL5A | 0.715389 | 3 | 0 | 3 |
| SENP6 | EFHC1 | 0.713357 | 4 | 0 | 4 |
| SENP6 | SNX27 | 0.710919 | 3 | 0 | 3 |
| SENP6 | PITX2 | 0.710495 | 3 | 0 | 3 |
| SENP6 | KIAA0895 | 0.708611 | 3 | 0 | 3 |
| SENP6 | SARNP | 0.707805 | 3 | 0 | 3 |
| SENP6 | NAPEPLD | 0.707736 | 3 | 0 | 3 |
| SENP6 | TTC7B | 0.706116 | 3 | 0 | 3 |
| SENP6 | METTL9 | 0.705977 | 3 | 0 | 3 |
| SENP6 | FRA10AC1 | 0.703298 | 4 | 0 | 3 |
| SENP6 | TRIM38 | 0.702791 | 3 | 0 | 3 |
| SENP6 | RPS19BP1 | 0.701289 | 3 | 0 | 3 |
| SENP6 | NDRG3 | 0.700496 | 3 | 0 | 3 |
| SENP6 | ZCCHC7 | 0.698437 | 3 | 0 | 3 |
| SENP6 | LENG8 | 0.696625 | 3 | 0 | 3 |
For details and further investigation, click here
