| Full name: aryl hydrocarbon receptor nuclear translocator | Alias Symbol: HIF-1beta|bHLHe2 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 405 | HGNC ID: HGNC:700 | Ensembl Gene: ENSG00000143437 | OMIM ID: 126110 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ARNT involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05211 | Renal cell carcinoma |
Expression of ARNT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARNT | 405 | 218221_at | 0.1618 | 0.7008 | |
| GSE20347 | ARNT | 405 | 218222_x_at | -0.1825 | 0.0481 | |
| GSE23400 | ARNT | 405 | 218222_x_at | 0.0048 | 0.9184 | |
| GSE26886 | ARNT | 405 | 230619_at | 0.0601 | 0.8680 | |
| GSE29001 | ARNT | 405 | 218221_at | 0.1416 | 0.6112 | |
| GSE38129 | ARNT | 405 | 218221_at | 0.0081 | 0.9572 | |
| GSE45670 | ARNT | 405 | 218221_at | -0.0607 | 0.6572 | |
| GSE53622 | ARNT | 405 | 144082 | -0.2872 | 0.0000 | |
| GSE53624 | ARNT | 405 | 144082 | -0.1681 | 0.0013 | |
| GSE63941 | ARNT | 405 | 231016_s_at | 1.3341 | 0.0016 | |
| GSE77861 | ARNT | 405 | 218222_x_at | 0.0584 | 0.6994 | |
| GSE97050 | ARNT | 405 | A_24_P391568 | -0.0935 | 0.6463 | |
| SRP007169 | ARNT | 405 | RNAseq | -0.2643 | 0.4508 | |
| SRP008496 | ARNT | 405 | RNAseq | -0.0972 | 0.6913 | |
| SRP064894 | ARNT | 405 | RNAseq | -0.1354 | 0.3635 | |
| SRP133303 | ARNT | 405 | RNAseq | -0.1111 | 0.4204 | |
| SRP159526 | ARNT | 405 | RNAseq | 0.3268 | 0.1966 | |
| SRP193095 | ARNT | 405 | RNAseq | -0.0265 | 0.6916 | |
| SRP219564 | ARNT | 405 | RNAseq | 0.0895 | 0.6980 | |
| TCGA | ARNT | 405 | RNAseq | -0.0754 | 0.0990 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ARNT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARNT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARNT | 405 | 15 | 0 | 15 | |
| GSE20123 | ARNT | 405 | 15 | 0 | 15 | |
| GSE43470 | ARNT | 405 | 6 | 1 | 36 | |
| GSE46452 | ARNT | 405 | 2 | 1 | 56 | |
| GSE47630 | ARNT | 405 | 14 | 0 | 26 | |
| GSE54993 | ARNT | 405 | 1 | 3 | 66 | |
| GSE54994 | ARNT | 405 | 15 | 0 | 38 | |
| GSE60625 | ARNT | 405 | 0 | 0 | 11 | |
| GSE74703 | ARNT | 405 | 6 | 1 | 29 | |
| GSE74704 | ARNT | 405 | 7 | 0 | 13 | |
| TCGA | ARNT | 405 | 37 | 2 | 57 |
Total number of gains: 118; Total number of losses: 8; Total Number of normals: 362.
Somatic mutations of ARNT:
Generating mutation plots.
Highly correlated genes for ARNT:
Showing top 20/183 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARNT | HEATR5A | 0.806475 | 3 | 0 | 3 |
| ARNT | OXA1L | 0.749142 | 3 | 0 | 3 |
| ARNT | LIG3 | 0.74332 | 3 | 0 | 3 |
| ARNT | HIRA | 0.736993 | 3 | 0 | 3 |
| ARNT | UBTD2 | 0.726474 | 3 | 0 | 3 |
| ARNT | TRMT12 | 0.719443 | 3 | 0 | 3 |
| ARNT | ELAC2 | 0.713895 | 3 | 0 | 3 |
| ARNT | ZFYVE26 | 0.707971 | 3 | 0 | 3 |
| ARNT | C1orf50 | 0.707524 | 3 | 0 | 3 |
| ARNT | PPP6R3 | 0.706613 | 3 | 0 | 3 |
| ARNT | AMMECR1L | 0.706298 | 3 | 0 | 3 |
| ARNT | ZNF664 | 0.703272 | 3 | 0 | 3 |
| ARNT | NOSIP | 0.701643 | 4 | 0 | 3 |
| ARNT | ZNF146 | 0.6985 | 3 | 0 | 3 |
| ARNT | TRPM4 | 0.696888 | 3 | 0 | 3 |
| ARNT | ARL10 | 0.696728 | 3 | 0 | 3 |
| ARNT | PLEKHH1 | 0.693404 | 3 | 0 | 3 |
| ARNT | ATG14 | 0.69324 | 4 | 0 | 4 |
| ARNT | BABAM1 | 0.689297 | 3 | 0 | 3 |
| ARNT | AGBL5 | 0.688644 | 4 | 0 | 4 |
For details and further investigation, click here
