| Full name: death effector domain containing | Alias Symbol: DEFT|FLDED1|CASP8IP1|KE05|DEDD1 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 9191 | HGNC ID: HGNC:2755 | Ensembl Gene: ENSG00000158796 | OMIM ID: 606841 |
| Drug and gene relationship at DGIdb | |||
Expression of DEDD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEDD | 9191 | 215158_s_at | 0.2002 | 0.3814 | |
| GSE20347 | DEDD | 9191 | 215158_s_at | 0.0256 | 0.7168 | |
| GSE23400 | DEDD | 9191 | 215158_s_at | 0.1514 | 0.0004 | |
| GSE26886 | DEDD | 9191 | 215158_s_at | 0.0443 | 0.8332 | |
| GSE29001 | DEDD | 9191 | 215158_s_at | 0.1107 | 0.5722 | |
| GSE38129 | DEDD | 9191 | 215158_s_at | 0.0566 | 0.5018 | |
| GSE45670 | DEDD | 9191 | 215158_s_at | 0.1365 | 0.1182 | |
| GSE53622 | DEDD | 9191 | 27180 | 0.2037 | 0.0000 | |
| GSE53624 | DEDD | 9191 | 27180 | 0.2162 | 0.0007 | |
| GSE63941 | DEDD | 9191 | 215158_s_at | 0.8004 | 0.0077 | |
| GSE77861 | DEDD | 9191 | 215158_s_at | 0.2346 | 0.2164 | |
| GSE97050 | DEDD | 9191 | A_23_P74716 | 0.1396 | 0.6124 | |
| SRP007169 | DEDD | 9191 | RNAseq | -0.7039 | 0.0206 | |
| SRP008496 | DEDD | 9191 | RNAseq | -0.3538 | 0.0415 | |
| SRP064894 | DEDD | 9191 | RNAseq | 0.0954 | 0.4815 | |
| SRP133303 | DEDD | 9191 | RNAseq | 0.0723 | 0.6100 | |
| SRP159526 | DEDD | 9191 | RNAseq | 0.3444 | 0.1793 | |
| SRP193095 | DEDD | 9191 | RNAseq | 0.1978 | 0.0735 | |
| SRP219564 | DEDD | 9191 | RNAseq | 0.0556 | 0.8408 | |
| TCGA | DEDD | 9191 | RNAseq | 0.1302 | 0.0102 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEDD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEDD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEDD | 9191 | 10 | 0 | 20 | |
| GSE20123 | DEDD | 9191 | 10 | 0 | 20 | |
| GSE43470 | DEDD | 9191 | 7 | 2 | 34 | |
| GSE46452 | DEDD | 9191 | 2 | 1 | 56 | |
| GSE47630 | DEDD | 9191 | 14 | 0 | 26 | |
| GSE54993 | DEDD | 9191 | 0 | 6 | 64 | |
| GSE54994 | DEDD | 9191 | 16 | 0 | 37 | |
| GSE60625 | DEDD | 9191 | 0 | 0 | 11 | |
| GSE74703 | DEDD | 9191 | 7 | 2 | 27 | |
| GSE74704 | DEDD | 9191 | 4 | 0 | 16 | |
| TCGA | DEDD | 9191 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of DEDD:
Generating mutation plots.
Highly correlated genes for DEDD:
Showing top 20/525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEDD | LIG3 | 0.834368 | 3 | 0 | 3 |
| DEDD | MYO9B | 0.812199 | 3 | 0 | 3 |
| DEDD | PACS1 | 0.805718 | 3 | 0 | 3 |
| DEDD | DOCK6 | 0.7925 | 3 | 0 | 3 |
| DEDD | CASKIN2 | 0.792475 | 3 | 0 | 3 |
| DEDD | KLHDC3 | 0.786014 | 3 | 0 | 3 |
| DEDD | KLHL36 | 0.783633 | 3 | 0 | 3 |
| DEDD | TATDN2 | 0.766757 | 3 | 0 | 3 |
| DEDD | NACC1 | 0.765491 | 3 | 0 | 3 |
| DEDD | DCAF7 | 0.759027 | 3 | 0 | 3 |
| DEDD | PRDM15 | 0.753515 | 3 | 0 | 3 |
| DEDD | DOLK | 0.752304 | 3 | 0 | 3 |
| DEDD | FAM161A | 0.750824 | 3 | 0 | 3 |
| DEDD | GPS2 | 0.749883 | 3 | 0 | 3 |
| DEDD | MRPL38 | 0.741716 | 4 | 0 | 4 |
| DEDD | NUB1 | 0.739849 | 3 | 0 | 3 |
| DEDD | TRIM47 | 0.739104 | 3 | 0 | 3 |
| DEDD | CDK5RAP2 | 0.738685 | 3 | 0 | 3 |
| DEDD | PI4KA | 0.737814 | 3 | 0 | 3 |
| DEDD | NUCKS1 | 0.735101 | 3 | 0 | 3 |
For details and further investigation, click here
