| Full name: LIM domain kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 3985 | HGNC ID: HGNC:6614 | Ensembl Gene: ENSG00000182541 | OMIM ID: 601988 |
| Drug and gene relationship at DGIdb | |||
LIMK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance | |
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of LIMK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIMK2 | 3985 | 202193_at | 0.2087 | 0.7908 | |
| GSE20347 | LIMK2 | 3985 | 202193_at | -0.3253 | 0.0631 | |
| GSE23400 | LIMK2 | 3985 | 210582_s_at | 0.0446 | 0.4797 | |
| GSE26886 | LIMK2 | 3985 | 202193_at | -0.7524 | 0.0065 | |
| GSE29001 | LIMK2 | 3985 | 202193_at | 0.0842 | 0.8048 | |
| GSE38129 | LIMK2 | 3985 | 202193_at | 0.1420 | 0.6004 | |
| GSE45670 | LIMK2 | 3985 | 202193_at | 0.4230 | 0.0042 | |
| GSE53622 | LIMK2 | 3985 | 73815 | -0.1001 | 0.4248 | |
| GSE53624 | LIMK2 | 3985 | 73815 | -0.3153 | 0.0000 | |
| GSE63941 | LIMK2 | 3985 | 202193_at | 0.0126 | 0.9880 | |
| GSE77861 | LIMK2 | 3985 | 202193_at | -0.1790 | 0.4590 | |
| GSE97050 | LIMK2 | 3985 | A_24_P353300 | 0.7669 | 0.2301 | |
| SRP007169 | LIMK2 | 3985 | RNAseq | -0.1503 | 0.6143 | |
| SRP008496 | LIMK2 | 3985 | RNAseq | -0.1199 | 0.5158 | |
| SRP064894 | LIMK2 | 3985 | RNAseq | 0.2322 | 0.2256 | |
| SRP133303 | LIMK2 | 3985 | RNAseq | 0.0515 | 0.7926 | |
| SRP159526 | LIMK2 | 3985 | RNAseq | -0.3115 | 0.1526 | |
| SRP193095 | LIMK2 | 3985 | RNAseq | -0.0753 | 0.5710 | |
| SRP219564 | LIMK2 | 3985 | RNAseq | 0.1521 | 0.8057 | |
| TCGA | LIMK2 | 3985 | RNAseq | 0.0819 | 0.1596 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LIMK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIMK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIMK2 | 3985 | 4 | 5 | 21 | |
| GSE20123 | LIMK2 | 3985 | 4 | 4 | 22 | |
| GSE43470 | LIMK2 | 3985 | 4 | 5 | 34 | |
| GSE46452 | LIMK2 | 3985 | 31 | 1 | 27 | |
| GSE47630 | LIMK2 | 3985 | 8 | 5 | 27 | |
| GSE54993 | LIMK2 | 3985 | 3 | 6 | 61 | |
| GSE54994 | LIMK2 | 3985 | 12 | 7 | 34 | |
| GSE60625 | LIMK2 | 3985 | 5 | 0 | 6 | |
| GSE74703 | LIMK2 | 3985 | 4 | 5 | 27 | |
| GSE74704 | LIMK2 | 3985 | 1 | 1 | 18 | |
| TCGA | LIMK2 | 3985 | 27 | 15 | 54 |
Total number of gains: 103; Total number of losses: 54; Total Number of normals: 331.
Somatic mutations of LIMK2:
Generating mutation plots.
Highly correlated genes for LIMK2:
Showing top 20/571 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIMK2 | TMEM186 | 0.770847 | 3 | 0 | 3 |
| LIMK2 | FAM83B | 0.733597 | 5 | 0 | 4 |
| LIMK2 | MAPK8IP3 | 0.715216 | 3 | 0 | 3 |
| LIMK2 | IRX3 | 0.714127 | 3 | 0 | 3 |
| LIMK2 | SERINC2 | 0.713941 | 4 | 0 | 3 |
| LIMK2 | TAX1BP3 | 0.711872 | 3 | 0 | 3 |
| LIMK2 | ELOVL1 | 0.708098 | 3 | 0 | 3 |
| LIMK2 | MARVELD2 | 0.706206 | 4 | 0 | 3 |
| LIMK2 | RAB38 | 0.702408 | 9 | 0 | 9 |
| LIMK2 | SLC25A10 | 0.701437 | 3 | 0 | 3 |
| LIMK2 | MRPL30 | 0.699172 | 4 | 0 | 4 |
| LIMK2 | APRT | 0.698093 | 5 | 0 | 4 |
| LIMK2 | SLC38A9 | 0.693573 | 5 | 0 | 4 |
| LIMK2 | STON2 | 0.693547 | 4 | 0 | 3 |
| LIMK2 | SEC11C | 0.692296 | 3 | 0 | 3 |
| LIMK2 | PARP9 | 0.690747 | 3 | 0 | 3 |
| LIMK2 | GLOD4 | 0.687305 | 3 | 0 | 3 |
| LIMK2 | RNF149 | 0.683686 | 7 | 0 | 6 |
| LIMK2 | CDH1 | 0.683244 | 8 | 0 | 7 |
| LIMK2 | LACTB | 0.680097 | 4 | 0 | 3 |
For details and further investigation, click here
