| Full name: mitochondrial ribosomal protein L30 | Alias Symbol: MRP-L28|RPML28 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 51263 | HGNC ID: HGNC:14036 | Ensembl Gene: ENSG00000185414 | OMIM ID: 611838 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL30:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL30 | 51263 | 224971_at | 0.2473 | 0.5492 | |
| GSE26886 | MRPL30 | 51263 | 224971_at | -0.0796 | 0.6720 | |
| GSE45670 | MRPL30 | 51263 | 224971_at | 0.1873 | 0.3100 | |
| GSE53622 | MRPL30 | 51263 | 70075 | -0.0147 | 0.8424 | |
| GSE53624 | MRPL30 | 51263 | 70075 | 0.0273 | 0.6449 | |
| GSE63941 | MRPL30 | 51263 | 224971_at | 1.3540 | 0.0003 | |
| GSE77861 | MRPL30 | 51263 | 224971_at | -0.0983 | 0.6945 | |
| GSE97050 | MRPL30 | 51263 | A_24_P302695 | -0.1036 | 0.6735 | |
| SRP007169 | MRPL30 | 51263 | RNAseq | -0.5531 | 0.2023 | |
| SRP008496 | MRPL30 | 51263 | RNAseq | -0.4157 | 0.0600 | |
| SRP064894 | MRPL30 | 51263 | RNAseq | -0.1883 | 0.1537 | |
| SRP133303 | MRPL30 | 51263 | RNAseq | -0.0008 | 0.9946 | |
| SRP159526 | MRPL30 | 51263 | RNAseq | -0.1517 | 0.4809 | |
| SRP193095 | MRPL30 | 51263 | RNAseq | -0.5535 | 0.0000 | |
| SRP219564 | MRPL30 | 51263 | RNAseq | -0.2762 | 0.3161 | |
| TCGA | MRPL30 | 51263 | RNAseq | 0.0885 | 0.0832 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRPL30 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL30:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL30 | 51263 | 6 | 2 | 22 | |
| GSE20123 | MRPL30 | 51263 | 6 | 2 | 22 | |
| GSE43470 | MRPL30 | 51263 | 3 | 1 | 39 | |
| GSE46452 | MRPL30 | 51263 | 2 | 3 | 54 | |
| GSE47630 | MRPL30 | 51263 | 7 | 0 | 33 | |
| GSE54993 | MRPL30 | 51263 | 0 | 6 | 64 | |
| GSE54994 | MRPL30 | 51263 | 10 | 0 | 43 | |
| GSE60625 | MRPL30 | 51263 | 0 | 3 | 8 | |
| GSE74703 | MRPL30 | 51263 | 3 | 1 | 32 | |
| GSE74704 | MRPL30 | 51263 | 4 | 1 | 15 | |
| TCGA | MRPL30 | 51263 | 34 | 4 | 58 |
Total number of gains: 75; Total number of losses: 23; Total Number of normals: 390.
Somatic mutations of MRPL30:
Generating mutation plots.
Highly correlated genes for MRPL30:
Showing top 20/294 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL30 | EIF2S2 | 0.836221 | 3 | 0 | 3 |
| MRPL30 | UBL5 | 0.810411 | 3 | 0 | 3 |
| MRPL30 | AP1G1 | 0.80092 | 3 | 0 | 3 |
| MRPL30 | TMCO6 | 0.790388 | 3 | 0 | 3 |
| MRPL30 | EIF4E | 0.779768 | 3 | 0 | 3 |
| MRPL30 | REL | 0.775769 | 3 | 0 | 3 |
| MRPL30 | COPS2 | 0.772474 | 3 | 0 | 3 |
| MRPL30 | SORD | 0.769018 | 3 | 0 | 3 |
| MRPL30 | DNAJA2 | 0.767189 | 3 | 0 | 3 |
| MRPL30 | SEC61G | 0.76606 | 3 | 0 | 3 |
| MRPL30 | EIF3I | 0.764506 | 3 | 0 | 3 |
| MRPL30 | IRAK2 | 0.758957 | 3 | 0 | 3 |
| MRPL30 | PRPF38A | 0.757601 | 3 | 0 | 3 |
| MRPL30 | MPP6 | 0.750773 | 3 | 0 | 3 |
| MRPL30 | HSPA4 | 0.749794 | 3 | 0 | 3 |
| MRPL30 | DNAJA3 | 0.748863 | 3 | 0 | 3 |
| MRPL30 | RPL26L1 | 0.748569 | 4 | 0 | 3 |
| MRPL30 | CLDND1 | 0.745528 | 3 | 0 | 3 |
| MRPL30 | CHCHD2 | 0.739416 | 3 | 0 | 3 |
| MRPL30 | CNOT1 | 0.735597 | 4 | 0 | 3 |
For details and further investigation, click here
