| Full name: adenine phosphoribosyltransferase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 353 | HGNC ID: HGNC:626 | Ensembl Gene: ENSG00000198931 | OMIM ID: 102600 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of APRT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APRT | 353 | 213892_s_at | 0.2050 | 0.5177 | |
| GSE20347 | APRT | 353 | 213892_s_at | -0.1819 | 0.1689 | |
| GSE23400 | APRT | 353 | 213892_s_at | 0.0589 | 0.5694 | |
| GSE26886 | APRT | 353 | 213892_s_at | 0.0554 | 0.7887 | |
| GSE29001 | APRT | 353 | 213892_s_at | -0.2443 | 0.5342 | |
| GSE38129 | APRT | 353 | 213892_s_at | 0.2149 | 0.2440 | |
| GSE45670 | APRT | 353 | 213892_s_at | -0.0877 | 0.5816 | |
| GSE53622 | APRT | 353 | 26286 | -0.2445 | 0.0089 | |
| GSE53624 | APRT | 353 | 26286 | 0.2002 | 0.0009 | |
| GSE63941 | APRT | 353 | 213892_s_at | 0.5446 | 0.3284 | |
| GSE77861 | APRT | 353 | 213892_s_at | -0.1290 | 0.6642 | |
| GSE97050 | APRT | 353 | A_33_P3360097 | 0.1669 | 0.6173 | |
| SRP007169 | APRT | 353 | RNAseq | -1.2131 | 0.0015 | |
| SRP008496 | APRT | 353 | RNAseq | -1.0443 | 0.0001 | |
| SRP064894 | APRT | 353 | RNAseq | -0.0792 | 0.8191 | |
| SRP133303 | APRT | 353 | RNAseq | 0.4200 | 0.2018 | |
| SRP159526 | APRT | 353 | RNAseq | 0.0684 | 0.8889 | |
| SRP193095 | APRT | 353 | RNAseq | -0.4670 | 0.0026 | |
| SRP219564 | APRT | 353 | RNAseq | -0.0592 | 0.8709 | |
| TCGA | APRT | 353 | RNAseq | 0.1015 | 0.1252 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by APRT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APRT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APRT | 353 | 4 | 3 | 23 | |
| GSE20123 | APRT | 353 | 4 | 3 | 23 | |
| GSE43470 | APRT | 353 | 1 | 13 | 29 | |
| GSE46452 | APRT | 353 | 38 | 1 | 20 | |
| GSE47630 | APRT | 353 | 11 | 9 | 20 | |
| GSE54993 | APRT | 353 | 3 | 4 | 63 | |
| GSE54994 | APRT | 353 | 9 | 11 | 33 | |
| GSE60625 | APRT | 353 | 4 | 0 | 7 | |
| GSE74703 | APRT | 353 | 1 | 9 | 26 | |
| GSE74704 | APRT | 353 | 3 | 2 | 15 | |
| TCGA | APRT | 353 | 28 | 15 | 53 |
Total number of gains: 106; Total number of losses: 70; Total Number of normals: 312.
Somatic mutations of APRT:
Generating mutation plots.
Highly correlated genes for APRT:
Showing top 20/469 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APRT | RNF149 | 0.748912 | 3 | 0 | 3 |
| APRT | CDC42BPG | 0.72771 | 3 | 0 | 3 |
| APRT | TMEM223 | 0.72177 | 3 | 0 | 3 |
| APRT | HM13 | 0.712489 | 4 | 0 | 3 |
| APRT | FAM83B | 0.711737 | 3 | 0 | 3 |
| APRT | TMSB10 | 0.703073 | 3 | 0 | 3 |
| APRT | LIMK2 | 0.698093 | 5 | 0 | 4 |
| APRT | PTPN3 | 0.694636 | 4 | 0 | 4 |
| APRT | CYB561 | 0.691797 | 4 | 0 | 4 |
| APRT | VSNL1 | 0.691635 | 4 | 0 | 4 |
| APRT | TSTD1 | 0.685064 | 3 | 0 | 3 |
| APRT | ASPM | 0.678409 | 3 | 0 | 3 |
| APRT | PSMB7 | 0.677559 | 3 | 0 | 3 |
| APRT | ZNF740 | 0.676202 | 3 | 0 | 3 |
| APRT | FAM83G | 0.675546 | 4 | 0 | 3 |
| APRT | MOGS | 0.67548 | 3 | 0 | 3 |
| APRT | SLC25A39 | 0.665785 | 5 | 0 | 4 |
| APRT | MRPL3 | 0.665527 | 3 | 0 | 3 |
| APRT | CLTA | 0.659281 | 3 | 0 | 3 |
| APRT | RPUSD1 | 0.658648 | 3 | 0 | 3 |
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