CDH1

 

Full name: cadherin 1 Alias Symbol: uvomorulin|CD324
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 999 HGNC ID: HGNC:1748 Ensembl Gene: ENSG00000039068 OMIM ID: 192090
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 6/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CDH1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04520Adherens junction
hsa05100Bacterial invasion of epithelial cells
hsa05130Pathogenic Escherichia coli infection
hsa05216Thyroid cancer

 

Expression of CDH1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDH1 999 201131_s_at 0.2267 0.8254
GSE20347 CDH1 999 201131_s_at -0.3223 0.0089
GSE23400 CDH1 999 201131_s_at -0.0922 0.5475
GSE26886 CDH1 999 201131_s_at -0.5123 0.0034
GSE29001 CDH1 999 201131_s_at -0.1766 0.2624
GSE38129 CDH1 999 201131_s_at 0.5434 0.2311
GSE45670 CDH1 999 201131_s_at 0.4041 0.0003
GSE53622 CDH1 999 82040 -0.4314 0.0125
GSE53624 CDH1 999 23446 -0.7522 0.0000
GSE63941 CDH1 999 201131_s_at 7.7626 0.0000
GSE77861 CDH1 999 201131_s_at 0.2624 0.1067
GSE97050 CDH1 999 A_23_P206359 0.9587 0.4119
SRP007169 CDH1 999 RNAseq -0.3508 0.2469
SRP008496 CDH1 999 RNAseq -0.6583 0.0263
SRP064894 CDH1 999 RNAseq -0.6600 0.0906
SRP133303 CDH1 999 RNAseq -0.0630 0.7691
SRP159526 CDH1 999 RNAseq -0.0092 0.9736
SRP193095 CDH1 999 RNAseq -0.6046 0.0000
SRP219564 CDH1 999 RNAseq -0.7836 0.4761
TCGA CDH1 999 RNAseq 0.1758 0.1396

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CDH1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDH1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDH1 999 9 1 20
GSE20123 CDH1 999 9 1 20
GSE43470 CDH1 999 2 8 33
GSE46452 CDH1 999 38 1 20
GSE47630 CDH1 999 11 8 21
GSE54993 CDH1 999 2 4 64
GSE54994 CDH1 999 8 10 35
GSE60625 CDH1 999 4 0 7
GSE74703 CDH1 999 2 5 29
GSE74704 CDH1 999 5 0 15
TCGA CDH1 999 31 12 53

Total number of gains: 121; Total number of losses: 50; Total Number of normals: 317.  

 

Somatic mutations of CDH1:

 

Generating mutation plots.

 

Highly correlated genes for CDH1:

 

Showing top 20/672 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDH1NIPAL10.77373303
CDH1ZNF1650.752029303
CDH1IRF60.750865606
CDH1FAM83H0.746645505
CDH1FAM110C0.73274505
CDH1CTNND10.730563303
CDH1SORD0.72074606
CDH1SH3RF20.718715505
CDH1DMKN0.715118606
CDH1FAM160A10.713449606
CDH1FXYD30.705917705
CDH1LAD10.7027751008
CDH1PTBP30.701818805
CDH1IRX30.700257403
CDH1ARHGAP270.698489706
CDH1F11R0.698183806
CDH1SPINT20.6957761009
CDH1SYTL10.695667706
CDH1CDKN1B0.69261303
CDH1MARVELD20.690198806

For details and further investigation, click here