| Full name: SEC11 homolog C, signal peptidase complex subunit | Alias Symbol: SPC21|SPCS4C | ||
| Type: protein-coding gene | Cytoband: 18q21.32 | ||
| Entrez ID: 90701 | HGNC ID: HGNC:23400 | Ensembl Gene: ENSG00000166562 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SEC11C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC11C | 90701 | 223299_at | 0.0922 | 0.9168 | |
| GSE26886 | SEC11C | 90701 | 223299_at | -0.5266 | 0.0369 | |
| GSE45670 | SEC11C | 90701 | 223299_at | -0.0785 | 0.7183 | |
| GSE53622 | SEC11C | 90701 | 87679 | -0.4924 | 0.0000 | |
| GSE53624 | SEC11C | 90701 | 87679 | -0.3932 | 0.0000 | |
| GSE63941 | SEC11C | 90701 | 223299_at | -0.6780 | 0.1817 | |
| GSE77861 | SEC11C | 90701 | 223299_at | -0.2119 | 0.4471 | |
| GSE97050 | SEC11C | 90701 | A_23_P208009 | 0.4296 | 0.3475 | |
| SRP007169 | SEC11C | 90701 | RNAseq | -1.1580 | 0.0079 | |
| SRP008496 | SEC11C | 90701 | RNAseq | -1.1550 | 0.0001 | |
| SRP064894 | SEC11C | 90701 | RNAseq | -0.6755 | 0.0290 | |
| SRP133303 | SEC11C | 90701 | RNAseq | -0.2732 | 0.3917 | |
| SRP159526 | SEC11C | 90701 | RNAseq | 0.0693 | 0.8911 | |
| SRP193095 | SEC11C | 90701 | RNAseq | -0.5869 | 0.0036 | |
| SRP219564 | SEC11C | 90701 | RNAseq | -0.0936 | 0.6696 | |
| TCGA | SEC11C | 90701 | RNAseq | -0.3320 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SEC11C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC11C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC11C | 90701 | 2 | 8 | 20 | |
| GSE20123 | SEC11C | 90701 | 2 | 8 | 20 | |
| GSE43470 | SEC11C | 90701 | 0 | 5 | 38 | |
| GSE46452 | SEC11C | 90701 | 1 | 26 | 32 | |
| GSE47630 | SEC11C | 90701 | 5 | 20 | 15 | |
| GSE54993 | SEC11C | 90701 | 10 | 0 | 60 | |
| GSE54994 | SEC11C | 90701 | 0 | 18 | 35 | |
| GSE60625 | SEC11C | 90701 | 0 | 4 | 7 | |
| GSE74703 | SEC11C | 90701 | 0 | 5 | 31 | |
| GSE74704 | SEC11C | 90701 | 2 | 5 | 13 | |
| TCGA | SEC11C | 90701 | 9 | 44 | 43 |
Total number of gains: 31; Total number of losses: 143; Total Number of normals: 314.
Somatic mutations of SEC11C:
Generating mutation plots.
Highly correlated genes for SEC11C:
Showing top 20/318 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC11C | CASP4 | 0.751183 | 3 | 0 | 3 |
| SEC11C | UBE2D3 | 0.74056 | 3 | 0 | 3 |
| SEC11C | PEX3 | 0.73808 | 3 | 0 | 3 |
| SEC11C | PLAA | 0.71819 | 3 | 0 | 3 |
| SEC11C | TET2 | 0.707458 | 3 | 0 | 3 |
| SEC11C | PEX2 | 0.704386 | 5 | 0 | 4 |
| SEC11C | BACH2 | 0.702001 | 3 | 0 | 3 |
| SEC11C | SAR1A | 0.697375 | 3 | 0 | 3 |
| SEC11C | TRPV2 | 0.696777 | 3 | 0 | 3 |
| SEC11C | SMG8 | 0.695735 | 3 | 0 | 3 |
| SEC11C | PIM2 | 0.695449 | 3 | 0 | 3 |
| SEC11C | ATP6V1H | 0.69422 | 4 | 0 | 3 |
| SEC11C | LIMK2 | 0.692296 | 3 | 0 | 3 |
| SEC11C | SAMM50 | 0.691893 | 3 | 0 | 3 |
| SEC11C | PTPN13 | 0.686392 | 3 | 0 | 3 |
| SEC11C | SURF4 | 0.685031 | 4 | 0 | 3 |
| SEC11C | IARS2 | 0.681267 | 3 | 0 | 3 |
| SEC11C | GTF2A2 | 0.678223 | 3 | 0 | 3 |
| SEC11C | ZNF208 | 0.677866 | 3 | 0 | 3 |
| SEC11C | RPL19 | 0.677093 | 3 | 0 | 3 |
For details and further investigation, click here
