| Full name: mitogen-activated protein kinase 8 interacting protein 3 | Alias Symbol: KIAA1066|JSAP1|JIP3|syd | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 23162 | HGNC ID: HGNC:6884 | Ensembl Gene: ENSG00000138834 | OMIM ID: 605431 |
| Drug and gene relationship at DGIdb | |||
MAPK8IP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of MAPK8IP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPK8IP3 | 23162 | 213178_s_at | 0.1445 | 0.6490 | |
| GSE20347 | MAPK8IP3 | 23162 | 213177_at | 0.0005 | 0.9967 | |
| GSE23400 | MAPK8IP3 | 23162 | 213178_s_at | 0.1809 | 0.0004 | |
| GSE26886 | MAPK8IP3 | 23162 | 213177_at | 0.2158 | 0.1269 | |
| GSE29001 | MAPK8IP3 | 23162 | 213178_s_at | 0.0633 | 0.8875 | |
| GSE38129 | MAPK8IP3 | 23162 | 213178_s_at | -0.0163 | 0.9111 | |
| GSE45670 | MAPK8IP3 | 23162 | 213178_s_at | 0.1691 | 0.1824 | |
| GSE53622 | MAPK8IP3 | 23162 | 45413 | -0.0909 | 0.1966 | |
| GSE53624 | MAPK8IP3 | 23162 | 45413 | -0.4052 | 0.0000 | |
| GSE63941 | MAPK8IP3 | 23162 | 213178_s_at | 0.3952 | 0.3490 | |
| GSE77861 | MAPK8IP3 | 23162 | 213178_s_at | 0.0610 | 0.7721 | |
| GSE97050 | MAPK8IP3 | 23162 | A_33_P3279841 | 0.1349 | 0.5755 | |
| SRP007169 | MAPK8IP3 | 23162 | RNAseq | 0.4366 | 0.4087 | |
| SRP064894 | MAPK8IP3 | 23162 | RNAseq | 0.3535 | 0.1292 | |
| SRP133303 | MAPK8IP3 | 23162 | RNAseq | -0.0010 | 0.9946 | |
| SRP159526 | MAPK8IP3 | 23162 | RNAseq | 0.0113 | 0.9652 | |
| SRP193095 | MAPK8IP3 | 23162 | RNAseq | 0.7419 | 0.0001 | |
| SRP219564 | MAPK8IP3 | 23162 | RNAseq | 0.5072 | 0.1827 | |
| TCGA | MAPK8IP3 | 23162 | RNAseq | -0.0671 | 0.2466 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAPK8IP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPK8IP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPK8IP3 | 23162 | 5 | 5 | 20 | |
| GSE20123 | MAPK8IP3 | 23162 | 5 | 4 | 21 | |
| GSE43470 | MAPK8IP3 | 23162 | 4 | 7 | 32 | |
| GSE46452 | MAPK8IP3 | 23162 | 38 | 1 | 20 | |
| GSE47630 | MAPK8IP3 | 23162 | 13 | 6 | 21 | |
| GSE54993 | MAPK8IP3 | 23162 | 3 | 5 | 62 | |
| GSE54994 | MAPK8IP3 | 23162 | 5 | 9 | 39 | |
| GSE60625 | MAPK8IP3 | 23162 | 4 | 0 | 7 | |
| GSE74703 | MAPK8IP3 | 23162 | 4 | 5 | 27 | |
| GSE74704 | MAPK8IP3 | 23162 | 3 | 2 | 15 | |
| TCGA | MAPK8IP3 | 23162 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of MAPK8IP3:
Generating mutation plots.
Highly correlated genes for MAPK8IP3:
Showing top 20/377 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPK8IP3 | SARDH | 0.806878 | 3 | 0 | 3 |
| MAPK8IP3 | TNPO1 | 0.750638 | 3 | 0 | 3 |
| MAPK8IP3 | PHF23 | 0.745795 | 3 | 0 | 3 |
| MAPK8IP3 | ZNF787 | 0.737736 | 4 | 0 | 4 |
| MAPK8IP3 | MAST1 | 0.728878 | 3 | 0 | 3 |
| MAPK8IP3 | U2AF2 | 0.728225 | 3 | 0 | 3 |
| MAPK8IP3 | GGT5 | 0.725325 | 3 | 0 | 3 |
| MAPK8IP3 | CLEC11A | 0.722061 | 3 | 0 | 3 |
| MAPK8IP3 | NGF | 0.721371 | 3 | 0 | 3 |
| MAPK8IP3 | HKDC1 | 0.715789 | 3 | 0 | 3 |
| MAPK8IP3 | LIMK2 | 0.715216 | 3 | 0 | 3 |
| MAPK8IP3 | TAF6L | 0.714413 | 3 | 0 | 3 |
| MAPK8IP3 | FOXRED2 | 0.713816 | 3 | 0 | 3 |
| MAPK8IP3 | GMEB2 | 0.712115 | 3 | 0 | 3 |
| MAPK8IP3 | XPNPEP2 | 0.708819 | 3 | 0 | 3 |
| MAPK8IP3 | SIDT2 | 0.701679 | 3 | 0 | 3 |
| MAPK8IP3 | WIPI2 | 0.69994 | 3 | 0 | 3 |
| MAPK8IP3 | ZNF628 | 0.697478 | 3 | 0 | 3 |
| MAPK8IP3 | CRMP1 | 0.696954 | 3 | 0 | 3 |
| MAPK8IP3 | GTPBP1 | 0.695676 | 3 | 0 | 3 |
For details and further investigation, click here
