| Full name: LDL receptor related protein 2 | Alias Symbol: gp330|DBS | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 4036 | HGNC ID: HGNC:6694 | Ensembl Gene: ENSG00000081479 | OMIM ID: 600073 |
| Drug and gene relationship at DGIdb | |||
LRP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of LRP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP2 | 4036 | 230863_at | -0.1052 | 0.6753 | |
| GSE20347 | LRP2 | 4036 | 205710_at | 0.1272 | 0.0329 | |
| GSE23400 | LRP2 | 4036 | 205710_at | -0.0163 | 0.5539 | |
| GSE26886 | LRP2 | 4036 | 230863_at | -0.2651 | 0.0662 | |
| GSE29001 | LRP2 | 4036 | 205710_at | 0.0114 | 0.9404 | |
| GSE38129 | LRP2 | 4036 | 205710_at | 0.0105 | 0.8784 | |
| GSE45670 | LRP2 | 4036 | 205710_at | 0.0453 | 0.6111 | |
| GSE63941 | LRP2 | 4036 | 205710_at | 0.1984 | 0.2449 | |
| GSE77861 | LRP2 | 4036 | 230863_at | -0.2066 | 0.0630 | |
| GSE97050 | LRP2 | 4036 | A_33_P3244728 | -0.4509 | 0.2204 | |
| SRP133303 | LRP2 | 4036 | RNAseq | 0.8190 | 0.0244 | |
| SRP219564 | LRP2 | 4036 | RNAseq | -0.0314 | 0.9477 | |
| TCGA | LRP2 | 4036 | RNAseq | 0.9590 | 0.1132 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LRP2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LRP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP2 | 4036 | 8 | 0 | 22 | |
| GSE20123 | LRP2 | 4036 | 8 | 0 | 22 | |
| GSE43470 | LRP2 | 4036 | 5 | 1 | 37 | |
| GSE46452 | LRP2 | 4036 | 1 | 4 | 54 | |
| GSE47630 | LRP2 | 4036 | 5 | 3 | 32 | |
| GSE54993 | LRP2 | 4036 | 0 | 5 | 65 | |
| GSE54994 | LRP2 | 4036 | 10 | 3 | 40 | |
| GSE60625 | LRP2 | 4036 | 0 | 3 | 8 | |
| GSE74703 | LRP2 | 4036 | 4 | 1 | 31 | |
| GSE74704 | LRP2 | 4036 | 5 | 0 | 15 | |
| TCGA | LRP2 | 4036 | 24 | 10 | 62 |
Total number of gains: 70; Total number of losses: 30; Total Number of normals: 388.
Somatic mutations of LRP2:
Generating mutation plots.
Highly correlated genes for LRP2:
Showing top 20/341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP2 | LINC01192 | 0.710701 | 4 | 0 | 3 |
| LRP2 | PDK4 | 0.663503 | 4 | 0 | 3 |
| LRP2 | ZNF135 | 0.663356 | 4 | 0 | 3 |
| LRP2 | SLC26A7 | 0.662121 | 3 | 0 | 3 |
| LRP2 | IL1RAPL2 | 0.653646 | 4 | 0 | 4 |
| LRP2 | G6PC | 0.653404 | 4 | 0 | 4 |
| LRP2 | STXBP6 | 0.640983 | 3 | 0 | 3 |
| LRP2 | LHX3 | 0.637587 | 4 | 0 | 4 |
| LRP2 | CALCOCO1 | 0.630215 | 3 | 0 | 3 |
| LRP2 | NXPE4 | 0.628639 | 7 | 0 | 5 |
| LRP2 | KCNB2 | 0.6201 | 6 | 0 | 5 |
| LRP2 | KLHL4 | 0.62003 | 3 | 0 | 3 |
| LRP2 | KLK4 | 0.618596 | 4 | 0 | 3 |
| LRP2 | CDH10 | 0.614761 | 6 | 0 | 5 |
| LRP2 | CNGB3 | 0.613606 | 5 | 0 | 5 |
| LRP2 | LINC00930 | 0.612701 | 4 | 0 | 3 |
| LRP2 | CCDC7 | 0.610405 | 6 | 0 | 5 |
| LRP2 | GPR82 | 0.609574 | 4 | 0 | 3 |
| LRP2 | FGF14 | 0.609283 | 3 | 0 | 3 |
| LRP2 | DNASE2B | 0.606951 | 3 | 0 | 3 |
For details and further investigation, click here
