| Full name: cyclic nucleotide gated channel subunit beta 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 54714 | HGNC ID: HGNC:2153 | Ensembl Gene: ENSG00000170289 | OMIM ID: 605080 |
| Drug and gene relationship at DGIdb | |||
CNGB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway |
Expression of CNGB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNGB3 | 54714 | 220304_s_at | 0.1885 | 0.4359 | |
| GSE20347 | CNGB3 | 54714 | 220304_s_at | 0.1145 | 0.1567 | |
| GSE23400 | CNGB3 | 54714 | 220304_s_at | -0.0800 | 0.0074 | |
| GSE26886 | CNGB3 | 54714 | 220304_s_at | 0.0850 | 0.4765 | |
| GSE29001 | CNGB3 | 54714 | 220304_s_at | -0.0549 | 0.8217 | |
| GSE38129 | CNGB3 | 54714 | 220304_s_at | 0.0011 | 0.9927 | |
| GSE45670 | CNGB3 | 54714 | 220304_s_at | 0.1613 | 0.0185 | |
| GSE53622 | CNGB3 | 54714 | 1075 | 1.3428 | 0.0000 | |
| GSE53624 | CNGB3 | 54714 | 1075 | 2.1767 | 0.0000 | |
| GSE63941 | CNGB3 | 54714 | 220304_s_at | 0.4179 | 0.0055 | |
| GSE77861 | CNGB3 | 54714 | 220304_s_at | 0.0136 | 0.9211 | |
| GSE97050 | CNGB3 | 54714 | A_23_P216376 | 0.2556 | 0.2928 | |
| TCGA | CNGB3 | 54714 | RNAseq | 2.8613 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CNGB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNGB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNGB3 | 54714 | 14 | 1 | 15 | |
| GSE20123 | CNGB3 | 54714 | 16 | 1 | 13 | |
| GSE43470 | CNGB3 | 54714 | 19 | 1 | 23 | |
| GSE46452 | CNGB3 | 54714 | 21 | 0 | 38 | |
| GSE47630 | CNGB3 | 54714 | 23 | 0 | 17 | |
| GSE54993 | CNGB3 | 54714 | 0 | 20 | 50 | |
| GSE54994 | CNGB3 | 54714 | 33 | 1 | 19 | |
| GSE60625 | CNGB3 | 54714 | 0 | 4 | 7 | |
| GSE74703 | CNGB3 | 54714 | 16 | 1 | 19 | |
| GSE74704 | CNGB3 | 54714 | 10 | 0 | 10 | |
| TCGA | CNGB3 | 54714 | 54 | 2 | 40 |
Total number of gains: 206; Total number of losses: 31; Total Number of normals: 251.
Somatic mutations of CNGB3:
Generating mutation plots.
Highly correlated genes for CNGB3:
Showing top 20/899 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNGB3 | MEI1 | 0.755602 | 3 | 0 | 3 |
| CNGB3 | SHANK1 | 0.747499 | 3 | 0 | 3 |
| CNGB3 | OR10H3 | 0.741563 | 5 | 0 | 5 |
| CNGB3 | TRPM3 | 0.734243 | 6 | 0 | 5 |
| CNGB3 | PGC | 0.733113 | 4 | 0 | 4 |
| CNGB3 | CLCA1 | 0.731019 | 4 | 0 | 4 |
| CNGB3 | TDRD1 | 0.730995 | 5 | 0 | 5 |
| CNGB3 | IFNA4 | 0.724426 | 6 | 0 | 6 |
| CNGB3 | ABCA4 | 0.724167 | 5 | 0 | 5 |
| CNGB3 | BTNL2 | 0.714675 | 5 | 0 | 4 |
| CNGB3 | KLK2 | 0.714372 | 5 | 0 | 4 |
| CNGB3 | PRAMEF12 | 0.708737 | 5 | 0 | 5 |
| CNGB3 | KLHL34 | 0.706885 | 3 | 0 | 3 |
| CNGB3 | DNASE1L2 | 0.706788 | 3 | 0 | 3 |
| CNGB3 | KIR3DL3 | 0.705741 | 8 | 0 | 7 |
| CNGB3 | TNR | 0.70482 | 6 | 0 | 5 |
| CNGB3 | SLC17A4 | 0.702383 | 5 | 0 | 5 |
| CNGB3 | CHTF8 | 0.700707 | 3 | 0 | 3 |
| CNGB3 | ZNF446 | 0.700411 | 4 | 0 | 4 |
| CNGB3 | NOX5 | 0.699802 | 5 | 0 | 5 |
For details and further investigation, click here
