PDK4

 

Full name: pyruvate dehydrogenase kinase 4 Alias Symbol: 
Type: protein-coding gene Cytoband: 7q21.3
Entrez ID: 5166 HGNC ID: HGNC:8812 Ensembl Gene: ENSG00000004799 OMIM ID: 602527
Drug and gene relationship at DGIdb

 

Expression of PDK4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDK4 5166 225207_at -2.8254 0.1175
GSE20347 PDK4 5166 205960_at 0.0010 0.9908
GSE23400 PDK4 5166 205960_at -0.2487 0.0017
GSE26886 PDK4 5166 225207_at 0.4226 0.5272
GSE29001 PDK4 5166 205960_at 0.0124 0.9434
GSE38129 PDK4 5166 205960_at -0.1303 0.0881
GSE45670 PDK4 5166 225207_at -5.6622 0.0000
GSE53622 PDK4 5166 90644 -3.1923 0.0000
GSE53624 PDK4 5166 90644 -3.1551 0.0000
GSE63941 PDK4 5166 225207_at -3.4653 0.0050
GSE77861 PDK4 5166 205960_at -0.0750 0.4227
GSE97050 PDK4 5166 A_24_P243749 -1.0813 0.1213
SRP064894 PDK4 5166 RNAseq -1.7496 0.0049
SRP133303 PDK4 5166 RNAseq -1.8396 0.0383
SRP159526 PDK4 5166 RNAseq -2.6156 0.0001
SRP193095 PDK4 5166 RNAseq -1.4564 0.0065
SRP219564 PDK4 5166 RNAseq -2.3172 0.0075
TCGA PDK4 5166 RNAseq -1.7601 0.0000

Upregulated datasets: 0; Downregulated datasets: 10.  

 

Survival by PDK4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDK4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDK4 5166 13 0 17
GSE20123 PDK4 5166 13 0 17
GSE43470 PDK4 5166 8 1 34
GSE46452 PDK4 5166 12 0 47
GSE47630 PDK4 5166 8 2 30
GSE54993 PDK4 5166 1 9 60
GSE54994 PDK4 5166 16 3 34
GSE60625 PDK4 5166 0 5 6
GSE74703 PDK4 5166 7 1 28
GSE74704 PDK4 5166 9 0 11
TCGA PDK4 5166 55 4 37

Total number of gains: 142; Total number of losses: 25; Total Number of normals: 321.  

 

Somatic mutations of PDK4:

 

Generating mutation plots.

 

Highly correlated genes for PDK4:

 

Showing top 20/961 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDK4MYZAP0.819602303
PDK4ANGPTL10.801787504
PDK4RBFOX30.80037303
PDK4SLMAP0.798839404
PDK4NFIA0.789776404
PDK4LINC010820.785579505
PDK4FRMD30.772069404
PDK4ZNF5680.770173303
PDK4FENDRR0.769609505
PDK4ASPA0.764321706
PDK4LRRK20.763403505
PDK4GCNT40.763339404
PDK4TCF210.762898707
PDK4KCNT20.761315505
PDK4SMTNL20.760261404
PDK4RAI20.759918909
PDK4ADAMTS9-AS20.756463505
PDK4C70.754399808
PDK4OGN0.752616706
PDK4ABCA80.743701807

For details and further investigation, click here