| Full name: LDL receptor related protein 6 | Alias Symbol: ADCAD2 | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 4040 | HGNC ID: HGNC:6698 | Ensembl Gene: ENSG00000070018 | OMIM ID: 603507 |
| Drug and gene relationship at DGIdb | |||
LRP6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa04310 | Wnt signaling pathway |
Expression of LRP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP6 | 4040 | 225745_at | 0.3328 | 0.5311 | |
| GSE20347 | LRP6 | 4040 | 205606_at | 0.3645 | 0.0686 | |
| GSE23400 | LRP6 | 4040 | 205606_at | -0.0331 | 0.4561 | |
| GSE26886 | LRP6 | 4040 | 205606_at | 0.5667 | 0.0111 | |
| GSE29001 | LRP6 | 4040 | 205606_at | -0.0945 | 0.7322 | |
| GSE38129 | LRP6 | 4040 | 205606_at | 0.1830 | 0.3714 | |
| GSE45670 | LRP6 | 4040 | 225745_at | -0.2468 | 0.4546 | |
| GSE53622 | LRP6 | 4040 | 8818 | 0.2570 | 0.0434 | |
| GSE53624 | LRP6 | 4040 | 8818 | 0.4625 | 0.0000 | |
| GSE63941 | LRP6 | 4040 | 225745_at | -1.4585 | 0.0054 | |
| GSE77861 | LRP6 | 4040 | 205606_at | 0.4104 | 0.0665 | |
| GSE97050 | LRP6 | 4040 | A_33_P3306948 | -0.2698 | 0.2332 | |
| SRP007169 | LRP6 | 4040 | RNAseq | 1.8226 | 0.0001 | |
| SRP008496 | LRP6 | 4040 | RNAseq | 2.3699 | 0.0000 | |
| SRP064894 | LRP6 | 4040 | RNAseq | 0.0584 | 0.7614 | |
| SRP133303 | LRP6 | 4040 | RNAseq | 0.4123 | 0.0032 | |
| SRP159526 | LRP6 | 4040 | RNAseq | 1.6600 | 0.0017 | |
| SRP193095 | LRP6 | 4040 | RNAseq | 0.3354 | 0.0342 | |
| SRP219564 | LRP6 | 4040 | RNAseq | 0.0554 | 0.8739 | |
| TCGA | LRP6 | 4040 | RNAseq | -0.1585 | 0.0298 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by LRP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP6 | 4040 | 6 | 2 | 22 | |
| GSE20123 | LRP6 | 4040 | 6 | 2 | 22 | |
| GSE43470 | LRP6 | 4040 | 10 | 4 | 29 | |
| GSE46452 | LRP6 | 4040 | 10 | 1 | 48 | |
| GSE47630 | LRP6 | 4040 | 13 | 2 | 25 | |
| GSE54993 | LRP6 | 4040 | 2 | 9 | 59 | |
| GSE54994 | LRP6 | 4040 | 10 | 2 | 41 | |
| GSE60625 | LRP6 | 4040 | 0 | 1 | 10 | |
| GSE74703 | LRP6 | 4040 | 9 | 3 | 24 | |
| GSE74704 | LRP6 | 4040 | 4 | 1 | 15 | |
| TCGA | LRP6 | 4040 | 39 | 7 | 50 |
Total number of gains: 109; Total number of losses: 34; Total Number of normals: 345.
Somatic mutations of LRP6:
Generating mutation plots.
Highly correlated genes for LRP6:
Showing top 20/733 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP6 | FAN1 | 0.788511 | 3 | 0 | 3 |
| LRP6 | BTG2 | 0.778351 | 3 | 0 | 3 |
| LRP6 | GLS | 0.766073 | 3 | 0 | 3 |
| LRP6 | MED17 | 0.750356 | 3 | 0 | 3 |
| LRP6 | CAMKK2 | 0.749323 | 3 | 0 | 3 |
| LRP6 | KDSR | 0.748001 | 3 | 0 | 3 |
| LRP6 | UQCR10 | 0.743798 | 3 | 0 | 3 |
| LRP6 | NOM1 | 0.73952 | 3 | 0 | 3 |
| LRP6 | ABHD2 | 0.730743 | 4 | 0 | 4 |
| LRP6 | TRIM37 | 0.730054 | 4 | 0 | 4 |
| LRP6 | FGFR1OP2 | 0.730039 | 4 | 0 | 4 |
| LRP6 | C20orf194 | 0.729472 | 3 | 0 | 3 |
| LRP6 | RNF26 | 0.721959 | 3 | 0 | 3 |
| LRP6 | C1orf122 | 0.721482 | 3 | 0 | 3 |
| LRP6 | FIBP | 0.715843 | 3 | 0 | 3 |
| LRP6 | C3orf70 | 0.711395 | 3 | 0 | 3 |
| LRP6 | CTPS2 | 0.710567 | 4 | 0 | 4 |
| LRP6 | MAN2B1 | 0.710473 | 3 | 0 | 3 |
| LRP6 | KREMEN1 | 0.709026 | 3 | 0 | 3 |
| LRP6 | SCAND1 | 0.703099 | 3 | 0 | 3 |
For details and further investigation, click here
