| Full name: calcium/calmodulin dependent protein kinase kinase 2 | Alias Symbol: CAMKK|KIAA0787|CAMKKB|MGC15254 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 10645 | HGNC ID: HGNC:1470 | Ensembl Gene: ENSG00000110931 | OMIM ID: 615002 |
| Drug and gene relationship at DGIdb | |||
CAMKK2 involved pathways:
Expression of CAMKK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAMKK2 | 10645 | 213812_s_at | 0.7006 | 0.3334 | |
| GSE20347 | CAMKK2 | 10645 | 213812_s_at | 0.5469 | 0.0004 | |
| GSE23400 | CAMKK2 | 10645 | 213812_s_at | 0.1718 | 0.1058 | |
| GSE26886 | CAMKK2 | 10645 | 213812_s_at | 0.9804 | 0.0004 | |
| GSE29001 | CAMKK2 | 10645 | 213812_s_at | 0.4707 | 0.0326 | |
| GSE38129 | CAMKK2 | 10645 | 213812_s_at | 0.3572 | 0.0008 | |
| GSE45670 | CAMKK2 | 10645 | 213812_s_at | -0.0289 | 0.8912 | |
| GSE53622 | CAMKK2 | 10645 | 72113 | 0.3644 | 0.0000 | |
| GSE53624 | CAMKK2 | 10645 | 72113 | 0.5098 | 0.0000 | |
| GSE63941 | CAMKK2 | 10645 | 213812_s_at | -0.7317 | 0.1035 | |
| GSE77861 | CAMKK2 | 10645 | 213812_s_at | 0.4463 | 0.0430 | |
| GSE97050 | CAMKK2 | 10645 | A_23_P408830 | 0.0021 | 0.9940 | |
| SRP007169 | CAMKK2 | 10645 | RNAseq | 1.2898 | 0.0027 | |
| SRP008496 | CAMKK2 | 10645 | RNAseq | 1.4852 | 0.0000 | |
| SRP064894 | CAMKK2 | 10645 | RNAseq | 0.2108 | 0.0526 | |
| SRP133303 | CAMKK2 | 10645 | RNAseq | 0.1224 | 0.3248 | |
| SRP159526 | CAMKK2 | 10645 | RNAseq | 0.0087 | 0.9614 | |
| SRP193095 | CAMKK2 | 10645 | RNAseq | 0.3921 | 0.0001 | |
| SRP219564 | CAMKK2 | 10645 | RNAseq | -0.1847 | 0.5265 | |
| TCGA | CAMKK2 | 10645 | RNAseq | -0.0627 | 0.1713 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CAMKK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAMKK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAMKK2 | 10645 | 6 | 3 | 21 | |
| GSE20123 | CAMKK2 | 10645 | 6 | 3 | 21 | |
| GSE43470 | CAMKK2 | 10645 | 2 | 2 | 39 | |
| GSE46452 | CAMKK2 | 10645 | 9 | 1 | 49 | |
| GSE47630 | CAMKK2 | 10645 | 9 | 3 | 28 | |
| GSE54993 | CAMKK2 | 10645 | 0 | 5 | 65 | |
| GSE54994 | CAMKK2 | 10645 | 6 | 7 | 40 | |
| GSE60625 | CAMKK2 | 10645 | 0 | 0 | 11 | |
| GSE74703 | CAMKK2 | 10645 | 2 | 1 | 33 | |
| GSE74704 | CAMKK2 | 10645 | 3 | 2 | 15 | |
| TCGA | CAMKK2 | 10645 | 21 | 10 | 65 |
Total number of gains: 64; Total number of losses: 37; Total Number of normals: 387.
Somatic mutations of CAMKK2:
Generating mutation plots.
Highly correlated genes for CAMKK2:
Showing top 20/1144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAMKK2 | HIRA | 0.799957 | 3 | 0 | 3 |
| CAMKK2 | GPATCH1 | 0.796614 | 3 | 0 | 3 |
| CAMKK2 | TIPRL | 0.785685 | 3 | 0 | 3 |
| CAMKK2 | TP53I11 | 0.779636 | 3 | 0 | 3 |
| CAMKK2 | ZNF362 | 0.777183 | 4 | 0 | 4 |
| CAMKK2 | SLC39A1 | 0.7664 | 4 | 0 | 4 |
| CAMKK2 | NAF1 | 0.765714 | 3 | 0 | 3 |
| CAMKK2 | NR2F2 | 0.756118 | 3 | 0 | 3 |
| CAMKK2 | RCBTB1 | 0.752868 | 3 | 0 | 3 |
| CAMKK2 | HMBOX1 | 0.75044 | 3 | 0 | 3 |
| CAMKK2 | LRP6 | 0.749323 | 3 | 0 | 3 |
| CAMKK2 | NSUN3 | 0.748411 | 3 | 0 | 3 |
| CAMKK2 | GCSH | 0.732057 | 3 | 0 | 3 |
| CAMKK2 | PKIG | 0.731868 | 3 | 0 | 3 |
| CAMKK2 | NAPB | 0.726847 | 3 | 0 | 3 |
| CAMKK2 | TMEM237 | 0.724889 | 3 | 0 | 3 |
| CAMKK2 | SLC39A3 | 0.722959 | 4 | 0 | 3 |
| CAMKK2 | AKAP8 | 0.721891 | 3 | 0 | 3 |
| CAMKK2 | UTP23 | 0.721853 | 5 | 0 | 4 |
| CAMKK2 | KATNA1 | 0.72162 | 3 | 0 | 3 |
For details and further investigation, click here
