| Full name: FANCD2 and FANCI associated nuclease 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q13.3 | ||
| Entrez ID: 22909 | HGNC ID: HGNC:29170 | Ensembl Gene: ENSG00000198690 | OMIM ID: 613534 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FAN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FAN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAN1 | 22909 | 203678_at | 0.1433 | 0.8083 | |
| GSE20347 | FAN1 | 22909 | 203678_at | 0.5710 | 0.0000 | |
| GSE23400 | FAN1 | 22909 | 203678_at | 0.2459 | 0.0000 | |
| GSE26886 | FAN1 | 22909 | 203678_at | 0.2664 | 0.1579 | |
| GSE29001 | FAN1 | 22909 | 203678_at | 0.5367 | 0.0127 | |
| GSE38129 | FAN1 | 22909 | 203678_at | 0.2197 | 0.1104 | |
| GSE45670 | FAN1 | 22909 | 203678_at | 0.0756 | 0.5902 | |
| GSE63941 | FAN1 | 22909 | 203678_at | -0.3916 | 0.2671 | |
| GSE77861 | FAN1 | 22909 | 239289_x_at | 0.0122 | 0.9738 | |
| GSE97050 | FAN1 | 22909 | A_23_P377888 | -0.4298 | 0.1382 | |
| SRP007169 | FAN1 | 22909 | RNAseq | 0.7222 | 0.0711 | |
| SRP008496 | FAN1 | 22909 | RNAseq | 0.6767 | 0.0121 | |
| SRP064894 | FAN1 | 22909 | RNAseq | 0.0948 | 0.5602 | |
| SRP133303 | FAN1 | 22909 | RNAseq | -0.0094 | 0.9509 | |
| SRP159526 | FAN1 | 22909 | RNAseq | 0.3525 | 0.1607 | |
| SRP193095 | FAN1 | 22909 | RNAseq | 0.1158 | 0.2404 | |
| SRP219564 | FAN1 | 22909 | RNAseq | -0.1818 | 0.4973 |
Upregulated datasets: 0; Downregulated datasets: 0.
Copy number change of FAN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAN1 | 22909 | 2 | 7 | 21 | |
| GSE20123 | FAN1 | 22909 | 2 | 7 | 21 | |
| GSE43470 | FAN1 | 22909 | 4 | 4 | 35 | |
| GSE46452 | FAN1 | 22909 | 3 | 7 | 49 | |
| GSE47630 | FAN1 | 22909 | 8 | 11 | 21 | |
| GSE54993 | FAN1 | 22909 | 4 | 6 | 60 | |
| GSE54994 | FAN1 | 22909 | 6 | 7 | 40 | |
| GSE60625 | FAN1 | 22909 | 4 | 0 | 7 | |
| GSE74703 | FAN1 | 22909 | 4 | 3 | 29 | |
| GSE74704 | FAN1 | 22909 | 1 | 6 | 13 | |
| TCGA | FAN1 | 22909 | 16 | 16 | 64 |
Total number of gains: 54; Total number of losses: 74; Total Number of normals: 360.
Somatic mutations of FAN1:
Generating mutation plots.
Highly correlated genes for FAN1:
Showing top 20/398 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAN1 | KLHL15 | 0.838485 | 3 | 0 | 3 |
| FAN1 | LRP6 | 0.788511 | 3 | 0 | 3 |
| FAN1 | MRPL34 | 0.784437 | 3 | 0 | 3 |
| FAN1 | ZBTB44 | 0.780559 | 3 | 0 | 3 |
| FAN1 | PCGF6 | 0.771063 | 4 | 0 | 4 |
| FAN1 | FAM20B | 0.760705 | 3 | 0 | 3 |
| FAN1 | GNPTAB | 0.760119 | 3 | 0 | 3 |
| FAN1 | MTMR12 | 0.756249 | 3 | 0 | 3 |
| FAN1 | EPC2 | 0.747433 | 3 | 0 | 3 |
| FAN1 | KIF5B | 0.746002 | 3 | 0 | 3 |
| FAN1 | SCML1 | 0.745363 | 3 | 0 | 3 |
| FAN1 | ZNF25 | 0.744357 | 4 | 0 | 3 |
| FAN1 | KANSL3 | 0.733535 | 3 | 0 | 3 |
| FAN1 | LARP4 | 0.730584 | 3 | 0 | 3 |
| FAN1 | SGMS1 | 0.73051 | 3 | 0 | 3 |
| FAN1 | MTRF1L | 0.726936 | 3 | 0 | 3 |
| FAN1 | ZNF641 | 0.725245 | 3 | 0 | 3 |
| FAN1 | UNC5CL | 0.725019 | 3 | 0 | 3 |
| FAN1 | B3GALNT2 | 0.72095 | 3 | 0 | 3 |
| FAN1 | MPPED2 | 0.718125 | 4 | 0 | 3 |
For details and further investigation, click here
