| Full name: mediator complex subunit 17 | Alias Symbol: CRSP77|TRAP80|DRIP80|SRB4 | ||
| Type: protein-coding gene | Cytoband: 11q21 | ||
| Entrez ID: 9440 | HGNC ID: HGNC:2375 | Ensembl Gene: ENSG00000042429 | OMIM ID: 603810 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MED17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED17 | 9440 | 221517_s_at | 0.2495 | 0.4447 | |
| GSE20347 | MED17 | 9440 | 221517_s_at | 0.5728 | 0.0290 | |
| GSE23400 | MED17 | 9440 | 221517_s_at | 0.5601 | 0.0000 | |
| GSE26886 | MED17 | 9440 | 221517_s_at | -0.3050 | 0.3876 | |
| GSE29001 | MED17 | 9440 | 221517_s_at | 0.3702 | 0.1880 | |
| GSE38129 | MED17 | 9440 | 221517_s_at | 0.5260 | 0.0010 | |
| GSE45670 | MED17 | 9440 | 221517_s_at | 0.2471 | 0.1370 | |
| GSE53622 | MED17 | 9440 | 36009 | -0.3250 | 0.0000 | |
| GSE53624 | MED17 | 9440 | 36009 | -0.1956 | 0.0974 | |
| GSE63941 | MED17 | 9440 | 221517_s_at | 0.0133 | 0.9774 | |
| GSE77861 | MED17 | 9440 | 221517_s_at | 0.4921 | 0.1475 | |
| GSE97050 | MED17 | 9440 | A_24_P218587 | -0.0865 | 0.6706 | |
| SRP007169 | MED17 | 9440 | RNAseq | 0.5037 | 0.2245 | |
| SRP008496 | MED17 | 9440 | RNAseq | 0.5355 | 0.0241 | |
| SRP064894 | MED17 | 9440 | RNAseq | 0.1375 | 0.4173 | |
| SRP133303 | MED17 | 9440 | RNAseq | 0.0169 | 0.8599 | |
| SRP159526 | MED17 | 9440 | RNAseq | 0.0281 | 0.9306 | |
| SRP193095 | MED17 | 9440 | RNAseq | -0.2898 | 0.0001 | |
| SRP219564 | MED17 | 9440 | RNAseq | -0.1738 | 0.3863 | |
| TCGA | MED17 | 9440 | RNAseq | 0.0099 | 0.8557 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MED17 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED17 | 9440 | 3 | 10 | 17 | |
| GSE20123 | MED17 | 9440 | 3 | 10 | 17 | |
| GSE43470 | MED17 | 9440 | 2 | 5 | 36 | |
| GSE46452 | MED17 | 9440 | 5 | 24 | 30 | |
| GSE47630 | MED17 | 9440 | 2 | 19 | 19 | |
| GSE54993 | MED17 | 9440 | 8 | 2 | 60 | |
| GSE54994 | MED17 | 9440 | 5 | 19 | 29 | |
| GSE60625 | MED17 | 9440 | 0 | 3 | 8 | |
| GSE74703 | MED17 | 9440 | 1 | 4 | 31 | |
| GSE74704 | MED17 | 9440 | 3 | 6 | 11 | |
| TCGA | MED17 | 9440 | 11 | 42 | 43 |
Total number of gains: 43; Total number of losses: 144; Total Number of normals: 301.
Somatic mutations of MED17:
Generating mutation plots.
Highly correlated genes for MED17:
Showing top 20/638 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED17 | TADA1 | 0.76942 | 3 | 0 | 3 |
| MED17 | HIBADH | 0.757247 | 3 | 0 | 3 |
| MED17 | LRP6 | 0.750356 | 3 | 0 | 3 |
| MED17 | RUNDC1 | 0.745961 | 3 | 0 | 3 |
| MED17 | MRPL32 | 0.72912 | 3 | 0 | 3 |
| MED17 | KDM5A | 0.726703 | 3 | 0 | 3 |
| MED17 | SFT2D3 | 0.72406 | 3 | 0 | 3 |
| MED17 | MED22 | 0.72368 | 3 | 0 | 3 |
| MED17 | NDUFA9 | 0.720793 | 4 | 0 | 4 |
| MED17 | DPY19L2 | 0.71988 | 3 | 0 | 3 |
| MED17 | ZNF627 | 0.719377 | 3 | 0 | 3 |
| MED17 | FBXO30 | 0.712583 | 4 | 0 | 4 |
| MED17 | ZCCHC14 | 0.711976 | 3 | 0 | 3 |
| MED17 | AP3S2 | 0.711536 | 3 | 0 | 3 |
| MED17 | KPNA5 | 0.706143 | 3 | 0 | 3 |
| MED17 | BOLA3 | 0.706124 | 3 | 0 | 3 |
| MED17 | BIVM | 0.704389 | 4 | 0 | 3 |
| MED17 | COQ10B | 0.704209 | 3 | 0 | 3 |
| MED17 | MYC | 0.703837 | 5 | 0 | 5 |
| MED17 | PPP1R10 | 0.702542 | 5 | 0 | 4 |
For details and further investigation, click here
