| Full name: leucine rich repeat containing 3 | Alias Symbol: DKFZP434C128 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 81543 | HGNC ID: HGNC:14965 | Ensembl Gene: ENSG00000160233 | OMIM ID: 617620 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC3 | 81543 | 221017_s_at | -0.1710 | 0.5391 | |
| GSE20347 | LRRC3 | 81543 | 221017_s_at | -0.0365 | 0.6790 | |
| GSE23400 | LRRC3 | 81543 | 221017_s_at | -0.0802 | 0.0164 | |
| GSE26886 | LRRC3 | 81543 | 221017_s_at | 0.1638 | 0.2262 | |
| GSE29001 | LRRC3 | 81543 | 221017_s_at | -0.1024 | 0.4686 | |
| GSE38129 | LRRC3 | 81543 | 221017_s_at | -0.1105 | 0.2205 | |
| GSE45670 | LRRC3 | 81543 | 221017_s_at | -0.0705 | 0.4444 | |
| GSE53622 | LRRC3 | 81543 | 47586 | 0.1166 | 0.2042 | |
| GSE53624 | LRRC3 | 81543 | 33994 | 0.4745 | 0.0000 | |
| GSE63941 | LRRC3 | 81543 | 221017_s_at | 0.2442 | 0.2021 | |
| GSE77861 | LRRC3 | 81543 | 221017_s_at | -0.1627 | 0.1944 | |
| GSE97050 | LRRC3 | 81543 | A_33_P3263232 | -0.1541 | 0.5846 | |
| SRP064894 | LRRC3 | 81543 | RNAseq | 0.9816 | 0.0003 | |
| SRP133303 | LRRC3 | 81543 | RNAseq | 0.2390 | 0.2425 | |
| SRP159526 | LRRC3 | 81543 | RNAseq | 0.4819 | 0.2760 | |
| SRP193095 | LRRC3 | 81543 | RNAseq | 0.0448 | 0.8691 | |
| SRP219564 | LRRC3 | 81543 | RNAseq | 0.6837 | 0.0873 | |
| TCGA | LRRC3 | 81543 | RNAseq | -0.1926 | 0.2377 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LRRC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC3 | 81543 | 2 | 8 | 20 | |
| GSE20123 | LRRC3 | 81543 | 2 | 8 | 20 | |
| GSE43470 | LRRC3 | 81543 | 0 | 13 | 30 | |
| GSE46452 | LRRC3 | 81543 | 1 | 21 | 37 | |
| GSE47630 | LRRC3 | 81543 | 6 | 17 | 17 | |
| GSE54993 | LRRC3 | 81543 | 8 | 1 | 61 | |
| GSE54994 | LRRC3 | 81543 | 4 | 8 | 41 | |
| GSE60625 | LRRC3 | 81543 | 0 | 0 | 11 | |
| GSE74703 | LRRC3 | 81543 | 0 | 10 | 26 | |
| GSE74704 | LRRC3 | 81543 | 1 | 4 | 15 | |
| TCGA | LRRC3 | 81543 | 9 | 38 | 49 |
Total number of gains: 33; Total number of losses: 128; Total Number of normals: 327.
Somatic mutations of LRRC3:
Generating mutation plots.
Highly correlated genes for LRRC3:
Showing top 20/899 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC3 | ZCCHC18 | 0.77037 | 3 | 0 | 3 |
| LRRC3 | SEMA5B | 0.757627 | 3 | 0 | 3 |
| LRRC3 | C10orf90 | 0.749351 | 4 | 0 | 4 |
| LRRC3 | PGC | 0.727495 | 3 | 0 | 3 |
| LRRC3 | YY2 | 0.72189 | 3 | 0 | 3 |
| LRRC3 | JAKMIP3 | 0.718235 | 3 | 0 | 3 |
| LRRC3 | NHLRC4 | 0.717063 | 4 | 0 | 3 |
| LRRC3 | BBC3 | 0.716319 | 3 | 0 | 3 |
| LRRC3 | RNF123 | 0.712972 | 3 | 0 | 3 |
| LRRC3 | OR2T1 | 0.712353 | 3 | 0 | 3 |
| LRRC3 | ZNF763 | 0.711994 | 3 | 0 | 3 |
| LRRC3 | HK3 | 0.711914 | 4 | 0 | 4 |
| LRRC3 | PAX6 | 0.711162 | 3 | 0 | 3 |
| LRRC3 | PSTPIP1 | 0.709241 | 3 | 0 | 3 |
| LRRC3 | SUN2 | 0.706476 | 4 | 0 | 3 |
| LRRC3 | FUZ | 0.704981 | 3 | 0 | 3 |
| LRRC3 | DCST1 | 0.69855 | 3 | 0 | 3 |
| LRRC3 | SLC22A31 | 0.698146 | 4 | 0 | 4 |
| LRRC3 | MFSD6L | 0.695851 | 3 | 0 | 3 |
| LRRC3 | OR2D2 | 0.69459 | 3 | 0 | 3 |
For details and further investigation, click here
