LRRC57

 

Full name: leucine rich repeat containing 57 Alias Symbol: FLJ36812
Type: protein-coding gene Cytoband: 15q15.2
Entrez ID: 255252 HGNC ID: HGNC:26719 Ensembl Gene: ENSG00000180979 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of LRRC57:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LRRC57 255252 229232_at -0.0790 0.9144
GSE26886 LRRC57 255252 229232_at 1.2159 0.0000
GSE45670 LRRC57 255252 229232_at 0.2365 0.1267
GSE53622 LRRC57 255252 40426 0.2796 0.0073
GSE53624 LRRC57 255252 40426 0.3903 0.0077
GSE63941 LRRC57 255252 229232_at 0.0719 0.8536
GSE77861 LRRC57 255252 229232_at 0.3563 0.3406
SRP007169 LRRC57 255252 RNAseq 0.1064 0.7806
SRP008496 LRRC57 255252 RNAseq -0.0632 0.7656
SRP064894 LRRC57 255252 RNAseq 0.3028 0.0021
SRP133303 LRRC57 255252 RNAseq 0.2307 0.0402
SRP159526 LRRC57 255252 RNAseq 0.2248 0.3173
SRP193095 LRRC57 255252 RNAseq 0.1167 0.1013
SRP219564 LRRC57 255252 RNAseq -0.2469 0.3576
TCGA LRRC57 255252 RNAseq 0.0533 0.3626

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by LRRC57 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LRRC57:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LRRC57 255252 4 5 21
GSE20123 LRRC57 255252 4 6 20
GSE43470 LRRC57 255252 4 5 34
GSE46452 LRRC57 255252 3 7 49
GSE47630 LRRC57 255252 8 10 22
GSE54993 LRRC57 255252 4 6 60
GSE54994 LRRC57 255252 5 7 41
GSE60625 LRRC57 255252 4 0 7
GSE74703 LRRC57 255252 4 4 28
GSE74704 LRRC57 255252 3 3 14
TCGA LRRC57 255252 11 17 68

Total number of gains: 54; Total number of losses: 70; Total Number of normals: 364.  

 

Somatic mutations of LRRC57:

 

Generating mutation plots.

 

Highly correlated genes for LRRC57:

 

Showing top 20/104 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LRRC57TTC270.689196303
LRRC57FKBP90.683379303
LRRC57C15orf400.679618303
LRRC57AVEN0.678745404
LRRC57ZNF1460.674404303
LRRC57CTSC0.672607303
LRRC57PSMD10.672237303
LRRC57KBTBD20.668625404
LRRC57CARD100.661967303
LRRC57RRN30.651137303
LRRC57NGRN0.646737505
LRRC57LIG40.645089303
LRRC57PLEKHA10.63564403
LRRC57MZT10.629953504
LRRC57MFAP10.628812606
LRRC57SLC37A30.628708403
LRRC57HERPUD20.628693403
LRRC57GOLIM40.623447403
LRRC57ANXA70.622416303
LRRC57DYNC2LI10.621041303

For details and further investigation, click here