| Full name: DNA ligase 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q33.3 | ||
| Entrez ID: 3981 | HGNC ID: HGNC:6601 | Ensembl Gene: ENSG00000174405 | OMIM ID: 601837 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LIG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIG4 | 3981 | 227766_at | 0.0793 | 0.8846 | |
| GSE20347 | LIG4 | 3981 | 206235_at | 0.2664 | 0.2751 | |
| GSE23400 | LIG4 | 3981 | 206235_at | 0.0411 | 0.2510 | |
| GSE26886 | LIG4 | 3981 | 227766_at | 1.0043 | 0.0005 | |
| GSE29001 | LIG4 | 3981 | 206235_at | 0.0518 | 0.7068 | |
| GSE38129 | LIG4 | 3981 | 206235_at | 0.2203 | 0.1850 | |
| GSE45670 | LIG4 | 3981 | 227766_at | 0.3600 | 0.0684 | |
| GSE53622 | LIG4 | 3981 | 46260 | -0.1127 | 0.5845 | |
| GSE53624 | LIG4 | 3981 | 46260 | -0.1923 | 0.1630 | |
| GSE63941 | LIG4 | 3981 | 227766_at | -0.5537 | 0.4817 | |
| GSE77861 | LIG4 | 3981 | 206235_at | -0.0305 | 0.8502 | |
| SRP007169 | LIG4 | 3981 | RNAseq | 1.0688 | 0.0461 | |
| SRP008496 | LIG4 | 3981 | RNAseq | 1.1103 | 0.0113 | |
| SRP064894 | LIG4 | 3981 | RNAseq | 0.2281 | 0.4700 | |
| SRP133303 | LIG4 | 3981 | RNAseq | 0.3836 | 0.0698 | |
| SRP159526 | LIG4 | 3981 | RNAseq | -0.3443 | 0.3804 | |
| SRP193095 | LIG4 | 3981 | RNAseq | -0.0422 | 0.7919 | |
| SRP219564 | LIG4 | 3981 | RNAseq | -0.0808 | 0.7991 | |
| TCGA | LIG4 | 3981 | RNAseq | -0.1751 | 0.0155 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LIG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIG4 | 3981 | 6 | 11 | 13 | |
| GSE20123 | LIG4 | 3981 | 6 | 10 | 14 | |
| GSE43470 | LIG4 | 3981 | 4 | 12 | 27 | |
| GSE46452 | LIG4 | 3981 | 1 | 31 | 27 | |
| GSE47630 | LIG4 | 3981 | 3 | 26 | 11 | |
| GSE54993 | LIG4 | 3981 | 11 | 4 | 55 | |
| GSE54994 | LIG4 | 3981 | 8 | 8 | 37 | |
| GSE60625 | LIG4 | 3981 | 0 | 3 | 8 | |
| GSE74703 | LIG4 | 3981 | 3 | 9 | 24 | |
| GSE74704 | LIG4 | 3981 | 4 | 10 | 6 | |
| TCGA | LIG4 | 3981 | 18 | 33 | 45 |
Total number of gains: 64; Total number of losses: 157; Total Number of normals: 267.
Somatic mutations of LIG4:
Generating mutation plots.
Highly correlated genes for LIG4:
Showing top 20/44 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIG4 | GDF15 | 0.650391 | 3 | 0 | 3 |
| LIG4 | LRRC57 | 0.645089 | 3 | 0 | 3 |
| LIG4 | PDCD2 | 0.624316 | 3 | 0 | 3 |
| LIG4 | CWC22 | 0.623458 | 3 | 0 | 3 |
| LIG4 | COCH | 0.623227 | 4 | 0 | 3 |
| LIG4 | TMEM38B | 0.616566 | 4 | 0 | 4 |
| LIG4 | UPF3A | 0.6148 | 5 | 0 | 4 |
| LIG4 | VOPP1 | 0.606826 | 3 | 0 | 3 |
| LIG4 | ZNF621 | 0.598043 | 3 | 0 | 3 |
| LIG4 | HINT1 | 0.597011 | 3 | 0 | 3 |
| LIG4 | CUL4A | 0.595963 | 8 | 0 | 6 |
| LIG4 | NELFB | 0.594538 | 3 | 0 | 3 |
| LIG4 | ABHD13 | 0.593215 | 6 | 0 | 5 |
| LIG4 | IRX2 | 0.592958 | 3 | 0 | 3 |
| LIG4 | ZNF700 | 0.589595 | 4 | 0 | 3 |
| LIG4 | MRPS17 | 0.584074 | 4 | 0 | 3 |
| LIG4 | MCOLN3 | 0.581712 | 5 | 0 | 4 |
| LIG4 | NPHP3 | 0.578799 | 3 | 0 | 3 |
| LIG4 | GNB5 | 0.575507 | 4 | 0 | 3 |
| LIG4 | SENP6 | 0.574295 | 5 | 0 | 3 |
For details and further investigation, click here
