| Full name: RRN3 homolog, RNA polymerase I transcription factor | Alias Symbol: DKFZp566E104|TIF-IA | ||
| Type: protein-coding gene | Cytoband: 16p13.11 | ||
| Entrez ID: 54700 | HGNC ID: HGNC:30346 | Ensembl Gene: ENSG00000085721 | OMIM ID: 605121 |
| Drug and gene relationship at DGIdb | |||
Expression of RRN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RRN3 | 54700 | 222204_s_at | 0.0984 | 0.9093 | |
| GSE20347 | RRN3 | 54700 | 222204_s_at | 0.3787 | 0.0014 | |
| GSE23400 | RRN3 | 54700 | 222204_s_at | 0.5771 | 0.0000 | |
| GSE26886 | RRN3 | 54700 | 222204_s_at | 0.2309 | 0.3564 | |
| GSE29001 | RRN3 | 54700 | 222204_s_at | 0.6861 | 0.0174 | |
| GSE38129 | RRN3 | 54700 | 222204_s_at | 0.4570 | 0.0000 | |
| GSE45670 | RRN3 | 54700 | 222204_s_at | 0.2205 | 0.1259 | |
| GSE53622 | RRN3 | 54700 | 32527 | 0.2426 | 0.0000 | |
| GSE53624 | RRN3 | 54700 | 32527 | 0.3061 | 0.0000 | |
| GSE63941 | RRN3 | 54700 | 222204_s_at | -0.2513 | 0.4950 | |
| GSE77861 | RRN3 | 54700 | 222204_s_at | 0.4078 | 0.1303 | |
| GSE97050 | RRN3 | 54700 | A_24_P590560 | 0.0451 | 0.8723 | |
| SRP007169 | RRN3 | 54700 | RNAseq | 1.2494 | 0.0007 | |
| SRP008496 | RRN3 | 54700 | RNAseq | 1.4809 | 0.0000 | |
| SRP064894 | RRN3 | 54700 | RNAseq | 0.0969 | 0.6006 | |
| SRP133303 | RRN3 | 54700 | RNAseq | 0.6326 | 0.0002 | |
| SRP159526 | RRN3 | 54700 | RNAseq | 0.3170 | 0.3815 | |
| SRP193095 | RRN3 | 54700 | RNAseq | 0.3278 | 0.0030 | |
| SRP219564 | RRN3 | 54700 | RNAseq | 0.1302 | 0.5961 | |
| TCGA | RRN3 | 54700 | RNAseq | 0.0091 | 0.8469 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RRN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RRN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RRN3 | 54700 | 5 | 4 | 21 | |
| GSE20123 | RRN3 | 54700 | 5 | 3 | 22 | |
| GSE43470 | RRN3 | 54700 | 3 | 3 | 37 | |
| GSE46452 | RRN3 | 54700 | 38 | 1 | 20 | |
| GSE47630 | RRN3 | 54700 | 11 | 6 | 23 | |
| GSE54993 | RRN3 | 54700 | 3 | 5 | 62 | |
| GSE54994 | RRN3 | 54700 | 4 | 10 | 39 | |
| GSE60625 | RRN3 | 54700 | 4 | 1 | 6 | |
| GSE74703 | RRN3 | 54700 | 3 | 2 | 31 | |
| GSE74704 | RRN3 | 54700 | 2 | 1 | 17 | |
| TCGA | RRN3 | 54700 | 20 | 12 | 64 |
Total number of gains: 98; Total number of losses: 48; Total Number of normals: 342.
Somatic mutations of RRN3:
Generating mutation plots.
Highly correlated genes for RRN3:
Showing top 20/1063 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RRN3 | BBS4 | 0.800306 | 3 | 0 | 3 |
| RRN3 | C16orf72 | 0.780996 | 3 | 0 | 3 |
| RRN3 | PLEKHM3 | 0.775078 | 4 | 0 | 4 |
| RRN3 | SMU1 | 0.758481 | 3 | 0 | 3 |
| RRN3 | TTC26 | 0.747632 | 5 | 0 | 4 |
| RRN3 | DNTTIP1 | 0.747299 | 3 | 0 | 3 |
| RRN3 | BRAT1 | 0.737491 | 3 | 0 | 3 |
| RRN3 | CUL2 | 0.733768 | 4 | 0 | 4 |
| RRN3 | LMBR1 | 0.730332 | 3 | 0 | 3 |
| RRN3 | SLC35A5 | 0.723031 | 3 | 0 | 3 |
| RRN3 | BCS1L | 0.722748 | 4 | 0 | 3 |
| RRN3 | LZIC | 0.72023 | 3 | 0 | 3 |
| RRN3 | UBR3 | 0.718004 | 3 | 0 | 3 |
| RRN3 | ZXDA | 0.712444 | 3 | 0 | 3 |
| RRN3 | TADA2A | 0.71195 | 3 | 0 | 3 |
| RRN3 | C21orf91 | 0.711899 | 5 | 0 | 5 |
| RRN3 | CDC42SE2 | 0.710538 | 3 | 0 | 3 |
| RRN3 | TMEM38B | 0.709648 | 5 | 0 | 5 |
| RRN3 | PPP1R8 | 0.709159 | 5 | 0 | 4 |
| RRN3 | ZNF32 | 0.705305 | 3 | 0 | 3 |
For details and further investigation, click here
