CTSC

 

Full name: cathepsin C Alias Symbol: DPP1
Type: protein-coding gene Cytoband: 11q14.2
Entrez ID: 1075 HGNC ID: HGNC:2528 Ensembl Gene: ENSG00000109861 OMIM ID: 602365
Drug and gene relationship at DGIdb

 

CTSC involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of CTSC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CTSC 1075 201487_at 0.8402 0.2733
GSE20347 CTSC 1075 201487_at 0.9189 0.0201
GSE23400 CTSC 1075 201487_at 1.3706 0.0000
GSE26886 CTSC 1075 201487_at 1.1074 0.0011
GSE29001 CTSC 1075 201487_at 0.9096 0.0421
GSE38129 CTSC 1075 201487_at 1.2343 0.0000
GSE45670 CTSC 1075 201487_at 1.3237 0.0000
GSE53622 CTSC 1075 54220 1.5257 0.0000
GSE53624 CTSC 1075 54220 1.4649 0.0000
GSE63941 CTSC 1075 225647_s_at -0.9712 0.2981
GSE77861 CTSC 1075 201487_at 1.2456 0.0165
GSE97050 CTSC 1075 A_23_P1552 1.8581 0.0762
SRP007169 CTSC 1075 RNAseq 2.6491 0.0000
SRP008496 CTSC 1075 RNAseq 2.4429 0.0000
SRP064894 CTSC 1075 RNAseq 1.5781 0.0000
SRP133303 CTSC 1075 RNAseq 1.3069 0.0000
SRP159526 CTSC 1075 RNAseq 1.8770 0.0074
SRP193095 CTSC 1075 RNAseq 1.0579 0.0000
SRP219564 CTSC 1075 RNAseq 2.3683 0.0002
TCGA CTSC 1075 RNAseq 0.4771 0.0000

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by CTSC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTSC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTSC 1075 3 10 17
GSE20123 CTSC 1075 3 10 17
GSE43470 CTSC 1075 3 4 36
GSE46452 CTSC 1075 6 23 30
GSE47630 CTSC 1075 2 19 19
GSE54993 CTSC 1075 8 2 60
GSE54994 CTSC 1075 5 19 29
GSE60625 CTSC 1075 0 4 7
GSE74703 CTSC 1075 2 3 31
GSE74704 CTSC 1075 3 6 11
TCGA CTSC 1075 15 38 43

Total number of gains: 50; Total number of losses: 138; Total Number of normals: 300.  

 

Somatic mutations of CTSC:

 

Generating mutation plots.

 

Highly correlated genes for CTSC:

 

Showing top 20/1148 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTSCDCBLD10.766498707
CTSCFANCD20.70611403
CTSCADAMTS20.698308504
CTSCEME10.696188505
CTSCTPM30.695539606
CTSCXPO50.691003707
CTSCMMP120.68586611011
CTSCZNF4690.684919606
CTSCSPRR2G0.684656303
CTSCWDR660.68097707
CTSCNOP560.675889303
CTSCLRRC570.672607303
CTSCKIF140.67257111010
CTSCMELK0.67152510010
CTSCMTFR20.670126606
CTSCCDCA50.669543606
CTSCFAM89A0.666535303
CTSCNUF20.665448707
CTSCFANCI0.6647511009
CTSCUHRF10.663688707

For details and further investigation, click here