| Full name: leucine rich repeat containing 6 | Alias Symbol: TSLRP|LRTP|CILD19 | ||
| Type: protein-coding gene | Cytoband: 8q24.22 | ||
| Entrez ID: 23639 | HGNC ID: HGNC:16725 | Ensembl Gene: ENSG00000129295 | OMIM ID: 614930 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC6 | 23639 | 206483_at | 0.5329 | 0.5751 | |
| GSE20347 | LRRC6 | 23639 | 206483_at | -0.1981 | 0.1339 | |
| GSE23400 | LRRC6 | 23639 | 206483_at | -0.1266 | 0.0028 | |
| GSE26886 | LRRC6 | 23639 | 206483_at | 0.0376 | 0.9224 | |
| GSE29001 | LRRC6 | 23639 | 206483_at | -0.2296 | 0.4243 | |
| GSE38129 | LRRC6 | 23639 | 206483_at | -0.1921 | 0.1492 | |
| GSE45670 | LRRC6 | 23639 | 206483_at | 0.1138 | 0.7360 | |
| GSE53622 | LRRC6 | 23639 | 12524 | -0.1032 | 0.5138 | |
| GSE53624 | LRRC6 | 23639 | 12524 | -0.1011 | 0.3425 | |
| GSE63941 | LRRC6 | 23639 | 206483_at | -1.0211 | 0.0338 | |
| GSE77861 | LRRC6 | 23639 | 206483_at | -0.2484 | 0.0842 | |
| GSE97050 | LRRC6 | 23639 | A_23_P112004 | -0.0449 | 0.8626 | |
| SRP064894 | LRRC6 | 23639 | RNAseq | 0.4047 | 0.1760 | |
| SRP133303 | LRRC6 | 23639 | RNAseq | -0.3748 | 0.1502 | |
| SRP159526 | LRRC6 | 23639 | RNAseq | 0.1685 | 0.7399 | |
| SRP193095 | LRRC6 | 23639 | RNAseq | 0.1567 | 0.4372 | |
| SRP219564 | LRRC6 | 23639 | RNAseq | 0.0357 | 0.9427 | |
| TCGA | LRRC6 | 23639 | RNAseq | 0.0442 | 0.9119 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LRRC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC6 | 23639 | 18 | 0 | 12 | |
| GSE20123 | LRRC6 | 23639 | 18 | 0 | 12 | |
| GSE43470 | LRRC6 | 23639 | 23 | 1 | 19 | |
| GSE46452 | LRRC6 | 23639 | 27 | 0 | 32 | |
| GSE47630 | LRRC6 | 23639 | 24 | 0 | 16 | |
| GSE54993 | LRRC6 | 23639 | 0 | 24 | 46 | |
| GSE54994 | LRRC6 | 23639 | 39 | 1 | 13 | |
| GSE60625 | LRRC6 | 23639 | 0 | 7 | 4 | |
| GSE74703 | LRRC6 | 23639 | 20 | 0 | 16 | |
| GSE74704 | LRRC6 | 23639 | 12 | 0 | 8 | |
| TCGA | LRRC6 | 23639 | 66 | 2 | 28 |
Total number of gains: 247; Total number of losses: 35; Total Number of normals: 206.
Somatic mutations of LRRC6:
Generating mutation plots.
Highly correlated genes for LRRC6:
Showing top 20/103 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC6 | HSD11B1L | 0.706427 | 3 | 0 | 3 |
| LRRC6 | FAM110B | 0.693451 | 4 | 0 | 4 |
| LRRC6 | ZCCHC18 | 0.680643 | 4 | 0 | 4 |
| LRRC6 | OLFM4 | 0.672824 | 3 | 0 | 3 |
| LRRC6 | PDK4 | 0.664033 | 3 | 0 | 3 |
| LRRC6 | RETN | 0.657227 | 3 | 0 | 3 |
| LRRC6 | TAF1 | 0.629725 | 3 | 0 | 3 |
| LRRC6 | FABP6 | 0.625741 | 3 | 0 | 3 |
| LRRC6 | OSBPL7 | 0.62097 | 3 | 0 | 3 |
| LRRC6 | MAML3 | 0.619652 | 4 | 0 | 3 |
| LRRC6 | NATD1 | 0.618188 | 3 | 0 | 3 |
| LRRC6 | MEP1B | 0.617624 | 3 | 0 | 3 |
| LRRC6 | RAI2 | 0.616479 | 5 | 0 | 4 |
| LRRC6 | SLC30A3 | 0.610594 | 4 | 0 | 3 |
| LRRC6 | ZNF423 | 0.610224 | 3 | 0 | 3 |
| LRRC6 | CSH1 | 0.60655 | 4 | 0 | 3 |
| LRRC6 | ADAM21 | 0.6036 | 4 | 0 | 4 |
| LRRC6 | GPAT2 | 0.602079 | 4 | 0 | 3 |
| LRRC6 | CHD5 | 0.596464 | 4 | 0 | 3 |
| LRRC6 | CYP46A1 | 0.595256 | 5 | 0 | 4 |
For details and further investigation, click here
