TAF1

 

Full name: TATA-box binding protein associated factor 1 Alias Symbol: NSCL2|TAFII250|KAT4|DYT3/TAF1
Type: protein-coding gene Cytoband: Xq13.1
Entrez ID: 6872 HGNC ID: HGNC:11535 Ensembl Gene: ENSG00000147133 OMIM ID: 313650
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 242/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TAF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TAF1 6872 227205_at 0.0876 0.8657
GSE20347 TAF1 6872 216711_s_at -0.1141 0.3328
GSE23400 TAF1 6872 216955_at -0.0629 0.0752
GSE26886 TAF1 6872 227205_at 0.9319 0.0016
GSE29001 TAF1 6872 216955_at -0.1928 0.1608
GSE38129 TAF1 6872 216711_s_at -0.0705 0.4619
GSE45670 TAF1 6872 227205_at -0.0323 0.8834
GSE53622 TAF1 6872 82932 -0.0180 0.7816
GSE53624 TAF1 6872 82932 0.0507 0.3581
GSE63941 TAF1 6872 227205_at -0.3742 0.3225
GSE77861 TAF1 6872 227205_at 0.2897 0.0241
GSE97050 TAF1 6872 A_32_P192615 -0.2712 0.3750
SRP007169 TAF1 6872 RNAseq 1.2287 0.0015
SRP008496 TAF1 6872 RNAseq 1.0147 0.0006
SRP064894 TAF1 6872 RNAseq 0.1094 0.7080
SRP133303 TAF1 6872 RNAseq 0.0267 0.7947
SRP159526 TAF1 6872 RNAseq 0.2137 0.1572
SRP193095 TAF1 6872 RNAseq 0.2720 0.0146
SRP219564 TAF1 6872 RNAseq 0.1054 0.6871
TCGA TAF1 6872 RNAseq -0.0596 0.2225

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TAF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TAF1:

 

No record found for this gene.

 

Somatic mutations of TAF1:

 

Generating mutation plots.

 

Highly correlated genes for TAF1:

 

Showing top 20/145 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TAF1WDR810.780689303
TAF1RCVRN0.750805303
TAF1FABP30.741779303
TAF1KANSL30.733624404
TAF1SLC22A20.728134303
TAF1LTBP40.721715303
TAF1CNGA30.718091303
TAF1PTPRJ0.712525303
TAF1DVL20.708643403
TAF1RIT20.703511303
TAF1SPATA170.699206303
TAF1NTSR20.699103303
TAF1GRIK30.695105303
TAF1TSC22D10.694105303
TAF1STXBP60.694058403
TAF1INO80D0.689412303
TAF1NOP580.687627303
TAF1XYLT20.679879303
TAF1COL4A60.668483303
TAF1ZMIZ20.668015303

For details and further investigation, click here