| Full name: cytochrome P450 family 46 subfamily A member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q32.2 | ||
| Entrez ID: 10858 | HGNC ID: HGNC:2641 | Ensembl Gene: ENSG00000036530 | OMIM ID: 604087 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP46A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP46A1 | 10858 | 220331_at | 0.2950 | 0.6396 | |
| GSE20347 | CYP46A1 | 10858 | 220331_at | -0.0150 | 0.8653 | |
| GSE23400 | CYP46A1 | 10858 | 220331_at | -0.1062 | 0.0234 | |
| GSE26886 | CYP46A1 | 10858 | 220331_at | 0.0269 | 0.9103 | |
| GSE29001 | CYP46A1 | 10858 | 220331_at | 0.1409 | 0.6768 | |
| GSE38129 | CYP46A1 | 10858 | 220331_at | -0.2214 | 0.0117 | |
| GSE45670 | CYP46A1 | 10858 | 220331_at | -0.0705 | 0.5599 | |
| GSE53622 | CYP46A1 | 10858 | 20044 | 0.0620 | 0.5555 | |
| GSE53624 | CYP46A1 | 10858 | 19614 | 0.5328 | 0.0000 | |
| GSE63941 | CYP46A1 | 10858 | 220331_at | -0.4186 | 0.0160 | |
| GSE77861 | CYP46A1 | 10858 | 220331_at | -0.1853 | 0.2188 | |
| GSE97050 | CYP46A1 | 10858 | A_23_P48784 | -0.0303 | 0.9191 | |
| SRP219564 | CYP46A1 | 10858 | RNAseq | 0.6954 | 0.3854 | |
| TCGA | CYP46A1 | 10858 | RNAseq | -0.5323 | 0.0998 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP46A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP46A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP46A1 | 10858 | 10 | 5 | 15 | |
| GSE20123 | CYP46A1 | 10858 | 10 | 4 | 16 | |
| GSE43470 | CYP46A1 | 10858 | 7 | 4 | 32 | |
| GSE46452 | CYP46A1 | 10858 | 17 | 3 | 39 | |
| GSE47630 | CYP46A1 | 10858 | 11 | 8 | 21 | |
| GSE54993 | CYP46A1 | 10858 | 3 | 8 | 59 | |
| GSE54994 | CYP46A1 | 10858 | 21 | 4 | 28 | |
| GSE60625 | CYP46A1 | 10858 | 0 | 2 | 9 | |
| GSE74703 | CYP46A1 | 10858 | 6 | 3 | 27 | |
| GSE74704 | CYP46A1 | 10858 | 6 | 3 | 11 | |
| TCGA | CYP46A1 | 10858 | 31 | 18 | 47 |
Total number of gains: 122; Total number of losses: 62; Total Number of normals: 304.
Somatic mutations of CYP46A1:
Generating mutation plots.
Highly correlated genes for CYP46A1:
Showing top 20/299 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP46A1 | SIRPD | 0.693111 | 3 | 0 | 3 |
| CYP46A1 | NTNG2 | 0.680523 | 3 | 0 | 3 |
| CYP46A1 | FAM71A | 0.670775 | 4 | 0 | 4 |
| CYP46A1 | OR7A17 | 0.663535 | 3 | 0 | 3 |
| CYP46A1 | GPR26 | 0.653768 | 4 | 0 | 4 |
| CYP46A1 | SERHL2 | 0.646627 | 3 | 0 | 3 |
| CYP46A1 | GPSM3 | 0.641183 | 4 | 0 | 4 |
| CYP46A1 | LINC00907 | 0.640148 | 3 | 0 | 3 |
| CYP46A1 | ASTN2 | 0.639925 | 3 | 0 | 3 |
| CYP46A1 | SATB2-AS1 | 0.637377 | 4 | 0 | 4 |
| CYP46A1 | ZCCHC18 | 0.636209 | 4 | 0 | 4 |
| CYP46A1 | SALL3 | 0.635648 | 3 | 0 | 3 |
| CYP46A1 | ARX | 0.635231 | 4 | 0 | 4 |
| CYP46A1 | PCSK1N | 0.633164 | 5 | 0 | 4 |
| CYP46A1 | DEFB121 | 0.632916 | 4 | 0 | 4 |
| CYP46A1 | TBX21 | 0.623791 | 3 | 0 | 3 |
| CYP46A1 | LCNL1 | 0.622543 | 3 | 0 | 3 |
| CYP46A1 | TEX22 | 0.622442 | 4 | 0 | 3 |
| CYP46A1 | MPO | 0.621887 | 4 | 0 | 3 |
| CYP46A1 | PIWIL1 | 0.618097 | 3 | 0 | 3 |
For details and further investigation, click here
