| Full name: complement C3b/C4b receptor 1 (Knops blood group) | Alias Symbol: CD35|KN | ||
| Type: protein-coding gene | Cytoband: 1q32.2 | ||
| Entrez ID: 1378 | HGNC ID: HGNC:2334 | Ensembl Gene: ENSG00000203710 | OMIM ID: 120620 |
| Drug and gene relationship at DGIdb | |||
CR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05140 | Leishmaniasis | |
| hsa05152 | Tuberculosis |
Expression of CR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CR1 | 1378 | 208488_s_at | -0.0937 | 0.8664 | |
| GSE20347 | CR1 | 1378 | 208488_s_at | 0.0492 | 0.5373 | |
| GSE23400 | CR1 | 1378 | 208488_s_at | -0.0325 | 0.3110 | |
| GSE26886 | CR1 | 1378 | 208488_s_at | 0.0473 | 0.6491 | |
| GSE29001 | CR1 | 1378 | 208488_s_at | -0.0502 | 0.7857 | |
| GSE38129 | CR1 | 1378 | 208488_s_at | -0.0440 | 0.5454 | |
| GSE45670 | CR1 | 1378 | 217484_at | -0.0730 | 0.4710 | |
| GSE53622 | CR1 | 1378 | 10771 | -0.7471 | 0.0002 | |
| GSE53624 | CR1 | 1378 | 10771 | -0.5455 | 0.0013 | |
| GSE63941 | CR1 | 1378 | 208488_s_at | -0.0217 | 0.8942 | |
| GSE77861 | CR1 | 1378 | 208488_s_at | -0.0915 | 0.3380 | |
| GSE97050 | CR1 | 1378 | A_23_P256821 | 0.7599 | 0.2515 | |
| SRP007169 | CR1 | 1378 | RNAseq | 3.6972 | 0.0000 | |
| SRP133303 | CR1 | 1378 | RNAseq | -0.0284 | 0.9443 | |
| SRP159526 | CR1 | 1378 | RNAseq | -0.8735 | 0.3418 | |
| SRP193095 | CR1 | 1378 | RNAseq | 0.8279 | 0.0095 | |
| SRP219564 | CR1 | 1378 | RNAseq | 1.1945 | 0.1353 | |
| TCGA | CR1 | 1378 | RNAseq | -0.8851 | 0.0245 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CR1 | 1378 | 11 | 0 | 19 | |
| GSE20123 | CR1 | 1378 | 11 | 0 | 19 | |
| GSE43470 | CR1 | 1378 | 9 | 0 | 34 | |
| GSE46452 | CR1 | 1378 | 3 | 1 | 55 | |
| GSE47630 | CR1 | 1378 | 14 | 0 | 26 | |
| GSE54993 | CR1 | 1378 | 0 | 6 | 64 | |
| GSE54994 | CR1 | 1378 | 14 | 0 | 39 | |
| GSE60625 | CR1 | 1378 | 0 | 0 | 11 | |
| GSE74703 | CR1 | 1378 | 9 | 0 | 27 | |
| GSE74704 | CR1 | 1378 | 5 | 0 | 15 | |
| TCGA | CR1 | 1378 | 45 | 3 | 48 |
Total number of gains: 121; Total number of losses: 10; Total Number of normals: 357.
Somatic mutations of CR1:
Generating mutation plots.
Highly correlated genes for CR1:
Showing top 20/333 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CR1 | GMFG | 0.773042 | 4 | 0 | 4 |
| CR1 | MPEG1 | 0.744416 | 5 | 0 | 4 |
| CR1 | GIMAP4 | 0.721836 | 4 | 0 | 4 |
| CR1 | ATP8B4 | 0.713756 | 5 | 0 | 4 |
| CR1 | AIF1 | 0.706571 | 4 | 0 | 4 |
| CR1 | C1orf162 | 0.70176 | 4 | 0 | 4 |
| CR1 | ARHGAP15 | 0.697908 | 3 | 0 | 3 |
| CR1 | GAPT | 0.697818 | 4 | 0 | 4 |
| CR1 | IRF8 | 0.694382 | 4 | 0 | 4 |
| CR1 | DAB2 | 0.690342 | 3 | 0 | 3 |
| CR1 | PLCL2 | 0.68603 | 3 | 0 | 3 |
| CR1 | GIMAP2 | 0.684118 | 4 | 0 | 3 |
| CR1 | LTB | 0.681724 | 3 | 0 | 3 |
| CR1 | GPR34 | 0.681297 | 4 | 0 | 3 |
| CR1 | GIMAP6 | 0.679861 | 4 | 0 | 4 |
| CR1 | CYTIP | 0.678386 | 4 | 0 | 4 |
| CR1 | GPR65 | 0.67718 | 4 | 0 | 4 |
| CR1 | RGS18 | 0.672252 | 4 | 0 | 4 |
| CR1 | NAGLU | 0.671817 | 3 | 0 | 3 |
| CR1 | MS4A4A | 0.671702 | 4 | 0 | 4 |
For details and further investigation, click here
