| Full name: glutaredoxin | Alias Symbol: GRX|GRX1 | ||
| Type: protein-coding gene | Cytoband: 5q15 | ||
| Entrez ID: 2745 | HGNC ID: HGNC:4330 | Ensembl Gene: ENSG00000173221 | OMIM ID: 600443 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GLRX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLRX | 2745 | 206662_at | 0.2397 | 0.7878 | |
| GSE20347 | GLRX | 2745 | 206662_at | 0.9005 | 0.0000 | |
| GSE23400 | GLRX | 2745 | 206662_at | 0.5817 | 0.0000 | |
| GSE26886 | GLRX | 2745 | 206662_at | 0.1578 | 0.5874 | |
| GSE29001 | GLRX | 2745 | 206662_at | 0.9699 | 0.0031 | |
| GSE38129 | GLRX | 2745 | 206662_at | 0.4194 | 0.0949 | |
| GSE45670 | GLRX | 2745 | 206662_at | 0.1453 | 0.6733 | |
| GSE53622 | GLRX | 2745 | 128563 | 0.5294 | 0.0000 | |
| GSE53624 | GLRX | 2745 | 128563 | 0.7410 | 0.0000 | |
| GSE63941 | GLRX | 2745 | 206662_at | -3.5331 | 0.0032 | |
| GSE77861 | GLRX | 2745 | 209276_s_at | 0.2387 | 0.0979 | |
| GSE97050 | GLRX | 2745 | A_23_P69908 | 0.6525 | 0.2155 | |
| SRP007169 | GLRX | 2745 | RNAseq | 1.5558 | 0.0183 | |
| SRP008496 | GLRX | 2745 | RNAseq | 0.9554 | 0.0279 | |
| SRP064894 | GLRX | 2745 | RNAseq | 0.2964 | 0.3149 | |
| SRP133303 | GLRX | 2745 | RNAseq | 0.6369 | 0.0087 | |
| SRP159526 | GLRX | 2745 | RNAseq | 0.7648 | 0.0601 | |
| SRP193095 | GLRX | 2745 | RNAseq | -0.0498 | 0.8893 | |
| SRP219564 | GLRX | 2745 | RNAseq | 0.6190 | 0.2147 | |
| TCGA | GLRX | 2745 | RNAseq | -0.2282 | 0.0585 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by GLRX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLRX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLRX | 2745 | 1 | 13 | 16 | |
| GSE20123 | GLRX | 2745 | 1 | 13 | 16 | |
| GSE43470 | GLRX | 2745 | 3 | 9 | 31 | |
| GSE46452 | GLRX | 2745 | 0 | 28 | 31 | |
| GSE47630 | GLRX | 2745 | 0 | 20 | 20 | |
| GSE54993 | GLRX | 2745 | 8 | 1 | 61 | |
| GSE54994 | GLRX | 2745 | 1 | 18 | 34 | |
| GSE60625 | GLRX | 2745 | 0 | 0 | 11 | |
| GSE74703 | GLRX | 2745 | 2 | 7 | 27 | |
| GSE74704 | GLRX | 2745 | 1 | 7 | 12 | |
| TCGA | GLRX | 2745 | 3 | 44 | 49 |
Total number of gains: 20; Total number of losses: 160; Total Number of normals: 308.
Somatic mutations of GLRX:
Generating mutation plots.
Highly correlated genes for GLRX:
Showing top 20/1084 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLRX | ANKRD44 | 0.82211 | 3 | 0 | 3 |
| GLRX | FCGR3A | 0.79467 | 3 | 0 | 3 |
| GLRX | C19orf38 | 0.744838 | 3 | 0 | 3 |
| GLRX | PREX1 | 0.743648 | 4 | 0 | 3 |
| GLRX | SUCNR1 | 0.7431 | 4 | 0 | 4 |
| GLRX | CERKL | 0.741453 | 3 | 0 | 3 |
| GLRX | LRRC8C | 0.722022 | 3 | 0 | 3 |
| GLRX | PDIA5 | 0.716675 | 3 | 0 | 3 |
| GLRX | GNGT2 | 0.715571 | 4 | 0 | 3 |
| GLRX | TK2 | 0.708086 | 3 | 0 | 3 |
| GLRX | DRAM1 | 0.703921 | 11 | 0 | 11 |
| GLRX | SPI1 | 0.695089 | 5 | 0 | 4 |
| GLRX | CLEC2D | 0.692807 | 3 | 0 | 3 |
| GLRX | WDR81 | 0.692196 | 3 | 0 | 3 |
| GLRX | DNALI1 | 0.691414 | 3 | 0 | 3 |
| GLRX | BMPR2 | 0.68661 | 4 | 0 | 4 |
| GLRX | NCKIPSD | 0.684802 | 3 | 0 | 3 |
| GLRX | PIGS | 0.681472 | 3 | 0 | 3 |
| GLRX | TMEM200A | 0.679169 | 7 | 0 | 7 |
| GLRX | ITGAM | 0.678635 | 8 | 0 | 7 |
For details and further investigation, click here
