| Full name: patatin like phospholipase domain containing 5 | Alias Symbol: dJ388M5.4|GS2L | ||
| Type: protein-coding gene | Cytoband: 22q13.31 | ||
| Entrez ID: 150379 | HGNC ID: HGNC:24888 | Ensembl Gene: ENSG00000100341 | OMIM ID: 611589 |
| Drug and gene relationship at DGIdb | |||
Expression of PNPLA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNPLA5 | 150379 | 233597_at | -0.0350 | 0.9027 | |
| GSE26886 | PNPLA5 | 150379 | 233597_at | 0.1529 | 0.2268 | |
| GSE45670 | PNPLA5 | 150379 | 233597_at | 0.0625 | 0.5791 | |
| GSE53622 | PNPLA5 | 150379 | 91766 | -0.2213 | 0.0000 | |
| GSE53624 | PNPLA5 | 150379 | 91766 | -0.0830 | 0.1898 | |
| GSE63941 | PNPLA5 | 150379 | 233597_at | 0.2884 | 0.0339 | |
| GSE77861 | PNPLA5 | 150379 | 233597_at | -0.0662 | 0.5741 | |
| GSE97050 | PNPLA5 | 150379 | A_33_P3559060 | 0.0922 | 0.6351 | |
| SRP133303 | PNPLA5 | 150379 | RNAseq | 0.0311 | 0.8624 | |
| SRP193095 | PNPLA5 | 150379 | RNAseq | 0.0199 | 0.9019 | |
| TCGA | PNPLA5 | 150379 | RNAseq | 3.1582 | 0.0216 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PNPLA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNPLA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNPLA5 | 150379 | 5 | 7 | 18 | |
| GSE20123 | PNPLA5 | 150379 | 4 | 6 | 20 | |
| GSE43470 | PNPLA5 | 150379 | 3 | 6 | 34 | |
| GSE46452 | PNPLA5 | 150379 | 31 | 2 | 26 | |
| GSE47630 | PNPLA5 | 150379 | 9 | 4 | 27 | |
| GSE54993 | PNPLA5 | 150379 | 3 | 6 | 61 | |
| GSE54994 | PNPLA5 | 150379 | 11 | 8 | 34 | |
| GSE60625 | PNPLA5 | 150379 | 5 | 0 | 6 | |
| GSE74703 | PNPLA5 | 150379 | 3 | 4 | 29 | |
| GSE74704 | PNPLA5 | 150379 | 2 | 3 | 15 | |
| TCGA | PNPLA5 | 150379 | 26 | 15 | 55 |
Total number of gains: 102; Total number of losses: 61; Total Number of normals: 325.
Somatic mutations of PNPLA5:
Generating mutation plots.
Highly correlated genes for PNPLA5:
Showing top 20/251 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNPLA5 | LTC4S | 0.756644 | 3 | 0 | 3 |
| PNPLA5 | PALM3 | 0.75492 | 4 | 0 | 4 |
| PNPLA5 | SHROOM4 | 0.747092 | 3 | 0 | 3 |
| PNPLA5 | C1orf61 | 0.727438 | 3 | 0 | 3 |
| PNPLA5 | SEC13 | 0.722039 | 3 | 0 | 3 |
| PNPLA5 | RGL4 | 0.718031 | 3 | 0 | 3 |
| PNPLA5 | KCNT1 | 0.713127 | 4 | 0 | 3 |
| PNPLA5 | GALR2 | 0.712189 | 3 | 0 | 3 |
| PNPLA5 | MIXL1 | 0.70515 | 3 | 0 | 3 |
| PNPLA5 | POU1F1 | 0.700469 | 3 | 0 | 3 |
| PNPLA5 | CCNJL | 0.698592 | 3 | 0 | 3 |
| PNPLA5 | DUOXA2 | 0.692579 | 4 | 0 | 4 |
| PNPLA5 | VMO1 | 0.690648 | 3 | 0 | 3 |
| PNPLA5 | AGAP2 | 0.685641 | 4 | 0 | 4 |
| PNPLA5 | ANKRD33B | 0.684531 | 3 | 0 | 3 |
| PNPLA5 | ANKFN1 | 0.684202 | 4 | 0 | 3 |
| PNPLA5 | SLC22A8 | 0.681055 | 4 | 0 | 4 |
| PNPLA5 | JSRP1 | 0.679701 | 4 | 0 | 3 |
| PNPLA5 | TNF | 0.679356 | 3 | 0 | 3 |
| PNPLA5 | WDR55 | 0.678765 | 4 | 0 | 4 |
For details and further investigation, click here
