| Full name: leukocyte receptor tyrosine kinase | Alias Symbol: TYK1 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 4058 | HGNC ID: HGNC:6721 | Ensembl Gene: ENSG00000062524 | OMIM ID: 151520 |
| Drug and gene relationship at DGIdb | |||
Expression of LTK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LTK | 4058 | 217184_s_at | 0.0046 | 0.9883 | |
| GSE20347 | LTK | 4058 | 217184_s_at | 0.0003 | 0.9979 | |
| GSE23400 | LTK | 4058 | 217184_s_at | -0.0981 | 0.0044 | |
| GSE26886 | LTK | 4058 | 217184_s_at | 0.1615 | 0.1820 | |
| GSE29001 | LTK | 4058 | 217184_s_at | -0.1660 | 0.1694 | |
| GSE38129 | LTK | 4058 | 217184_s_at | -0.0471 | 0.7088 | |
| GSE45670 | LTK | 4058 | 217184_s_at | 0.1279 | 0.1490 | |
| GSE53622 | LTK | 4058 | 86210 | 0.4400 | 0.0000 | |
| GSE53624 | LTK | 4058 | 86210 | 0.3444 | 0.0000 | |
| GSE63941 | LTK | 4058 | 217184_s_at | 0.3701 | 0.0474 | |
| GSE77861 | LTK | 4058 | 217184_s_at | -0.1751 | 0.1037 | |
| GSE97050 | LTK | 4058 | A_33_P3371663 | 0.2798 | 0.2584 | |
| SRP133303 | LTK | 4058 | RNAseq | -0.5452 | 0.1380 | |
| SRP159526 | LTK | 4058 | RNAseq | 1.8120 | 0.0113 | |
| SRP219564 | LTK | 4058 | RNAseq | 0.6471 | 0.4148 | |
| TCGA | LTK | 4058 | RNAseq | -1.6052 | 0.0016 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by LTK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LTK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LTK | 4058 | 3 | 6 | 21 | |
| GSE20123 | LTK | 4058 | 3 | 6 | 21 | |
| GSE43470 | LTK | 4058 | 4 | 5 | 34 | |
| GSE46452 | LTK | 4058 | 3 | 7 | 49 | |
| GSE47630 | LTK | 4058 | 8 | 11 | 21 | |
| GSE54993 | LTK | 4058 | 4 | 6 | 60 | |
| GSE54994 | LTK | 4058 | 5 | 7 | 41 | |
| GSE60625 | LTK | 4058 | 4 | 0 | 7 | |
| GSE74703 | LTK | 4058 | 4 | 4 | 28 | |
| GSE74704 | LTK | 4058 | 2 | 4 | 14 | |
| TCGA | LTK | 4058 | 11 | 18 | 67 |
Total number of gains: 51; Total number of losses: 74; Total Number of normals: 363.
Somatic mutations of LTK:
Generating mutation plots.
Highly correlated genes for LTK:
Showing top 20/1207 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LTK | C2CD4D | 0.796774 | 3 | 0 | 3 |
| LTK | CDHR5 | 0.750704 | 5 | 0 | 5 |
| LTK | STRC | 0.748351 | 3 | 0 | 3 |
| LTK | PRR18 | 0.744027 | 3 | 0 | 3 |
| LTK | C9orf153 | 0.737701 | 3 | 0 | 3 |
| LTK | LRRC10 | 0.729234 | 3 | 0 | 3 |
| LTK | MS4A18 | 0.726365 | 3 | 0 | 3 |
| LTK | C1QL2 | 0.72622 | 3 | 0 | 3 |
| LTK | HRC | 0.724491 | 4 | 0 | 4 |
| LTK | LMAN1L | 0.722283 | 6 | 0 | 6 |
| LTK | MRGPRG | 0.720655 | 3 | 0 | 3 |
| LTK | GLI4 | 0.720359 | 3 | 0 | 3 |
| LTK | C10orf90 | 0.715353 | 3 | 0 | 3 |
| LTK | AKR7A3 | 0.711933 | 3 | 0 | 3 |
| LTK | DCDC1 | 0.708472 | 3 | 0 | 3 |
| LTK | DMC1 | 0.704994 | 3 | 0 | 3 |
| LTK | CACNG7 | 0.699981 | 3 | 0 | 3 |
| LTK | TUSC1 | 0.69976 | 3 | 0 | 3 |
| LTK | CPA2 | 0.697961 | 3 | 0 | 3 |
| LTK | SLC39A5 | 0.697051 | 3 | 0 | 3 |
For details and further investigation, click here
