| Full name: aldo-keto reductase family 7 member A3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 22977 | HGNC ID: HGNC:390 | Ensembl Gene: ENSG00000162482 | OMIM ID: 608477 |
| Drug and gene relationship at DGIdb | |||
Expression of AKR7A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR7A3 | 22977 | 216381_x_at | -0.0337 | 0.9599 | |
| GSE20347 | AKR7A3 | 22977 | 216381_x_at | -0.1965 | 0.0600 | |
| GSE23400 | AKR7A3 | 22977 | 216381_x_at | -0.2764 | 0.0000 | |
| GSE26886 | AKR7A3 | 22977 | 206469_x_at | -0.4521 | 0.0086 | |
| GSE29001 | AKR7A3 | 22977 | 216381_x_at | -0.5292 | 0.0290 | |
| GSE38129 | AKR7A3 | 22977 | 216381_x_at | -0.2992 | 0.1293 | |
| GSE45670 | AKR7A3 | 22977 | 206469_x_at | -0.3184 | 0.0352 | |
| GSE63941 | AKR7A3 | 22977 | 216381_x_at | -0.1220 | 0.7495 | |
| GSE77861 | AKR7A3 | 22977 | 216381_x_at | -0.4909 | 0.0176 | |
| GSE97050 | AKR7A3 | 22977 | A_23_P103968 | 0.1351 | 0.5720 | |
| SRP133303 | AKR7A3 | 22977 | RNAseq | 0.0574 | 0.9035 | |
| SRP159526 | AKR7A3 | 22977 | RNAseq | 0.0498 | 0.9254 | |
| SRP219564 | AKR7A3 | 22977 | RNAseq | 0.7784 | 0.2370 | |
| TCGA | AKR7A3 | 22977 | RNAseq | -2.6250 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AKR7A3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of AKR7A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR7A3 | 22977 | 0 | 5 | 25 | |
| GSE20123 | AKR7A3 | 22977 | 0 | 4 | 26 | |
| GSE43470 | AKR7A3 | 22977 | 0 | 8 | 35 | |
| GSE46452 | AKR7A3 | 22977 | 5 | 1 | 53 | |
| GSE47630 | AKR7A3 | 22977 | 8 | 3 | 29 | |
| GSE54993 | AKR7A3 | 22977 | 3 | 1 | 66 | |
| GSE54994 | AKR7A3 | 22977 | 11 | 4 | 38 | |
| GSE60625 | AKR7A3 | 22977 | 0 | 0 | 11 | |
| GSE74703 | AKR7A3 | 22977 | 0 | 5 | 31 | |
| GSE74704 | AKR7A3 | 22977 | 0 | 0 | 20 | |
| TCGA | AKR7A3 | 22977 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of AKR7A3:
Generating mutation plots.
Highly correlated genes for AKR7A3:
Showing top 20/344 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR7A3 | TRIM41 | 0.793402 | 3 | 0 | 3 |
| AKR7A3 | MRPS16 | 0.782391 | 3 | 0 | 3 |
| AKR7A3 | PARS2 | 0.752693 | 3 | 0 | 3 |
| AKR7A3 | MMAB | 0.728652 | 3 | 0 | 3 |
| AKR7A3 | FASTK | 0.7283 | 3 | 0 | 3 |
| AKR7A3 | RPIA | 0.71785 | 3 | 0 | 3 |
| AKR7A3 | MID1 | 0.713751 | 3 | 0 | 3 |
| AKR7A3 | LTK | 0.711933 | 3 | 0 | 3 |
| AKR7A3 | AIRE | 0.710305 | 4 | 0 | 4 |
| AKR7A3 | CLDN9 | 0.704383 | 3 | 0 | 3 |
| AKR7A3 | PPM1J | 0.703484 | 4 | 0 | 3 |
| AKR7A3 | NOBOX | 0.70069 | 3 | 0 | 3 |
| AKR7A3 | S100A16 | 0.697612 | 3 | 0 | 3 |
| AKR7A3 | NUDT16L1 | 0.69416 | 4 | 0 | 3 |
| AKR7A3 | CCDC157 | 0.691411 | 4 | 0 | 3 |
| AKR7A3 | FERD3L | 0.690572 | 3 | 0 | 3 |
| AKR7A3 | SLC23A3 | 0.687292 | 3 | 0 | 3 |
| AKR7A3 | CC2D1B | 0.683996 | 4 | 0 | 4 |
| AKR7A3 | RNF123 | 0.680784 | 4 | 0 | 4 |
| AKR7A3 | INO80C | 0.680215 | 3 | 0 | 3 |
For details and further investigation, click here
