| Full name: GLI family zinc finger 4 | Alias Symbol: HKR4|ZNF928 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 2738 | HGNC ID: HGNC:4320 | Ensembl Gene: ENSG00000250571 | OMIM ID: 165280 |
| Drug and gene relationship at DGIdb | |||
Expression of GLI4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLI4 | 2738 | 243076_x_at | -0.1738 | 0.3264 | |
| GSE26886 | GLI4 | 2738 | 243076_x_at | -0.2807 | 0.0109 | |
| GSE45670 | GLI4 | 2738 | 243076_x_at | 0.0857 | 0.3644 | |
| GSE53622 | GLI4 | 2738 | 59560 | 0.2219 | 0.0016 | |
| GSE53624 | GLI4 | 2738 | 59560 | 0.1594 | 0.0762 | |
| GSE63941 | GLI4 | 2738 | 243076_x_at | 0.1432 | 0.3120 | |
| GSE77861 | GLI4 | 2738 | 243076_x_at | -0.1714 | 0.1266 | |
| GSE97050 | GLI4 | 2738 | A_33_P3285715 | 0.1639 | 0.3950 | |
| SRP007169 | GLI4 | 2738 | RNAseq | -0.1173 | 0.8505 | |
| SRP064894 | GLI4 | 2738 | RNAseq | 0.6814 | 0.0236 | |
| SRP133303 | GLI4 | 2738 | RNAseq | -0.2030 | 0.1136 | |
| SRP159526 | GLI4 | 2738 | RNAseq | 0.2523 | 0.4050 | |
| SRP193095 | GLI4 | 2738 | RNAseq | 0.4882 | 0.0006 | |
| SRP219564 | GLI4 | 2738 | RNAseq | 0.5735 | 0.3691 | |
| TCGA | GLI4 | 2738 | RNAseq | 0.1745 | 0.0790 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GLI4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLI4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLI4 | 2738 | 17 | 1 | 12 | |
| GSE20123 | GLI4 | 2738 | 17 | 1 | 12 | |
| GSE43470 | GLI4 | 2738 | 17 | 2 | 24 | |
| GSE46452 | GLI4 | 2738 | 27 | 0 | 32 | |
| GSE47630 | GLI4 | 2738 | 23 | 1 | 16 | |
| GSE54993 | GLI4 | 2738 | 0 | 25 | 45 | |
| GSE54994 | GLI4 | 2738 | 39 | 1 | 13 | |
| GSE60625 | GLI4 | 2738 | 3 | 4 | 4 | |
| GSE74703 | GLI4 | 2738 | 15 | 1 | 20 | |
| GSE74704 | GLI4 | 2738 | 10 | 0 | 10 | |
| TCGA | GLI4 | 2738 | 64 | 2 | 30 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of GLI4:
Generating mutation plots.
Highly correlated genes for GLI4:
Showing top 20/292 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLI4 | TNNI2 | 0.789805 | 3 | 0 | 3 |
| GLI4 | CSH1 | 0.786245 | 3 | 0 | 3 |
| GLI4 | LCE1D | 0.769129 | 3 | 0 | 3 |
| GLI4 | RAX2 | 0.76373 | 3 | 0 | 3 |
| GLI4 | PDZD7 | 0.753848 | 3 | 0 | 3 |
| GLI4 | FLT4 | 0.741893 | 3 | 0 | 3 |
| GLI4 | GPR25 | 0.734535 | 3 | 0 | 3 |
| GLI4 | SPACA3 | 0.734414 | 4 | 0 | 3 |
| GLI4 | CHD5 | 0.732393 | 3 | 0 | 3 |
| GLI4 | CCDC154 | 0.721115 | 4 | 0 | 4 |
| GLI4 | LTK | 0.720359 | 3 | 0 | 3 |
| GLI4 | TSPO | 0.718572 | 3 | 0 | 3 |
| GLI4 | PIK3C2B | 0.710759 | 3 | 0 | 3 |
| GLI4 | BFSP2-AS1 | 0.710025 | 4 | 0 | 4 |
| GLI4 | CATSPERG | 0.708849 | 4 | 0 | 3 |
| GLI4 | CLDN9 | 0.707293 | 4 | 0 | 3 |
| GLI4 | SNORA68 | 0.706511 | 3 | 0 | 3 |
| GLI4 | RXFP3 | 0.706114 | 5 | 0 | 5 |
| GLI4 | SLC6A3 | 0.70432 | 3 | 0 | 3 |
| GLI4 | CAMKV | 0.702176 | 4 | 0 | 4 |
For details and further investigation, click here
