| Full name: alkaline phosphatase, biomineralization associated | Alias Symbol: TNSALP|TNALP|TNAP | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 249 | HGNC ID: HGNC:438 | Ensembl Gene: ENSG00000162551 | OMIM ID: 171760 |
| Drug and gene relationship at DGIdb | |||
Expression of ALPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALPL | 249 | 215783_s_at | 0.1439 | 0.8364 | |
| GSE20347 | ALPL | 249 | 215783_s_at | 0.0138 | 0.8690 | |
| GSE23400 | ALPL | 249 | 215783_s_at | -0.0274 | 0.3761 | |
| GSE26886 | ALPL | 249 | 215783_s_at | 0.0984 | 0.3570 | |
| GSE29001 | ALPL | 249 | 215783_s_at | -0.1868 | 0.2296 | |
| GSE38129 | ALPL | 249 | 215783_s_at | -0.0569 | 0.4583 | |
| GSE45670 | ALPL | 249 | 1557924_s_at | -0.0074 | 0.9438 | |
| GSE53622 | ALPL | 249 | 13763 | 0.0671 | 0.3426 | |
| GSE53624 | ALPL | 249 | 13763 | -0.1900 | 0.0497 | |
| GSE63941 | ALPL | 249 | 215783_s_at | 0.4997 | 0.5325 | |
| GSE77861 | ALPL | 249 | 215783_s_at | 0.0972 | 0.4103 | |
| GSE97050 | ALPL | 249 | A_24_P353619 | 0.2873 | 0.2900 | |
| SRP007169 | ALPL | 249 | RNAseq | 1.0119 | 0.2047 | |
| SRP064894 | ALPL | 249 | RNAseq | 0.9709 | 0.0034 | |
| SRP133303 | ALPL | 249 | RNAseq | 0.6602 | 0.0071 | |
| SRP159526 | ALPL | 249 | RNAseq | 0.6033 | 0.2587 | |
| SRP193095 | ALPL | 249 | RNAseq | 1.6065 | 0.0000 | |
| SRP219564 | ALPL | 249 | RNAseq | 1.1857 | 0.0502 | |
| TCGA | ALPL | 249 | RNAseq | -0.0085 | 0.9537 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ALPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALPL | 249 | 0 | 5 | 25 | |
| GSE20123 | ALPL | 249 | 0 | 4 | 26 | |
| GSE43470 | ALPL | 249 | 0 | 8 | 35 | |
| GSE46452 | ALPL | 249 | 5 | 1 | 53 | |
| GSE47630 | ALPL | 249 | 8 | 3 | 29 | |
| GSE54993 | ALPL | 249 | 3 | 1 | 66 | |
| GSE54994 | ALPL | 249 | 11 | 4 | 38 | |
| GSE60625 | ALPL | 249 | 0 | 0 | 11 | |
| GSE74703 | ALPL | 249 | 0 | 5 | 31 | |
| GSE74704 | ALPL | 249 | 0 | 0 | 20 | |
| TCGA | ALPL | 249 | 9 | 23 | 64 |
Total number of gains: 36; Total number of losses: 54; Total Number of normals: 398.
Somatic mutations of ALPL:
Generating mutation plots.
Highly correlated genes for ALPL:
Showing top 20/468 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALPL | ABCA4 | 0.84736 | 3 | 0 | 3 |
| ALPL | TNFSF11 | 0.764129 | 3 | 0 | 3 |
| ALPL | CHRND | 0.749865 | 3 | 0 | 3 |
| ALPL | GABRD | 0.746307 | 4 | 0 | 3 |
| ALPL | PABPN1L | 0.742972 | 3 | 0 | 3 |
| ALPL | CD274 | 0.739566 | 3 | 0 | 3 |
| ALPL | ZKSCAN2 | 0.736832 | 3 | 0 | 3 |
| ALPL | PANX2 | 0.736126 | 5 | 0 | 4 |
| ALPL | TRPA1 | 0.732734 | 3 | 0 | 3 |
| ALPL | TRIM17 | 0.731274 | 4 | 0 | 3 |
| ALPL | ITIH3 | 0.724526 | 3 | 0 | 3 |
| ALPL | ADAMTS13 | 0.724162 | 3 | 0 | 3 |
| ALPL | C10orf91 | 0.717655 | 3 | 0 | 3 |
| ALPL | SRPK3 | 0.716894 | 3 | 0 | 3 |
| ALPL | CCDC106 | 0.71437 | 3 | 0 | 3 |
| ALPL | SHH | 0.712375 | 3 | 0 | 3 |
| ALPL | TLR9 | 0.712252 | 3 | 0 | 3 |
| ALPL | SLC29A4 | 0.707852 | 3 | 0 | 3 |
| ALPL | LRIT1 | 0.703949 | 4 | 0 | 4 |
| ALPL | SIGIRR | 0.703276 | 3 | 0 | 3 |
For details and further investigation, click here
