| Full name: mannosidase alpha class 2A member 2 | Alias Symbol: MANA2X|HsT19662 | ||
| Type: protein-coding gene | Cytoband: 15q25 | ||
| Entrez ID: 4122 | HGNC ID: HGNC:6825 | Ensembl Gene: ENSG00000196547 | OMIM ID: 600988 |
| Drug and gene relationship at DGIdb | |||
Expression of MAN2A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAN2A2 | 4122 | 202032_s_at | -0.2420 | 0.3617 | |
| GSE20347 | MAN2A2 | 4122 | 202032_s_at | 0.2126 | 0.2868 | |
| GSE23400 | MAN2A2 | 4122 | 202032_s_at | -0.1707 | 0.0021 | |
| GSE26886 | MAN2A2 | 4122 | 202032_s_at | 0.0671 | 0.8301 | |
| GSE29001 | MAN2A2 | 4122 | 202032_s_at | 0.0507 | 0.8665 | |
| GSE38129 | MAN2A2 | 4122 | 202032_s_at | 0.0326 | 0.8448 | |
| GSE45670 | MAN2A2 | 4122 | 202032_s_at | -0.3016 | 0.1728 | |
| GSE53622 | MAN2A2 | 4122 | 2481 | 0.1821 | 0.0992 | |
| GSE53624 | MAN2A2 | 4122 | 112707 | -0.3073 | 0.0000 | |
| GSE63941 | MAN2A2 | 4122 | 202032_s_at | -0.4212 | 0.4024 | |
| GSE77861 | MAN2A2 | 4122 | 202032_s_at | -0.1137 | 0.5527 | |
| GSE97050 | MAN2A2 | 4122 | A_23_P37569 | -0.4427 | 0.2609 | |
| SRP007169 | MAN2A2 | 4122 | RNAseq | 1.6614 | 0.0009 | |
| SRP008496 | MAN2A2 | 4122 | RNAseq | 1.8437 | 0.0000 | |
| SRP064894 | MAN2A2 | 4122 | RNAseq | -0.3084 | 0.1197 | |
| SRP133303 | MAN2A2 | 4122 | RNAseq | -0.2723 | 0.1867 | |
| SRP159526 | MAN2A2 | 4122 | RNAseq | 0.3838 | 0.2757 | |
| SRP193095 | MAN2A2 | 4122 | RNAseq | 0.2752 | 0.1065 | |
| SRP219564 | MAN2A2 | 4122 | RNAseq | 0.0347 | 0.9412 | |
| TCGA | MAN2A2 | 4122 | RNAseq | -0.3133 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MAN2A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAN2A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAN2A2 | 4122 | 8 | 2 | 20 | |
| GSE20123 | MAN2A2 | 4122 | 8 | 2 | 20 | |
| GSE43470 | MAN2A2 | 4122 | 5 | 5 | 33 | |
| GSE46452 | MAN2A2 | 4122 | 3 | 7 | 49 | |
| GSE47630 | MAN2A2 | 4122 | 8 | 11 | 21 | |
| GSE54993 | MAN2A2 | 4122 | 4 | 6 | 60 | |
| GSE54994 | MAN2A2 | 4122 | 7 | 7 | 39 | |
| GSE60625 | MAN2A2 | 4122 | 4 | 0 | 7 | |
| GSE74703 | MAN2A2 | 4122 | 4 | 4 | 28 | |
| GSE74704 | MAN2A2 | 4122 | 4 | 2 | 14 | |
| TCGA | MAN2A2 | 4122 | 18 | 12 | 66 |
Total number of gains: 73; Total number of losses: 58; Total Number of normals: 357.
Somatic mutations of MAN2A2:
Generating mutation plots.
Highly correlated genes for MAN2A2:
Showing top 20/130 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAN2A2 | ZNF664 | 0.696375 | 3 | 0 | 3 |
| MAN2A2 | RASD1 | 0.681949 | 3 | 0 | 3 |
| MAN2A2 | ST7L | 0.671019 | 4 | 0 | 3 |
| MAN2A2 | UTRN | 0.6617 | 4 | 0 | 4 |
| MAN2A2 | HMGN3 | 0.659571 | 4 | 0 | 3 |
| MAN2A2 | ZDHHC1 | 0.64962 | 3 | 0 | 3 |
| MAN2A2 | ZNF839 | 0.639063 | 3 | 0 | 3 |
| MAN2A2 | FAS | 0.638217 | 3 | 0 | 3 |
| MAN2A2 | FIBCD1 | 0.629217 | 3 | 0 | 3 |
| MAN2A2 | CCDC146 | 0.623794 | 4 | 0 | 4 |
| MAN2A2 | TSPYL4 | 0.623765 | 4 | 0 | 3 |
| MAN2A2 | SLC26A10 | 0.619934 | 4 | 0 | 3 |
| MAN2A2 | LRCH3 | 0.619623 | 5 | 0 | 4 |
| MAN2A2 | MYCT1 | 0.619067 | 4 | 0 | 3 |
| MAN2A2 | PSEN2 | 0.617821 | 4 | 0 | 3 |
| MAN2A2 | VLDLR | 0.616557 | 3 | 0 | 3 |
| MAN2A2 | PROM1 | 0.615421 | 3 | 0 | 3 |
| MAN2A2 | CTPS2 | 0.614346 | 5 | 0 | 4 |
| MAN2A2 | LMBRD2 | 0.61376 | 3 | 0 | 3 |
| MAN2A2 | ZNF248 | 0.610018 | 6 | 0 | 4 |
For details and further investigation, click here
