LRCH3

 

Full name: leucine rich repeats and calponin homology domain containing 3 Alias Symbol: MGC4126
Type: protein-coding gene Cytoband: 3q29
Entrez ID: 84859 HGNC ID: HGNC:28637 Ensembl Gene: ENSG00000186001 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of LRCH3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LRCH3 84859 235347_at -0.7959 0.2135
GSE20347 LRCH3 84859 214739_at 0.4362 0.0029
GSE23400 LRCH3 84859 214739_at 0.2756 0.0000
GSE26886 LRCH3 84859 214739_at 1.1350 0.0000
GSE29001 LRCH3 84859 214739_at 0.5799 0.0089
GSE38129 LRCH3 84859 214739_at 0.3144 0.0249
GSE45670 LRCH3 84859 235347_at -0.5053 0.0253
GSE53622 LRCH3 84859 107946 0.3817 0.0001
GSE53624 LRCH3 84859 107946 0.3452 0.0000
GSE63941 LRCH3 84859 214739_at 0.0240 0.9611
GSE77861 LRCH3 84859 214739_at 0.4281 0.0578
GSE97050 LRCH3 84859 A_33_P3278801 0.4125 0.1655
SRP007169 LRCH3 84859 RNAseq 0.3811 0.3398
SRP008496 LRCH3 84859 RNAseq 0.7352 0.0174
SRP064894 LRCH3 84859 RNAseq 0.3396 0.0422
SRP133303 LRCH3 84859 RNAseq 0.6841 0.0000
SRP159526 LRCH3 84859 RNAseq 0.7495 0.0141
SRP193095 LRCH3 84859 RNAseq 0.6477 0.0000
SRP219564 LRCH3 84859 RNAseq 0.1313 0.6220
TCGA LRCH3 84859 RNAseq 0.0805 0.1754

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by LRCH3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LRCH3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LRCH3 84859 23 0 7
GSE20123 LRCH3 84859 23 0 7
GSE43470 LRCH3 84859 22 0 21
GSE46452 LRCH3 84859 20 1 38
GSE47630 LRCH3 84859 27 2 11
GSE54993 LRCH3 84859 1 22 47
GSE54994 LRCH3 84859 41 0 12
GSE60625 LRCH3 84859 0 6 5
GSE74703 LRCH3 84859 20 0 16
GSE74704 LRCH3 84859 14 0 6
TCGA LRCH3 84859 76 1 19

Total number of gains: 267; Total number of losses: 32; Total Number of normals: 189.  

 

Somatic mutations of LRCH3:

 

Generating mutation plots.

 

Highly correlated genes for LRCH3:

 

Showing top 20/717 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LRCH3POLK0.824928303
LRCH3ALKBH60.819085303
LRCH3SNAPC20.800827303
LRCH3PHF200.794107303
LRCH3DDX60L0.784344303
LRCH3PET1170.775106303
LRCH3IKBIP0.765715303
LRCH3ACAD110.75847303
LRCH3PKN30.753127303
LRCH3GNB50.747677505
LRCH3SLC6A60.746633303
LRCH3DNAJC180.741243303
LRCH3ARHGEF330.740365303
LRCH3TAS2R430.740032303
LRCH3FKBP110.737571303
LRCH3CLASRP0.728413404
LRCH3RPS270.727895303
LRCH3ZNF3580.721193404
LRCH3ENG0.710714303
LRCH3RILPL20.710224403

For details and further investigation, click here