| Full name: mannosidase beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q24 | ||
| Entrez ID: 4126 | HGNC ID: HGNC:6831 | Ensembl Gene: ENSG00000109323 | OMIM ID: 609489 |
| Drug and gene relationship at DGIdb | |||
Expression of MANBA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MANBA | 4126 | 203778_at | 0.4781 | 0.1299 | |
| GSE20347 | MANBA | 4126 | 203778_at | 0.2684 | 0.0021 | |
| GSE23400 | MANBA | 4126 | 203778_at | 0.2009 | 0.0000 | |
| GSE26886 | MANBA | 4126 | 203778_at | 1.3042 | 0.0000 | |
| GSE29001 | MANBA | 4126 | 203778_at | 0.3836 | 0.0208 | |
| GSE38129 | MANBA | 4126 | 203778_at | 0.2170 | 0.1033 | |
| GSE45670 | MANBA | 4126 | 203778_at | 0.0413 | 0.8494 | |
| GSE53622 | MANBA | 4126 | 67264 | 0.4967 | 0.0000 | |
| GSE53624 | MANBA | 4126 | 67264 | 0.2060 | 0.0061 | |
| GSE63941 | MANBA | 4126 | 203778_at | -1.7238 | 0.0004 | |
| GSE77861 | MANBA | 4126 | 203778_at | 0.4088 | 0.1588 | |
| GSE97050 | MANBA | 4126 | A_23_P258698 | 0.2094 | 0.2978 | |
| SRP007169 | MANBA | 4126 | RNAseq | 1.7930 | 0.0001 | |
| SRP008496 | MANBA | 4126 | RNAseq | 1.9866 | 0.0000 | |
| SRP064894 | MANBA | 4126 | RNAseq | 0.7505 | 0.0000 | |
| SRP133303 | MANBA | 4126 | RNAseq | 0.6121 | 0.0006 | |
| SRP159526 | MANBA | 4126 | RNAseq | 0.4985 | 0.0261 | |
| SRP193095 | MANBA | 4126 | RNAseq | 0.5127 | 0.0004 | |
| SRP219564 | MANBA | 4126 | RNAseq | 0.6067 | 0.1233 | |
| TCGA | MANBA | 4126 | RNAseq | -0.1792 | 0.0022 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by MANBA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MANBA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MANBA | 4126 | 0 | 12 | 18 | |
| GSE20123 | MANBA | 4126 | 0 | 12 | 18 | |
| GSE43470 | MANBA | 4126 | 0 | 13 | 30 | |
| GSE46452 | MANBA | 4126 | 1 | 36 | 22 | |
| GSE47630 | MANBA | 4126 | 0 | 20 | 20 | |
| GSE54993 | MANBA | 4126 | 9 | 0 | 61 | |
| GSE54994 | MANBA | 4126 | 1 | 10 | 42 | |
| GSE60625 | MANBA | 4126 | 0 | 3 | 8 | |
| GSE74703 | MANBA | 4126 | 0 | 11 | 25 | |
| GSE74704 | MANBA | 4126 | 0 | 6 | 14 | |
| TCGA | MANBA | 4126 | 8 | 39 | 49 |
Total number of gains: 19; Total number of losses: 162; Total Number of normals: 307.
Somatic mutations of MANBA:
Generating mutation plots.
Highly correlated genes for MANBA:
Showing top 20/372 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MANBA | SPATA17 | 0.758767 | 3 | 0 | 3 |
| MANBA | TMEM163 | 0.722443 | 4 | 0 | 3 |
| MANBA | ZNF77 | 0.719577 | 3 | 0 | 3 |
| MANBA | ARID3A | 0.699319 | 4 | 0 | 4 |
| MANBA | ZNF511 | 0.697511 | 3 | 0 | 3 |
| MANBA | NEDD9 | 0.693021 | 4 | 0 | 3 |
| MANBA | EMILIN1 | 0.692057 | 4 | 0 | 3 |
| MANBA | PDCD2L | 0.680852 | 3 | 0 | 3 |
| MANBA | ALDH16A1 | 0.677123 | 3 | 0 | 3 |
| MANBA | ZFPM2 | 0.670777 | 4 | 0 | 4 |
| MANBA | LGR6 | 0.670129 | 3 | 0 | 3 |
| MANBA | POLR3A | 0.669057 | 4 | 0 | 4 |
| MANBA | TCEAL7 | 0.666246 | 3 | 0 | 3 |
| MANBA | COTL1 | 0.657349 | 4 | 0 | 4 |
| MANBA | ANKRD52 | 0.65326 | 3 | 0 | 3 |
| MANBA | BCAT1 | 0.651547 | 5 | 0 | 5 |
| MANBA | LIN28B | 0.64979 | 3 | 0 | 3 |
| MANBA | KIF26B | 0.640663 | 6 | 0 | 4 |
| MANBA | CHST10 | 0.640138 | 5 | 0 | 3 |
| MANBA | TFPI2 | 0.639957 | 4 | 0 | 4 |
For details and further investigation, click here
