| Full name: coactosin like F-actin binding protein 1 | Alias Symbol: CLP | ||
| Type: protein-coding gene | Cytoband: 16q24.1 | ||
| Entrez ID: 23406 | HGNC ID: HGNC:18304 | Ensembl Gene: ENSG00000103187 | OMIM ID: 606748 |
| Drug and gene relationship at DGIdb | |||
Expression of COTL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COTL1 | 23406 | 224583_at | 1.2274 | 0.1030 | |
| GSE26886 | COTL1 | 23406 | 224583_at | 0.4603 | 0.3535 | |
| GSE45670 | COTL1 | 23406 | 224583_at | 0.7108 | 0.0380 | |
| GSE53622 | COTL1 | 23406 | 56973 | 0.7303 | 0.0000 | |
| GSE53624 | COTL1 | 23406 | 56973 | 0.7840 | 0.0000 | |
| GSE63941 | COTL1 | 23406 | 224583_at | -1.7582 | 0.1418 | |
| GSE77861 | COTL1 | 23406 | 224583_at | 1.3863 | 0.0085 | |
| GSE97050 | COTL1 | 23406 | A_24_P416131 | 1.0258 | 0.1470 | |
| SRP007169 | COTL1 | 23406 | RNAseq | 1.6451 | 0.0055 | |
| SRP008496 | COTL1 | 23406 | RNAseq | 1.5079 | 0.0019 | |
| SRP064894 | COTL1 | 23406 | RNAseq | 1.1776 | 0.0000 | |
| SRP133303 | COTL1 | 23406 | RNAseq | 0.8952 | 0.0000 | |
| SRP159526 | COTL1 | 23406 | RNAseq | 0.2590 | 0.6231 | |
| SRP193095 | COTL1 | 23406 | RNAseq | 0.5439 | 0.0466 | |
| SRP219564 | COTL1 | 23406 | RNAseq | 1.1338 | 0.0267 | |
| TCGA | COTL1 | 23406 | RNAseq | -0.1371 | 0.0585 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by COTL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COTL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COTL1 | 23406 | 4 | 5 | 21 | |
| GSE20123 | COTL1 | 23406 | 4 | 5 | 21 | |
| GSE43470 | COTL1 | 23406 | 2 | 10 | 31 | |
| GSE46452 | COTL1 | 23406 | 37 | 2 | 20 | |
| GSE47630 | COTL1 | 23406 | 11 | 9 | 20 | |
| GSE54993 | COTL1 | 23406 | 3 | 4 | 63 | |
| GSE54994 | COTL1 | 23406 | 8 | 10 | 35 | |
| GSE60625 | COTL1 | 23406 | 4 | 0 | 7 | |
| GSE74703 | COTL1 | 23406 | 2 | 7 | 27 | |
| GSE74704 | COTL1 | 23406 | 3 | 3 | 14 | |
| TCGA | COTL1 | 23406 | 26 | 16 | 54 |
Total number of gains: 104; Total number of losses: 71; Total Number of normals: 313.
Somatic mutations of COTL1:
Generating mutation plots.
Highly correlated genes for COTL1:
Showing top 20/693 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COTL1 | RAC2 | 0.729528 | 7 | 0 | 7 |
| COTL1 | PSMD11 | 0.722544 | 3 | 0 | 3 |
| COTL1 | ABCC5 | 0.721844 | 3 | 0 | 3 |
| COTL1 | PLA2G7 | 0.714004 | 8 | 0 | 7 |
| COTL1 | RNASE6 | 0.702617 | 3 | 0 | 3 |
| COTL1 | UXS1 | 0.701532 | 3 | 0 | 3 |
| COTL1 | CDH3 | 0.699509 | 5 | 0 | 5 |
| COTL1 | CCT5 | 0.694918 | 3 | 0 | 3 |
| COTL1 | BCL2A1 | 0.689683 | 6 | 0 | 6 |
| COTL1 | FCER1G | 0.687911 | 6 | 0 | 5 |
| COTL1 | SLC7A7 | 0.685702 | 8 | 0 | 7 |
| COTL1 | SNX10 | 0.685333 | 8 | 0 | 7 |
| COTL1 | BMP1 | 0.685285 | 3 | 0 | 3 |
| COTL1 | KIR3DL1 | 0.67868 | 3 | 0 | 3 |
| COTL1 | MYBBP1A | 0.674624 | 3 | 0 | 3 |
| COTL1 | UBE2Z | 0.674443 | 3 | 0 | 3 |
| COTL1 | FCGR3B | 0.673895 | 4 | 0 | 4 |
| COTL1 | AGTRAP | 0.671572 | 4 | 0 | 3 |
| COTL1 | UTP6 | 0.668082 | 3 | 0 | 3 |
| COTL1 | BRI3BP | 0.666969 | 3 | 0 | 3 |
For details and further investigation, click here
