| Full name: RNA polymerase III subunit A | Alias Symbol: RPC1|RPC155|hRPC155 | ||
| Type: protein-coding gene | Cytoband: 10q22.3 | ||
| Entrez ID: 11128 | HGNC ID: HGNC:30074 | Ensembl Gene: ENSG00000148606 | OMIM ID: 614258 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR3A | 11128 | 231763_at | 0.6715 | 0.0719 | |
| GSE26886 | POLR3A | 11128 | 227872_at | 0.5930 | 0.0060 | |
| GSE45670 | POLR3A | 11128 | 231763_at | 0.2535 | 0.0504 | |
| GSE53622 | POLR3A | 11128 | 21202 | 0.2162 | 0.0001 | |
| GSE53624 | POLR3A | 11128 | 21202 | 0.3911 | 0.0000 | |
| GSE63941 | POLR3A | 11128 | 231763_at | 0.0271 | 0.9477 | |
| GSE77861 | POLR3A | 11128 | 231763_at | 0.1584 | 0.2938 | |
| GSE97050 | POLR3A | 11128 | A_33_P3322724 | 0.2193 | 0.4977 | |
| SRP007169 | POLR3A | 11128 | RNAseq | 1.4945 | 0.0013 | |
| SRP008496 | POLR3A | 11128 | RNAseq | 1.0893 | 0.0016 | |
| SRP064894 | POLR3A | 11128 | RNAseq | 0.2371 | 0.0306 | |
| SRP133303 | POLR3A | 11128 | RNAseq | 0.3015 | 0.0017 | |
| SRP159526 | POLR3A | 11128 | RNAseq | 0.0504 | 0.7918 | |
| SRP193095 | POLR3A | 11128 | RNAseq | 0.3756 | 0.0000 | |
| SRP219564 | POLR3A | 11128 | RNAseq | 0.3811 | 0.2341 | |
| TCGA | POLR3A | 11128 | RNAseq | 0.0297 | 0.6005 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by POLR3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR3A | 11128 | 3 | 5 | 22 | |
| GSE20123 | POLR3A | 11128 | 3 | 4 | 23 | |
| GSE43470 | POLR3A | 11128 | 1 | 7 | 35 | |
| GSE46452 | POLR3A | 11128 | 0 | 11 | 48 | |
| GSE47630 | POLR3A | 11128 | 2 | 14 | 24 | |
| GSE54993 | POLR3A | 11128 | 7 | 0 | 63 | |
| GSE54994 | POLR3A | 11128 | 1 | 11 | 41 | |
| GSE60625 | POLR3A | 11128 | 0 | 0 | 11 | |
| GSE74703 | POLR3A | 11128 | 1 | 4 | 31 | |
| GSE74704 | POLR3A | 11128 | 1 | 2 | 17 | |
| TCGA | POLR3A | 11128 | 10 | 24 | 62 |
Total number of gains: 29; Total number of losses: 82; Total Number of normals: 377.
Somatic mutations of POLR3A:
Generating mutation plots.
Highly correlated genes for POLR3A:
Showing top 20/248 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR3A | TRIM11 | 0.773328 | 3 | 0 | 3 |
| POLR3A | UBE2S | 0.743114 | 4 | 0 | 4 |
| POLR3A | ZNF205 | 0.721298 | 3 | 0 | 3 |
| POLR3A | HSPBAP1 | 0.716109 | 3 | 0 | 3 |
| POLR3A | LRRC69 | 0.714456 | 3 | 0 | 3 |
| POLR3A | CHGB | 0.705306 | 3 | 0 | 3 |
| POLR3A | CHP2 | 0.703284 | 3 | 0 | 3 |
| POLR3A | GPR180 | 0.698616 | 4 | 0 | 3 |
| POLR3A | PRR15 | 0.69757 | 3 | 0 | 3 |
| POLR3A | PODXL2 | 0.696561 | 3 | 0 | 3 |
| POLR3A | MBD6 | 0.694982 | 3 | 0 | 3 |
| POLR3A | MTERF1 | 0.692728 | 3 | 0 | 3 |
| POLR3A | PRPF3 | 0.689314 | 3 | 0 | 3 |
| POLR3A | ZNF639 | 0.686822 | 3 | 0 | 3 |
| POLR3A | TNFRSF25 | 0.686436 | 3 | 0 | 3 |
| POLR3A | LIPE | 0.68178 | 3 | 0 | 3 |
| POLR3A | BAZ2A | 0.674363 | 3 | 0 | 3 |
| POLR3A | PRPF19 | 0.670905 | 4 | 0 | 3 |
| POLR3A | MANBA | 0.669057 | 4 | 0 | 4 |
| POLR3A | FAM24B | 0.665752 | 4 | 0 | 3 |
For details and further investigation, click here
