| Full name: branched chain amino acid transaminase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 586 | HGNC ID: HGNC:976 | Ensembl Gene: ENSG00000060982 | OMIM ID: 113520 |
| Drug and gene relationship at DGIdb | |||
Expression of BCAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCAT1 | 586 | 225285_at | 1.3242 | 0.1974 | |
| GSE20347 | BCAT1 | 586 | 214390_s_at | 0.4619 | 0.0011 | |
| GSE23400 | BCAT1 | 586 | 214390_s_at | 0.2448 | 0.0062 | |
| GSE26886 | BCAT1 | 586 | 225285_at | 2.7294 | 0.0009 | |
| GSE29001 | BCAT1 | 586 | 214390_s_at | 0.0394 | 0.8546 | |
| GSE38129 | BCAT1 | 586 | 214390_s_at | 0.4662 | 0.0006 | |
| GSE45670 | BCAT1 | 586 | 225285_at | 1.4632 | 0.0201 | |
| GSE53622 | BCAT1 | 586 | 50657 | 2.3215 | 0.0000 | |
| GSE53624 | BCAT1 | 586 | 50657 | 2.8389 | 0.0000 | |
| GSE63941 | BCAT1 | 586 | 225285_at | -2.7889 | 0.2056 | |
| GSE77861 | BCAT1 | 586 | 225285_at | 2.0917 | 0.0332 | |
| GSE97050 | BCAT1 | 586 | A_24_P52921 | 0.9246 | 0.1403 | |
| SRP007169 | BCAT1 | 586 | RNAseq | 5.8958 | 0.0000 | |
| SRP008496 | BCAT1 | 586 | RNAseq | 4.6114 | 0.0000 | |
| SRP064894 | BCAT1 | 586 | RNAseq | 2.4642 | 0.0000 | |
| SRP133303 | BCAT1 | 586 | RNAseq | 1.9301 | 0.0000 | |
| SRP159526 | BCAT1 | 586 | RNAseq | 2.0289 | 0.0000 | |
| SRP193095 | BCAT1 | 586 | RNAseq | 1.8530 | 0.0000 | |
| SRP219564 | BCAT1 | 586 | RNAseq | 2.2582 | 0.0000 | |
| TCGA | BCAT1 | 586 | RNAseq | 0.3687 | 0.0113 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by BCAT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCAT1 | 586 | 10 | 1 | 19 | |
| GSE20123 | BCAT1 | 586 | 10 | 1 | 19 | |
| GSE43470 | BCAT1 | 586 | 9 | 4 | 30 | |
| GSE46452 | BCAT1 | 586 | 10 | 1 | 48 | |
| GSE47630 | BCAT1 | 586 | 15 | 0 | 25 | |
| GSE54993 | BCAT1 | 586 | 0 | 9 | 61 | |
| GSE54994 | BCAT1 | 586 | 11 | 2 | 40 | |
| GSE60625 | BCAT1 | 586 | 0 | 1 | 10 | |
| GSE74703 | BCAT1 | 586 | 9 | 3 | 24 | |
| GSE74704 | BCAT1 | 586 | 6 | 1 | 13 | |
| TCGA | BCAT1 | 586 | 43 | 4 | 49 |
Total number of gains: 123; Total number of losses: 27; Total Number of normals: 338.
Somatic mutations of BCAT1:
Generating mutation plots.
Highly correlated genes for BCAT1:
Showing top 20/776 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCAT1 | CD276 | 0.694101 | 5 | 0 | 5 |
| BCAT1 | SIX4 | 0.689647 | 6 | 0 | 5 |
| BCAT1 | CTHRC1 | 0.680609 | 9 | 0 | 7 |
| BCAT1 | C1QTNF6 | 0.676958 | 5 | 0 | 4 |
| BCAT1 | DRAM1 | 0.67607 | 5 | 0 | 5 |
| BCAT1 | WDR54 | 0.67409 | 6 | 0 | 5 |
| BCAT1 | JOSD1 | 0.671466 | 5 | 0 | 4 |
| BCAT1 | CD14 | 0.671292 | 4 | 0 | 4 |
| BCAT1 | LPCAT1 | 0.668606 | 7 | 0 | 5 |
| BCAT1 | DCBLD2 | 0.667624 | 6 | 0 | 5 |
| BCAT1 | HTRA1 | 0.667456 | 6 | 0 | 5 |
| BCAT1 | KNSTRN | 0.664412 | 6 | 0 | 6 |
| BCAT1 | NFKBIE | 0.662064 | 5 | 0 | 5 |
| BCAT1 | SH3BP4 | 0.660762 | 8 | 0 | 6 |
| BCAT1 | DNAJC10 | 0.658709 | 7 | 0 | 6 |
| BCAT1 | BCL2A1 | 0.657303 | 5 | 0 | 5 |
| BCAT1 | BOP1 | 0.657254 | 3 | 0 | 3 |
| BCAT1 | C16orf74 | 0.654145 | 5 | 0 | 5 |
| BCAT1 | CALU | 0.653633 | 6 | 0 | 5 |
| BCAT1 | SH3PXD2B | 0.652671 | 5 | 0 | 4 |
For details and further investigation, click here
