| Full name: tissue factor pathway inhibitor 2 | Alias Symbol: PP5|TFPI-2|REF1 | ||
| Type: protein-coding gene | Cytoband: 7q21.3 | ||
| Entrez ID: 7980 | HGNC ID: HGNC:11761 | Ensembl Gene: ENSG00000105825 | OMIM ID: 600033 |
| Drug and gene relationship at DGIdb | |||
Expression of TFPI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TFPI2 | 7980 | 209278_s_at | 0.1596 | 0.9307 | |
| GSE20347 | TFPI2 | 7980 | 209278_s_at | 0.1388 | 0.3265 | |
| GSE23400 | TFPI2 | 7980 | 209278_s_at | 0.1314 | 0.0415 | |
| GSE26886 | TFPI2 | 7980 | 209278_s_at | 1.8995 | 0.0030 | |
| GSE29001 | TFPI2 | 7980 | 209278_s_at | 0.8138 | 0.1585 | |
| GSE38129 | TFPI2 | 7980 | 209278_s_at | 0.0890 | 0.7719 | |
| GSE45670 | TFPI2 | 7980 | 209278_s_at | 0.5956 | 0.5041 | |
| GSE53622 | TFPI2 | 7980 | 127508 | -0.2265 | 0.2827 | |
| GSE53624 | TFPI2 | 7980 | 127508 | 0.6075 | 0.0019 | |
| GSE63941 | TFPI2 | 7980 | 209278_s_at | -7.9903 | 0.0002 | |
| GSE77861 | TFPI2 | 7980 | 209278_s_at | 0.1711 | 0.6280 | |
| GSE97050 | TFPI2 | 7980 | A_23_P393620 | 0.9381 | 0.2330 | |
| SRP133303 | TFPI2 | 7980 | RNAseq | 2.9192 | 0.0000 | |
| SRP159526 | TFPI2 | 7980 | RNAseq | 2.2841 | 0.0009 | |
| SRP219564 | TFPI2 | 7980 | RNAseq | 4.1214 | 0.0000 | |
| TCGA | TFPI2 | 7980 | RNAseq | 0.8231 | 0.0509 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by TFPI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TFPI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TFPI2 | 7980 | 13 | 0 | 17 | |
| GSE20123 | TFPI2 | 7980 | 13 | 0 | 17 | |
| GSE43470 | TFPI2 | 7980 | 7 | 1 | 35 | |
| GSE46452 | TFPI2 | 7980 | 12 | 0 | 47 | |
| GSE47630 | TFPI2 | 7980 | 9 | 2 | 29 | |
| GSE54993 | TFPI2 | 7980 | 1 | 9 | 60 | |
| GSE54994 | TFPI2 | 7980 | 16 | 2 | 35 | |
| GSE60625 | TFPI2 | 7980 | 0 | 5 | 6 | |
| GSE74703 | TFPI2 | 7980 | 6 | 1 | 29 | |
| GSE74704 | TFPI2 | 7980 | 9 | 0 | 11 | |
| TCGA | TFPI2 | 7980 | 56 | 4 | 36 |
Total number of gains: 142; Total number of losses: 24; Total Number of normals: 322.
Somatic mutations of TFPI2:
Generating mutation plots.
Highly correlated genes for TFPI2:
Showing top 20/177 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TFPI2 | CPXM1 | 0.686664 | 3 | 0 | 3 |
| TFPI2 | C8orf34 | 0.651412 | 3 | 0 | 3 |
| TFPI2 | SLC38A11 | 0.648097 | 3 | 0 | 3 |
| TFPI2 | SH2D5 | 0.641864 | 4 | 0 | 3 |
| TFPI2 | MANBA | 0.639957 | 4 | 0 | 4 |
| TFPI2 | PTX3 | 0.63361 | 5 | 0 | 4 |
| TFPI2 | IL1R1 | 0.626833 | 3 | 0 | 3 |
| TFPI2 | SLFN11 | 0.620941 | 4 | 0 | 4 |
| TFPI2 | ADAMTS6 | 0.616502 | 4 | 0 | 3 |
| TFPI2 | CHSY3 | 0.615743 | 5 | 0 | 4 |
| TFPI2 | CYP24A1 | 0.615718 | 4 | 0 | 4 |
| TFPI2 | BTBD16 | 0.614274 | 4 | 0 | 4 |
| TFPI2 | NID2 | 0.612896 | 6 | 0 | 4 |
| TFPI2 | COL12A1 | 0.607025 | 4 | 0 | 4 |
| TFPI2 | CCR1 | 0.606152 | 4 | 0 | 3 |
| TFPI2 | PF4V1 | 0.604643 | 4 | 0 | 3 |
| TFPI2 | TNFSF13B | 0.602112 | 4 | 0 | 3 |
| TFPI2 | DIRAS3 | 0.601838 | 4 | 0 | 3 |
| TFPI2 | RANBP1 | 0.601457 | 4 | 0 | 3 |
| TFPI2 | MAP7D1 | 0.600089 | 4 | 0 | 4 |
For details and further investigation, click here
