| Full name: lin-28 homolog B | Alias Symbol: FLJ16517|CSDD2 | ||
| Type: protein-coding gene | Cytoband: 6q16.3-q21 | ||
| Entrez ID: 389421 | HGNC ID: HGNC:32207 | Ensembl Gene: ENSG00000187772 | OMIM ID: 611044 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LIN28B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIN28B | 389421 | 229349_at | 1.7451 | 0.2074 | |
| GSE26886 | LIN28B | 389421 | 229349_at | 0.8055 | 0.0092 | |
| GSE45670 | LIN28B | 389421 | 229349_at | 0.5289 | 0.1821 | |
| GSE53622 | LIN28B | 389421 | 58703 | 1.1134 | 0.0000 | |
| GSE53624 | LIN28B | 389421 | 58703 | 1.7385 | 0.0000 | |
| GSE63941 | LIN28B | 389421 | 229349_at | 1.5223 | 0.3774 | |
| GSE77861 | LIN28B | 389421 | 229349_at | -0.0124 | 0.9399 | |
| GSE97050 | LIN28B | 389421 | A_33_P3220615 | 0.0793 | 0.7367 | |
| TCGA | LIN28B | 389421 | RNAseq | 4.0609 | 0.0014 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LIN28B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIN28B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIN28B | 389421 | 2 | 3 | 25 | |
| GSE20123 | LIN28B | 389421 | 2 | 2 | 26 | |
| GSE43470 | LIN28B | 389421 | 3 | 1 | 39 | |
| GSE46452 | LIN28B | 389421 | 2 | 11 | 46 | |
| GSE47630 | LIN28B | 389421 | 8 | 5 | 27 | |
| GSE54993 | LIN28B | 389421 | 3 | 2 | 65 | |
| GSE54994 | LIN28B | 389421 | 8 | 8 | 37 | |
| GSE60625 | LIN28B | 389421 | 0 | 2 | 9 | |
| GSE74703 | LIN28B | 389421 | 2 | 1 | 33 | |
| GSE74704 | LIN28B | 389421 | 1 | 0 | 19 | |
| TCGA | LIN28B | 389421 | 6 | 25 | 65 |
Total number of gains: 37; Total number of losses: 60; Total Number of normals: 391.
Somatic mutations of LIN28B:
Generating mutation plots.
Highly correlated genes for LIN28B:
Showing top 20/49 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIN28B | ARID3A | 0.721011 | 4 | 0 | 4 |
| LIN28B | WASIR1 | 0.699149 | 3 | 0 | 3 |
| LIN28B | AGAP2 | 0.696039 | 3 | 0 | 3 |
| LIN28B | TREM1 | 0.695696 | 4 | 0 | 3 |
| LIN28B | ZBTB24 | 0.692188 | 3 | 0 | 3 |
| LIN28B | WNT1 | 0.685451 | 3 | 0 | 3 |
| LIN28B | HSD17B3 | 0.656642 | 3 | 0 | 3 |
| LIN28B | VAV2 | 0.656088 | 4 | 0 | 3 |
| LIN28B | CEP164 | 0.650335 | 3 | 0 | 3 |
| LIN28B | MANBA | 0.64979 | 3 | 0 | 3 |
| LIN28B | FLCN | 0.64856 | 4 | 0 | 4 |
| LIN28B | NFKBIE | 0.645702 | 4 | 0 | 4 |
| LIN28B | DEFB126 | 0.644774 | 3 | 0 | 3 |
| LIN28B | PINX1 | 0.638571 | 4 | 0 | 4 |
| LIN28B | ZNF697 | 0.633372 | 4 | 0 | 3 |
| LIN28B | REM2 | 0.62731 | 3 | 0 | 3 |
| LIN28B | CALB1 | 0.617566 | 3 | 0 | 3 |
| LIN28B | DAPK2 | 0.616309 | 4 | 0 | 3 |
| LIN28B | ATP8B3 | 0.606979 | 3 | 0 | 3 |
| LIN28B | SAGE1 | 0.603128 | 4 | 0 | 3 |
For details and further investigation, click here
