MAP3K1

 

Full name: mitogen-activated protein kinase kinase kinase 1 Alias Symbol: MEKK|MAPKKK1
Type: protein-coding gene Cytoband: 5q11.2
Entrez ID: 4214 HGNC ID: HGNC:6848 Ensembl Gene: ENSG00000095015 OMIM ID: 600982
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MAP3K1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
hsa05161Hepatitis B
hsa05166HTLV-I infection

 

Expression of MAP3K1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAP3K1 4214 225927_at -0.3710 0.4548
GSE20347 MAP3K1 4214 214786_at -0.3957 0.0002
GSE23400 MAP3K1 4214 214786_at -0.1246 0.0011
GSE26886 MAP3K1 4214 225927_at -1.4351 0.0001
GSE29001 MAP3K1 4214 214786_at -0.2186 0.1312
GSE38129 MAP3K1 4214 214786_at -0.3166 0.0022
GSE45670 MAP3K1 4214 225927_at -0.4226 0.0584
GSE53622 MAP3K1 4214 35247 -0.7948 0.0000
GSE53624 MAP3K1 4214 35247 -0.8191 0.0000
GSE63941 MAP3K1 4214 225927_at 0.6634 0.2300
GSE77861 MAP3K1 4214 225927_at -1.3423 0.0303
GSE97050 MAP3K1 4214 A_33_P3368139 -0.6695 0.3038
SRP007169 MAP3K1 4214 RNAseq -0.9106 0.0577
SRP008496 MAP3K1 4214 RNAseq -0.9057 0.0020
SRP064894 MAP3K1 4214 RNAseq -1.0875 0.0000
SRP133303 MAP3K1 4214 RNAseq -1.0942 0.0000
SRP159526 MAP3K1 4214 RNAseq -1.1124 0.0040
SRP193095 MAP3K1 4214 RNAseq -1.0738 0.0000
SRP219564 MAP3K1 4214 RNAseq -1.0898 0.0548
TCGA MAP3K1 4214 RNAseq 0.1108 0.1370

Upregulated datasets: 0; Downregulated datasets: 6.  

 

Survival by MAP3K1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAP3K1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP3K1 4214 0 13 17
GSE20123 MAP3K1 4214 0 13 17
GSE43470 MAP3K1 4214 1 12 30
GSE46452 MAP3K1 4214 0 28 31
GSE47630 MAP3K1 4214 2 16 22
GSE54993 MAP3K1 4214 8 1 61
GSE54994 MAP3K1 4214 2 19 32
GSE60625 MAP3K1 4214 0 0 11
GSE74703 MAP3K1 4214 1 9 26
GSE74704 MAP3K1 4214 0 6 14
TCGA MAP3K1 4214 7 46 43

Total number of gains: 21; Total number of losses: 163; Total Number of normals: 304.  

 

Somatic mutations of MAP3K1:

 

Generating mutation plots.

 

Highly correlated genes for MAP3K1:

 

Showing top 20/1473 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP3K1SUSD10.82196303
MAP3K1CCNYL10.791996505
MAP3K1VAMP70.777669404
MAP3K1DDI20.775508303
MAP3K1ZCCHC90.769904404
MAP3K1IMPACT0.761243404
MAP3K1PRPF38A0.758574303
MAP3K1C6orf620.7569403
MAP3K1CAPNS20.755839505
MAP3K1AASDHPPT0.75288303
MAP3K1LEPROT0.746505303
MAP3K1CCNDBP10.746143606
MAP3K1RALGPS20.737206707
MAP3K1PGM20.735477707
MAP3K1SMIM140.734315505
MAP3K1DPH30.731751303
MAP3K1ZNF6540.728974706
MAP3K1GBP60.726901404
MAP3K1BTBD110.7269606
MAP3K1FUT110.721571303

For details and further investigation, click here