A PHP Error was encountered

Severity: Warning

Message: exec(): Unable to fork [Rscript361 /data/webapp/var/www/html/ESCCdb/application/scripts/R/getGeneSurvival_Xena.R SMIM14 /data/webapp/var/www/html/ESCCdb/application/scripts/R/Xena_EXP_survival.RData application/survivalPlots/Xena]

Filename: controllers/Result_pages.php

Line Number: 123

Backtrace:

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 123
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 387
Function: drawSurvPlot

File: /data/webapp/var/www/html/ESCCdb/index.php
Line: 315
Function: require_once

Multi-Omics Database of ESCC

 

SMIM14

 

Full name: small integral membrane protein 14 Alias Symbol: FLJ13289
Type: protein-coding gene Cytoband: 4p14
Entrez ID: 201895 HGNC ID: HGNC:27321 Ensembl Gene: ENSG00000163683 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of SMIM14:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMIM14 201895 227052_at -0.4044 0.4858
GSE20347 SMIM14 201895 222336_at -0.0209 0.8780
GSE23400 SMIM14 201895 222336_at -0.0760 0.0081
GSE26886 SMIM14 201895 227052_at -1.2910 0.0000
GSE29001 SMIM14 201895 222336_at -0.1172 0.8164
GSE38129 SMIM14 201895 222336_at -0.2068 0.1060
GSE45670 SMIM14 201895 227052_at -0.8797 0.0004
GSE53622 SMIM14 201895 71471 -1.1083 0.0000
GSE53624 SMIM14 201895 71471 -1.2195 0.0000
GSE63941 SMIM14 201895 227052_at -1.9650 0.0137
GSE77861 SMIM14 201895 227052_at -1.2503 0.0020
SRP007169 SMIM14 201895 RNAseq -1.8372 0.0000
SRP008496 SMIM14 201895 RNAseq -1.2122 0.0000
SRP064894 SMIM14 201895 RNAseq -0.6887 0.0003
SRP133303 SMIM14 201895 RNAseq -0.8879 0.0000
SRP159526 SMIM14 201895 RNAseq -1.1775 0.0001
SRP193095 SMIM14 201895 RNAseq -1.2728 0.0000
SRP219564 SMIM14 201895 RNAseq -0.5194 0.2206

Upregulated datasets: 0; Downregulated datasets: 9.  

 

Survival by SMIM14 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of SMIM14:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMIM14 201895 0 16 14
GSE20123 SMIM14 201895 0 16 14
GSE43470 SMIM14 201895 0 15 28
GSE46452 SMIM14 201895 1 36 22
GSE47630 SMIM14 201895 1 19 20
GSE54993 SMIM14 201895 8 0 62
GSE54994 SMIM14 201895 3 10 40
GSE60625 SMIM14 201895 0 0 11
GSE74703 SMIM14 201895 0 12 24
GSE74704 SMIM14 201895 0 9 11
TCGA SMIM14 201895 10 45 41

Total number of gains: 23; Total number of losses: 178; Total Number of normals: 287.  

 

Somatic mutations of SMIM14:

 

Generating mutation plots.

 

Highly correlated genes for SMIM14:

 

Showing top 20/1214 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMIM14MPC10.822077505
SMIM14GPD1L0.817627505
SMIM14SASH10.812619606
SMIM14SNORA680.802064303
SMIM14GALNT120.798224505
SMIM14GBP60.795573303
SMIM14HSD17B40.79246606
SMIM14SH3BGRL20.775904505
SMIM14TMEM9B0.774564606
SMIM14ABLIM10.769685505
SMIM14EEA10.768538505
SMIM14CYP4B10.767965505
SMIM14PIK3C2G0.765552606
SMIM14ST6GALNAC10.763702505
SMIM14DMXL10.75978606
SMIM14TMEM590.759748606
SMIM14CHP10.759625505
SMIM14LMBRD10.75637606
SMIM14ALDH9A10.754924706
SMIM14MGST20.754501505

For details and further investigation, click here