| Full name: DNA damage inducible 1 homolog 2 | Alias Symbol: MGC14844 | ||
| Type: protein-coding gene | Cytoband: 1p36.21 | ||
| Entrez ID: 84301 | HGNC ID: HGNC:24578 | Ensembl Gene: ENSG00000197312 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DDI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | DDI2 | 84301 | 98654 | -0.4954 | 0.0000 | |
| GSE53624 | DDI2 | 84301 | 8287 | -0.5283 | 0.0000 | |
| GSE97050 | DDI2 | 84301 | A_33_P3284408 | -0.3000 | 0.3201 | |
| SRP007169 | DDI2 | 84301 | RNAseq | -0.9389 | 0.0177 | |
| SRP008496 | DDI2 | 84301 | RNAseq | -0.6994 | 0.0036 | |
| SRP064894 | DDI2 | 84301 | RNAseq | -0.7734 | 0.0002 | |
| SRP133303 | DDI2 | 84301 | RNAseq | -0.5509 | 0.0000 | |
| SRP159526 | DDI2 | 84301 | RNAseq | -1.0470 | 0.0001 | |
| SRP193095 | DDI2 | 84301 | RNAseq | -0.7500 | 0.0000 | |
| SRP219564 | DDI2 | 84301 | RNAseq | -1.0696 | 0.0536 | |
| TCGA | DDI2 | 84301 | RNAseq | 0.0744 | 0.4002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DDI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDI2 | 84301 | 1 | 5 | 24 | |
| GSE20123 | DDI2 | 84301 | 1 | 4 | 25 | |
| GSE43470 | DDI2 | 84301 | 1 | 8 | 34 | |
| GSE46452 | DDI2 | 84301 | 7 | 1 | 51 | |
| GSE47630 | DDI2 | 84301 | 8 | 3 | 29 | |
| GSE54993 | DDI2 | 84301 | 3 | 1 | 66 | |
| GSE54994 | DDI2 | 84301 | 10 | 4 | 39 | |
| GSE60625 | DDI2 | 84301 | 0 | 0 | 11 | |
| GSE74703 | DDI2 | 84301 | 1 | 5 | 30 | |
| GSE74704 | DDI2 | 84301 | 1 | 0 | 19 | |
| TCGA | DDI2 | 84301 | 12 | 23 | 61 |
Total number of gains: 45; Total number of losses: 54; Total Number of normals: 389.
Somatic mutations of DDI2:
Generating mutation plots.
Highly correlated genes for DDI2:
Showing top 20/293 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDI2 | TOM1 | 0.817109 | 3 | 0 | 3 |
| DDI2 | MTF1 | 0.813471 | 3 | 0 | 3 |
| DDI2 | ULK3 | 0.799338 | 3 | 0 | 3 |
| DDI2 | COMTD1 | 0.79567 | 3 | 0 | 3 |
| DDI2 | PLEKHM1 | 0.794617 | 3 | 0 | 3 |
| DDI2 | RABGGTA | 0.793538 | 3 | 0 | 3 |
| DDI2 | STRN | 0.791698 | 3 | 0 | 3 |
| DDI2 | PLD2 | 0.787172 | 3 | 0 | 3 |
| DDI2 | CERS4 | 0.782546 | 3 | 0 | 3 |
| DDI2 | MARK2 | 0.778111 | 3 | 0 | 3 |
| DDI2 | TIAM1 | 0.777779 | 3 | 0 | 3 |
| DDI2 | NLRX1 | 0.776142 | 3 | 0 | 3 |
| DDI2 | MAP3K1 | 0.775508 | 3 | 0 | 3 |
| DDI2 | FBXO42 | 0.773189 | 3 | 0 | 3 |
| DDI2 | RGS14 | 0.773152 | 3 | 0 | 3 |
| DDI2 | RAB3D | 0.772448 | 3 | 0 | 3 |
| DDI2 | SLC16A6 | 0.767497 | 3 | 0 | 3 |
| DDI2 | VPS37B | 0.766216 | 3 | 0 | 3 |
| DDI2 | ASCC2 | 0.766158 | 3 | 0 | 3 |
| DDI2 | PRKCH | 0.764029 | 3 | 0 | 3 |
For details and further investigation, click here
