| Full name: diphthamide biosynthesis 3 | Alias Symbol: DESR1|DELGIP1|MGC20197|KTI11|DELGIP|DPH3A | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 285381 | HGNC ID: HGNC:27717 | Ensembl Gene: ENSG00000154813 | OMIM ID: 608959 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DPH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPH3 | 285381 | 225200_at | -0.5407 | 0.3093 | |
| GSE26886 | DPH3 | 285381 | 225200_at | -0.4931 | 0.1325 | |
| GSE45670 | DPH3 | 285381 | 225195_at | 0.2650 | 0.1856 | |
| GSE53622 | DPH3 | 285381 | 100441 | -0.2871 | 0.0001 | |
| GSE53624 | DPH3 | 285381 | 100441 | -0.2698 | 0.0010 | |
| GSE63941 | DPH3 | 285381 | 225195_at | -0.1858 | 0.7073 | |
| GSE77861 | DPH3 | 285381 | 225195_at | -0.9147 | 0.0405 | |
| GSE97050 | DPH3 | 285381 | A_23_P69188 | -0.2319 | 0.3138 | |
| SRP007169 | DPH3 | 285381 | RNAseq | -0.4120 | 0.2275 | |
| SRP008496 | DPH3 | 285381 | RNAseq | 0.0275 | 0.9059 | |
| SRP064894 | DPH3 | 285381 | RNAseq | -0.1699 | 0.3148 | |
| SRP133303 | DPH3 | 285381 | RNAseq | 0.1597 | 0.2121 | |
| SRP159526 | DPH3 | 285381 | RNAseq | -0.3951 | 0.1248 | |
| SRP193095 | DPH3 | 285381 | RNAseq | -0.3779 | 0.0012 | |
| SRP219564 | DPH3 | 285381 | RNAseq | -0.4237 | 0.2348 | |
| TCGA | DPH3 | 285381 | RNAseq | -0.3129 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DPH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPH3 | 285381 | 2 | 18 | 10 | |
| GSE20123 | DPH3 | 285381 | 2 | 18 | 10 | |
| GSE43470 | DPH3 | 285381 | 0 | 20 | 23 | |
| GSE46452 | DPH3 | 285381 | 2 | 17 | 40 | |
| GSE47630 | DPH3 | 285381 | 2 | 23 | 15 | |
| GSE54993 | DPH3 | 285381 | 6 | 1 | 63 | |
| GSE54994 | DPH3 | 285381 | 1 | 32 | 20 | |
| GSE60625 | DPH3 | 285381 | 5 | 0 | 6 | |
| GSE74703 | DPH3 | 285381 | 0 | 17 | 19 | |
| GSE74704 | DPH3 | 285381 | 1 | 12 | 7 | |
| TCGA | DPH3 | 285381 | 1 | 68 | 27 |
Total number of gains: 22; Total number of losses: 226; Total Number of normals: 240.
Somatic mutations of DPH3:
Generating mutation plots.
Highly correlated genes for DPH3:
Showing top 20/512 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPH3 | PHYHIPL | 0.786869 | 3 | 0 | 3 |
| DPH3 | CETN3 | 0.775773 | 3 | 0 | 3 |
| DPH3 | RSL24D1 | 0.77403 | 3 | 0 | 3 |
| DPH3 | LATS2 | 0.767942 | 3 | 0 | 3 |
| DPH3 | MTX3 | 0.766293 | 3 | 0 | 3 |
| DPH3 | NTAN1 | 0.761703 | 3 | 0 | 3 |
| DPH3 | PITPNM2 | 0.755147 | 3 | 0 | 3 |
| DPH3 | TMOD2 | 0.752768 | 3 | 0 | 3 |
| DPH3 | UFL1 | 0.749731 | 3 | 0 | 3 |
| DPH3 | DNAJB5 | 0.74666 | 3 | 0 | 3 |
| DPH3 | MTMR6 | 0.741153 | 4 | 0 | 3 |
| DPH3 | ZNF649 | 0.736668 | 3 | 0 | 3 |
| DPH3 | CMC1 | 0.734801 | 3 | 0 | 3 |
| DPH3 | PPP1R2 | 0.734774 | 4 | 0 | 4 |
| DPH3 | METTL9 | 0.733798 | 3 | 0 | 3 |
| DPH3 | MAP3K1 | 0.731751 | 3 | 0 | 3 |
| DPH3 | UGP2 | 0.728033 | 5 | 0 | 4 |
| DPH3 | LSM11 | 0.727766 | 5 | 0 | 4 |
| DPH3 | COX7A1 | 0.726723 | 3 | 0 | 3 |
| DPH3 | GNG11 | 0.725958 | 3 | 0 | 3 |
For details and further investigation, click here
