| Full name: Ral GEF with PH domain and SH3 binding motif 2 | Alias Symbol: KIAA0351|FLJ10244|FLJ25604 | ||
| Type: protein-coding gene | Cytoband: 1q25.2 | ||
| Entrez ID: 55103 | HGNC ID: HGNC:30279 | Ensembl Gene: ENSG00000116191 | OMIM ID: 617819 |
| Drug and gene relationship at DGIdb | |||
Expression of RALGPS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RALGPS2 | 55103 | 227224_at | -0.3492 | 0.6051 | |
| GSE20347 | RALGPS2 | 55103 | 220338_at | -0.2478 | 0.2989 | |
| GSE23400 | RALGPS2 | 55103 | 220338_at | -0.1578 | 0.0001 | |
| GSE26886 | RALGPS2 | 55103 | 227224_at | -1.7647 | 0.0000 | |
| GSE29001 | RALGPS2 | 55103 | 220338_at | -0.6804 | 0.1596 | |
| GSE38129 | RALGPS2 | 55103 | 220338_at | -0.3104 | 0.2688 | |
| GSE45670 | RALGPS2 | 55103 | 227224_at | -0.4705 | 0.0315 | |
| GSE53622 | RALGPS2 | 55103 | 23233 | -1.3165 | 0.0000 | |
| GSE53624 | RALGPS2 | 55103 | 23233 | -1.5201 | 0.0000 | |
| GSE63941 | RALGPS2 | 55103 | 227224_at | -1.5923 | 0.0296 | |
| GSE77861 | RALGPS2 | 55103 | 227224_at | -0.9456 | 0.0047 | |
| GSE97050 | RALGPS2 | 55103 | A_24_P173746 | -0.1881 | 0.7289 | |
| SRP007169 | RALGPS2 | 55103 | RNAseq | -1.5839 | 0.0001 | |
| SRP008496 | RALGPS2 | 55103 | RNAseq | -1.2242 | 0.0000 | |
| SRP064894 | RALGPS2 | 55103 | RNAseq | -1.6764 | 0.0000 | |
| SRP133303 | RALGPS2 | 55103 | RNAseq | -0.9185 | 0.0000 | |
| SRP159526 | RALGPS2 | 55103 | RNAseq | -1.1553 | 0.0148 | |
| SRP193095 | RALGPS2 | 55103 | RNAseq | -1.0928 | 0.0000 | |
| SRP219564 | RALGPS2 | 55103 | RNAseq | -1.5474 | 0.0049 | |
| TCGA | RALGPS2 | 55103 | RNAseq | -0.0499 | 0.6052 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by RALGPS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RALGPS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RALGPS2 | 55103 | 12 | 0 | 18 | |
| GSE20123 | RALGPS2 | 55103 | 12 | 0 | 18 | |
| GSE43470 | RALGPS2 | 55103 | 9 | 1 | 33 | |
| GSE46452 | RALGPS2 | 55103 | 3 | 1 | 55 | |
| GSE47630 | RALGPS2 | 55103 | 14 | 0 | 26 | |
| GSE54993 | RALGPS2 | 55103 | 0 | 6 | 64 | |
| GSE54994 | RALGPS2 | 55103 | 15 | 0 | 38 | |
| GSE60625 | RALGPS2 | 55103 | 0 | 0 | 11 | |
| GSE74703 | RALGPS2 | 55103 | 8 | 1 | 27 | |
| GSE74704 | RALGPS2 | 55103 | 5 | 0 | 15 | |
| TCGA | RALGPS2 | 55103 | 40 | 4 | 52 |
Total number of gains: 118; Total number of losses: 13; Total Number of normals: 357.
Somatic mutations of RALGPS2:
Generating mutation plots.
Highly correlated genes for RALGPS2:
Showing top 20/1501 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RALGPS2 | RASSF5 | 0.822484 | 7 | 0 | 7 |
| RALGPS2 | CAPN14 | 0.804092 | 6 | 0 | 6 |
| RALGPS2 | C6orf132 | 0.796108 | 6 | 0 | 6 |
| RALGPS2 | ARHGAP27 | 0.795095 | 7 | 0 | 7 |
| RALGPS2 | CA13 | 0.789714 | 3 | 0 | 3 |
| RALGPS2 | PSMC6 | 0.779344 | 3 | 0 | 3 |
| RALGPS2 | TMEM51 | 0.778815 | 3 | 0 | 3 |
| RALGPS2 | FRMD6 | 0.778396 | 3 | 0 | 3 |
| RALGPS2 | ZNF92 | 0.778051 | 3 | 0 | 3 |
| RALGPS2 | C15orf48 | 0.777018 | 6 | 0 | 6 |
| RALGPS2 | PLEKHF2 | 0.774537 | 3 | 0 | 3 |
| RALGPS2 | GRPEL2 | 0.774117 | 7 | 0 | 7 |
| RALGPS2 | ZNF823 | 0.772127 | 7 | 0 | 7 |
| RALGPS2 | ZDHHC21 | 0.76843 | 7 | 0 | 7 |
| RALGPS2 | GRHL3 | 0.763661 | 6 | 0 | 6 |
| RALGPS2 | ZW10 | 0.759466 | 3 | 0 | 3 |
| RALGPS2 | VSIG10L | 0.756503 | 6 | 0 | 6 |
| RALGPS2 | SLC46A2 | 0.751789 | 7 | 0 | 7 |
| RALGPS2 | PLEKHA7 | 0.750648 | 7 | 0 | 7 |
| RALGPS2 | RNF141 | 0.750355 | 8 | 0 | 7 |
For details and further investigation, click here
