Full name: mitogen-activated protein kinase kinase kinase 7	Alias Symbol: MEKK7
Type: protein-coding gene	Cytoband: 6q15
Entrez ID: 6885	HGNC ID: HGNC:6859	Ensembl Gene: ENSG00000135341	OMIM ID: 602614
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 52/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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MAP3K7 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04064	NF-kappa B signaling pathway	View
hsa04152	AMPK signaling pathway	View
hsa04310	Wnt signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04520	Adherens junction	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04621	NOD-like receptor signaling pathway	View
hsa04622	RIG-I-like receptor signaling pathway	View
hsa04660	T cell receptor signaling pathway	View
hsa04668	TNF signaling pathway	View
hsa05140	Leishmaniasis	View
hsa05145	Toxoplasmosis	View
hsa05162	Measles	View
hsa05168	Herpes simplex infection	View
hsa05169	Epstein-Barr virus infection	View

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Expression of MAP3K7:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	MAP3K7	6885	206854_s_at	0.2851	0.3393	Show
GSE20347	MAP3K7	6885	206854_s_at	0.5282	0.0002	Show
GSE23400	MAP3K7	6885	206853_s_at	0.1209	0.0051	Show
GSE26886	MAP3K7	6885	206854_s_at	0.3932	0.1048	Show
GSE29001	MAP3K7	6885	206854_s_at	0.4117	0.2225	Show
GSE38129	MAP3K7	6885	206854_s_at	0.5487	0.0050	Show
GSE45670	MAP3K7	6885	206854_s_at	0.4235	0.0001	Show
GSE53622	MAP3K7	6885	63343	0.4647	0.0000	Show
GSE53624	MAP3K7	6885	63343	0.3641	0.0000	Show
GSE63941	MAP3K7	6885	211537_x_at	0.9147	0.0181	Show
GSE77861	MAP3K7	6885	211536_x_at	0.3471	0.2513	Show
GSE97050	MAP3K7	6885	A_23_P500773	0.3387	0.1734	Show
SRP007169	MAP3K7	6885	RNAseq	0.8747	0.0151	Show
SRP008496	MAP3K7	6885	RNAseq	0.9097	0.0000	Show
SRP064894	MAP3K7	6885	RNAseq	0.2148	0.2138	Show
SRP133303	MAP3K7	6885	RNAseq	0.3787	0.0208	Show
SRP159526	MAP3K7	6885	RNAseq	0.1455	0.3719	Show
SRP193095	MAP3K7	6885	RNAseq	0.0887	0.1967	Show
SRP219564	MAP3K7	6885	RNAseq	-0.0713	0.7911	Show
TCGA	MAP3K7	6885	RNAseq	0.0878	0.0916	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by MAP3K7 expression:

 

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Copy number change of MAP3K7:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	MAP3K7	6885	1	4	25	Show
GSE20123	MAP3K7	6885	1	3	26	Show
GSE43470	MAP3K7	6885	2	1	40	Show
GSE46452	MAP3K7	6885	2	11	46	Show
GSE47630	MAP3K7	6885	8	6	26	Show
GSE54993	MAP3K7	6885	3	2	65	Show
GSE54994	MAP3K7	6885	8	8	37	Show
GSE60625	MAP3K7	6885	0	1	10	Show
GSE74703	MAP3K7	6885	2	1	33	Show
GSE74704	MAP3K7	6885	0	2	18	Show
TCGA	MAP3K7	6885	6	22	68	Show

Total number of gains: 33; Total number of losses: 61; Total Number of normals: 394.  Download Data

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Somatic mutations of MAP3K7:

 

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Highly correlated genes for MAP3K7:

 

Showing top 20/1336 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
MAP3K7	ESCO1	0.790066	3	0	3
MAP3K7	WDR54	0.767763	3	0	3
MAP3K7	ANAPC4	0.765726	3	0	3
MAP3K7	RNF149	0.749656	3	0	3
MAP3K7	MMS22L	0.735203	3	0	3
MAP3K7	TMEM167A	0.73422	3	0	3
MAP3K7	PET117	0.732666	3	0	3
MAP3K7	SLC7A6OS	0.728456	3	0	3
MAP3K7	THADA	0.723579	3	0	3
MAP3K7	DGKH	0.72143	4	0	3
MAP3K7	HARS2	0.719185	3	0	3
MAP3K7	RNF166	0.717822	3	0	3
MAP3K7	TMTC3	0.715664	4	0	4
MAP3K7	DUSP23	0.709094	3	0	3
MAP3K7	SLC25A40	0.70823	3	0	3
MAP3K7	MARK3	0.70759	3	0	3
MAP3K7	MRPL52	0.706217	4	0	3
MAP3K7	FTSJ1	0.705582	3	0	3
MAP3K7	KIF16B	0.705319	4	0	4
MAP3K7	EPRS	0.705137	4	0	3

For details and further investigation, click here