| Full name: histidyl-tRNA synthetase 2, mitochondrial | Alias Symbol: HO3|HARSR | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 23438 | HGNC ID: HGNC:4817 | Ensembl Gene: ENSG00000112855 | OMIM ID: 600783 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HARS2 | 23438 | 209252_at | 0.1340 | 0.8034 | |
| GSE20347 | HARS2 | 23438 | 209252_at | 0.2805 | 0.0258 | |
| GSE23400 | HARS2 | 23438 | 209252_at | 0.3201 | 0.0000 | |
| GSE26886 | HARS2 | 23438 | 209252_at | -0.4180 | 0.0775 | |
| GSE29001 | HARS2 | 23438 | 209252_at | 0.1255 | 0.5454 | |
| GSE38129 | HARS2 | 23438 | 209252_at | 0.2778 | 0.0032 | |
| GSE45670 | HARS2 | 23438 | 209252_at | 0.2320 | 0.0503 | |
| GSE53622 | HARS2 | 23438 | 168611 | -0.0614 | 0.4687 | |
| GSE53624 | HARS2 | 23438 | 168611 | -0.0544 | 0.3911 | |
| GSE63941 | HARS2 | 23438 | 209252_at | -0.1245 | 0.6958 | |
| GSE77861 | HARS2 | 23438 | 209252_at | 0.1063 | 0.6540 | |
| GSE97050 | HARS2 | 23438 | A_23_P41588 | -0.0867 | 0.7513 | |
| SRP007169 | HARS2 | 23438 | RNAseq | -0.4315 | 0.3582 | |
| SRP008496 | HARS2 | 23438 | RNAseq | -0.5013 | 0.0784 | |
| SRP064894 | HARS2 | 23438 | RNAseq | 0.1139 | 0.3752 | |
| SRP133303 | HARS2 | 23438 | RNAseq | 0.4656 | 0.0495 | |
| SRP159526 | HARS2 | 23438 | RNAseq | -0.3276 | 0.1562 | |
| SRP193095 | HARS2 | 23438 | RNAseq | -0.2854 | 0.0009 | |
| SRP219564 | HARS2 | 23438 | RNAseq | 0.1768 | 0.6338 | |
| TCGA | HARS2 | 23438 | RNAseq | -0.0775 | 0.1486 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HARS2 | 23438 | 3 | 11 | 16 | |
| GSE20123 | HARS2 | 23438 | 4 | 11 | 15 | |
| GSE43470 | HARS2 | 23438 | 2 | 10 | 31 | |
| GSE46452 | HARS2 | 23438 | 0 | 27 | 32 | |
| GSE47630 | HARS2 | 23438 | 0 | 20 | 20 | |
| GSE54993 | HARS2 | 23438 | 9 | 1 | 60 | |
| GSE54994 | HARS2 | 23438 | 2 | 14 | 37 | |
| GSE60625 | HARS2 | 23438 | 0 | 0 | 11 | |
| GSE74703 | HARS2 | 23438 | 2 | 7 | 27 | |
| GSE74704 | HARS2 | 23438 | 3 | 5 | 12 | |
| TCGA | HARS2 | 23438 | 4 | 37 | 55 |
Total number of gains: 29; Total number of losses: 143; Total Number of normals: 316.
Somatic mutations of HARS2:
Generating mutation plots.
Highly correlated genes for HARS2:
Showing top 20/217 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HARS2 | ACSL4 | 0.746054 | 3 | 0 | 3 |
| HARS2 | FNIP1 | 0.741945 | 3 | 0 | 3 |
| HARS2 | RRAGC | 0.738207 | 3 | 0 | 3 |
| HARS2 | SETD6 | 0.720163 | 3 | 0 | 3 |
| HARS2 | EBAG9 | 0.719697 | 4 | 0 | 4 |
| HARS2 | MAP3K7 | 0.719185 | 3 | 0 | 3 |
| HARS2 | DHX38 | 0.716091 | 4 | 0 | 4 |
| HARS2 | CYLD | 0.709705 | 4 | 0 | 3 |
| HARS2 | HNRNPC | 0.708685 | 3 | 0 | 3 |
| HARS2 | ESYT2 | 0.707888 | 3 | 0 | 3 |
| HARS2 | RLIM | 0.70425 | 4 | 0 | 4 |
| HARS2 | MEX3B | 0.701326 | 3 | 0 | 3 |
| HARS2 | NSMAF | 0.701191 | 3 | 0 | 3 |
| HARS2 | PIGL | 0.69282 | 3 | 0 | 3 |
| HARS2 | ISCA2 | 0.691209 | 3 | 0 | 3 |
| HARS2 | NEDD8 | 0.686775 | 4 | 0 | 3 |
| HARS2 | OXA1L | 0.685232 | 4 | 0 | 3 |
| HARS2 | RPS23 | 0.681529 | 3 | 0 | 3 |
| HARS2 | AK2 | 0.681012 | 5 | 0 | 5 |
| HARS2 | KIAA0586 | 0.679843 | 3 | 0 | 3 |
For details and further investigation, click here
