| Full name: phospholipase C delta 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 113026 | HGNC ID: HGNC:9061 | Ensembl Gene: ENSG00000161714 | OMIM ID: 608795 |
| Drug and gene relationship at DGIdb | |||
PLCD3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04919 | Thyroid hormone signaling pathway | |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
Expression of PLCD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLCD3 | 113026 | 234971_x_at | -0.1680 | 0.5800 | |
| GSE26886 | PLCD3 | 113026 | 234971_x_at | -0.0893 | 0.6191 | |
| GSE45670 | PLCD3 | 113026 | 234971_x_at | -0.0109 | 0.9116 | |
| GSE53622 | PLCD3 | 113026 | 21879 | -0.4466 | 0.0020 | |
| GSE53624 | PLCD3 | 113026 | 21879 | -0.3509 | 0.0014 | |
| GSE63941 | PLCD3 | 113026 | 234971_x_at | -0.0571 | 0.8788 | |
| GSE77861 | PLCD3 | 113026 | 234971_x_at | -0.1089 | 0.4328 | |
| GSE97050 | PLCD3 | 113026 | A_23_P351757 | -0.2964 | 0.1862 | |
| SRP007169 | PLCD3 | 113026 | RNAseq | -0.8989 | 0.1594 | |
| SRP064894 | PLCD3 | 113026 | RNAseq | -0.6928 | 0.0001 | |
| SRP133303 | PLCD3 | 113026 | RNAseq | -0.3355 | 0.1289 | |
| SRP159526 | PLCD3 | 113026 | RNAseq | -0.8055 | 0.0152 | |
| SRP193095 | PLCD3 | 113026 | RNAseq | -0.5604 | 0.0175 | |
| SRP219564 | PLCD3 | 113026 | RNAseq | -0.8179 | 0.0024 | |
| TCGA | PLCD3 | 113026 | RNAseq | -0.3014 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PLCD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLCD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLCD3 | 113026 | 6 | 2 | 22 | |
| GSE20123 | PLCD3 | 113026 | 6 | 2 | 22 | |
| GSE43470 | PLCD3 | 113026 | 1 | 2 | 40 | |
| GSE46452 | PLCD3 | 113026 | 32 | 0 | 27 | |
| GSE47630 | PLCD3 | 113026 | 9 | 0 | 31 | |
| GSE54993 | PLCD3 | 113026 | 3 | 4 | 63 | |
| GSE54994 | PLCD3 | 113026 | 9 | 5 | 39 | |
| GSE60625 | PLCD3 | 113026 | 4 | 0 | 7 | |
| GSE74703 | PLCD3 | 113026 | 1 | 1 | 34 | |
| GSE74704 | PLCD3 | 113026 | 4 | 1 | 15 | |
| TCGA | PLCD3 | 113026 | 27 | 6 | 63 |
Total number of gains: 102; Total number of losses: 23; Total Number of normals: 363.
Somatic mutations of PLCD3:
Generating mutation plots.
Highly correlated genes for PLCD3:
Showing top 20/117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLCD3 | BEGAIN | 0.770615 | 3 | 0 | 3 |
| PLCD3 | ZFYVE9 | 0.757188 | 3 | 0 | 3 |
| PLCD3 | E2F4 | 0.752994 | 4 | 0 | 4 |
| PLCD3 | ZNHIT6 | 0.751663 | 3 | 0 | 3 |
| PLCD3 | RNLS | 0.747707 | 3 | 0 | 3 |
| PLCD3 | POLR2L | 0.746647 | 3 | 0 | 3 |
| PLCD3 | GPHN | 0.742254 | 4 | 0 | 3 |
| PLCD3 | RNF214 | 0.739451 | 3 | 0 | 3 |
| PLCD3 | MIPEP | 0.73414 | 3 | 0 | 3 |
| PLCD3 | AAAS | 0.729791 | 3 | 0 | 3 |
| PLCD3 | MAPK12 | 0.729057 | 3 | 0 | 3 |
| PLCD3 | ALDH1A3 | 0.723382 | 3 | 0 | 3 |
| PLCD3 | AIFM1 | 0.717014 | 3 | 0 | 3 |
| PLCD3 | SLC29A3 | 0.713522 | 3 | 0 | 3 |
| PLCD3 | UNC45A | 0.711247 | 3 | 0 | 3 |
| PLCD3 | SCAF1 | 0.707721 | 3 | 0 | 3 |
| PLCD3 | MYO1D | 0.700395 | 3 | 0 | 3 |
| PLCD3 | IQGAP1 | 0.694481 | 4 | 0 | 3 |
| PLCD3 | ZNF287 | 0.692821 | 3 | 0 | 3 |
| PLCD3 | SBF2 | 0.691821 | 4 | 0 | 3 |
For details and further investigation, click here
