| Full name: arginine vasopressin receptor 1A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q14.2 | ||
| Entrez ID: 552 | HGNC ID: HGNC:895 | Ensembl Gene: ENSG00000166148 | OMIM ID: 600821 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
AVPR1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction |
Expression of AVPR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AVPR1A | 552 | 242680_at | -0.5706 | 0.5204 | |
| GSE20347 | AVPR1A | 552 | 206252_s_at | -0.0343 | 0.6622 | |
| GSE23400 | AVPR1A | 552 | 206250_x_at | -0.1118 | 0.0002 | |
| GSE26886 | AVPR1A | 552 | 206250_x_at | 0.0301 | 0.8720 | |
| GSE29001 | AVPR1A | 552 | 206250_x_at | 0.0439 | 0.7830 | |
| GSE38129 | AVPR1A | 552 | 206250_x_at | -0.1053 | 0.0757 | |
| GSE45670 | AVPR1A | 552 | 242680_at | -0.6159 | 0.1664 | |
| GSE53622 | AVPR1A | 552 | 73975 | -0.3254 | 0.0992 | |
| GSE53624 | AVPR1A | 552 | 73975 | -0.4983 | 0.0168 | |
| GSE63941 | AVPR1A | 552 | 206250_x_at | 0.1341 | 0.5418 | |
| GSE77861 | AVPR1A | 552 | 206250_x_at | -0.1711 | 0.3105 | |
| GSE97050 | AVPR1A | 552 | A_23_P25246 | 0.2020 | 0.6427 | |
| SRP007169 | AVPR1A | 552 | RNAseq | 2.4166 | 0.0108 | |
| SRP133303 | AVPR1A | 552 | RNAseq | -0.0806 | 0.7665 | |
| SRP159526 | AVPR1A | 552 | RNAseq | -1.0156 | 0.1537 | |
| SRP193095 | AVPR1A | 552 | RNAseq | 1.6265 | 0.0000 | |
| SRP219564 | AVPR1A | 552 | RNAseq | -0.5588 | 0.4389 | |
| TCGA | AVPR1A | 552 | RNAseq | -0.7432 | 0.0044 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AVPR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AVPR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AVPR1A | 552 | 3 | 1 | 26 | |
| GSE20123 | AVPR1A | 552 | 3 | 1 | 26 | |
| GSE43470 | AVPR1A | 552 | 4 | 0 | 39 | |
| GSE46452 | AVPR1A | 552 | 10 | 0 | 49 | |
| GSE47630 | AVPR1A | 552 | 10 | 2 | 28 | |
| GSE54993 | AVPR1A | 552 | 0 | 5 | 65 | |
| GSE54994 | AVPR1A | 552 | 6 | 1 | 46 | |
| GSE60625 | AVPR1A | 552 | 0 | 0 | 11 | |
| GSE74703 | AVPR1A | 552 | 4 | 0 | 32 | |
| GSE74704 | AVPR1A | 552 | 2 | 1 | 17 | |
| TCGA | AVPR1A | 552 | 17 | 9 | 70 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of AVPR1A:
Generating mutation plots.
Highly correlated genes for AVPR1A:
Showing top 20/421 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AVPR1A | C11orf96 | 0.768731 | 3 | 0 | 3 |
| AVPR1A | KCNJ4 | 0.748706 | 3 | 0 | 3 |
| AVPR1A | NLGN4Y | 0.736582 | 3 | 0 | 3 |
| AVPR1A | VGF | 0.733818 | 3 | 0 | 3 |
| AVPR1A | FOXP4 | 0.72166 | 3 | 0 | 3 |
| AVPR1A | IL6 | 0.707436 | 5 | 0 | 5 |
| AVPR1A | MAPK12 | 0.703992 | 3 | 0 | 3 |
| AVPR1A | ZNF208 | 0.703187 | 3 | 0 | 3 |
| AVPR1A | DUSP19 | 0.695488 | 3 | 0 | 3 |
| AVPR1A | PLIN4 | 0.694992 | 3 | 0 | 3 |
| AVPR1A | ZNF8 | 0.693924 | 3 | 0 | 3 |
| AVPR1A | DNMT3L | 0.692143 | 4 | 0 | 4 |
| AVPR1A | TNFRSF8 | 0.691323 | 5 | 0 | 5 |
| AVPR1A | TMEM176B | 0.687807 | 4 | 0 | 4 |
| AVPR1A | EVC2 | 0.686881 | 3 | 0 | 3 |
| AVPR1A | NELL1 | 0.680309 | 3 | 0 | 3 |
| AVPR1A | IRS4 | 0.679796 | 3 | 0 | 3 |
| AVPR1A | MBLAC1 | 0.67943 | 3 | 0 | 3 |
| AVPR1A | PRELID1 | 0.675752 | 3 | 0 | 3 |
| AVPR1A | PRKAG1 | 0.674929 | 3 | 0 | 3 |
For details and further investigation, click here
