| Full name: importin 11 | Alias Symbol: RanBP11 | ||
| Type: protein-coding gene | Cytoband: 5q12.1 | ||
| Entrez ID: 51194 | HGNC ID: HGNC:20628 | Ensembl Gene: ENSG00000086200 | OMIM ID: 610889 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IPO11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IPO11 | 51194 | 1557770_at | -0.0410 | 0.8716 | |
| GSE26886 | IPO11 | 51194 | 1557770_at | 0.0325 | 0.8404 | |
| GSE45670 | IPO11 | 51194 | 1557770_at | 0.2034 | 0.0090 | |
| GSE53622 | IPO11 | 51194 | 83305 | -0.1848 | 0.0046 | |
| GSE53624 | IPO11 | 51194 | 83305 | 0.0763 | 0.1396 | |
| GSE63941 | IPO11 | 51194 | 1557770_at | 0.2545 | 0.1164 | |
| GSE77861 | IPO11 | 51194 | 1557770_at | 0.0184 | 0.8653 | |
| GSE97050 | IPO11 | 51194 | A_23_P30264 | 0.1575 | 0.5694 | |
| SRP007169 | IPO11 | 51194 | RNAseq | 0.6714 | 0.0918 | |
| SRP008496 | IPO11 | 51194 | RNAseq | 0.3608 | 0.1751 | |
| SRP064894 | IPO11 | 51194 | RNAseq | -0.3194 | 0.4440 | |
| SRP133303 | IPO11 | 51194 | RNAseq | 0.0938 | 0.4397 | |
| SRP159526 | IPO11 | 51194 | RNAseq | -0.2069 | 0.6278 | |
| SRP193095 | IPO11 | 51194 | RNAseq | -0.3014 | 0.0014 | |
| SRP219564 | IPO11 | 51194 | RNAseq | -0.6549 | 0.2052 | |
| TCGA | IPO11 | 51194 | RNAseq | -0.0189 | 0.7236 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IPO11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IPO11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IPO11 | 51194 | 0 | 13 | 17 | |
| GSE20123 | IPO11 | 51194 | 0 | 13 | 17 | |
| GSE43470 | IPO11 | 51194 | 1 | 12 | 30 | |
| GSE46452 | IPO11 | 51194 | 0 | 28 | 31 | |
| GSE47630 | IPO11 | 51194 | 2 | 17 | 21 | |
| GSE54993 | IPO11 | 51194 | 8 | 1 | 61 | |
| GSE54994 | IPO11 | 51194 | 2 | 20 | 31 | |
| GSE60625 | IPO11 | 51194 | 0 | 0 | 11 | |
| GSE74703 | IPO11 | 51194 | 1 | 9 | 26 | |
| GSE74704 | IPO11 | 51194 | 0 | 6 | 14 | |
| TCGA | IPO11 | 51194 | 5 | 50 | 41 |
Total number of gains: 19; Total number of losses: 169; Total Number of normals: 300.
Somatic mutations of IPO11:
Generating mutation plots.
Highly correlated genes for IPO11:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IPO11 | SMARCC2 | 0.770772 | 3 | 0 | 3 |
| IPO11 | MRPL2 | 0.751767 | 3 | 0 | 3 |
| IPO11 | BMP3 | 0.736388 | 3 | 0 | 3 |
| IPO11 | CREB5 | 0.709078 | 3 | 0 | 3 |
| IPO11 | C5AR1 | 0.705685 | 3 | 0 | 3 |
| IPO11 | MAPK12 | 0.699902 | 3 | 0 | 3 |
| IPO11 | USP42 | 0.699882 | 3 | 0 | 3 |
| IPO11 | GATA1 | 0.699479 | 4 | 0 | 3 |
| IPO11 | PCSK2 | 0.69449 | 3 | 0 | 3 |
| IPO11 | SMG9 | 0.689505 | 3 | 0 | 3 |
| IPO11 | GABBR1 | 0.685027 | 3 | 0 | 3 |
| IPO11 | TMC7 | 0.680231 | 3 | 0 | 3 |
| IPO11 | IRF2BP1 | 0.680074 | 4 | 0 | 3 |
| IPO11 | ZNF836 | 0.67635 | 4 | 0 | 3 |
| IPO11 | ZC3HC1 | 0.675219 | 3 | 0 | 3 |
| IPO11 | BEGAIN | 0.673524 | 3 | 0 | 3 |
| IPO11 | TFDP3 | 0.672507 | 3 | 0 | 3 |
| IPO11 | FIBCD1 | 0.672333 | 3 | 0 | 3 |
| IPO11 | ENKUR | 0.669041 | 4 | 0 | 4 |
| IPO11 | RAB28 | 0.668111 | 3 | 0 | 3 |
For details and further investigation, click here
